The potential for power frequency magnetic fields to enhance neoplastic transformation has been investigated in vitro using promotion-sensitive mouse epidermal JB6 cells. In a soft agar assay, 60-Hz magnetic fields of 0.01, 0.1, 1.0, or 1.1 mT flux density did not induce anchorage-independent growth. In addition, these magnetic fields did not enhance tumor promoter-induced transformation showing no increase in the maximum number of transformed colonies and no shift in the dose-response curve. Thus, these data do not support the notion that environmental exposures to magnetic fields contribute to transformation.
Revised: January 7, 2021 |
Published: July 15, 1997
Citation
Saffer J.D., G. Chen, N.H. Colburn, N.H. Colburn, and S.J. Thurston. 1997.Power frequency magnetic fields do not contribute to transformation of JB6 cells.Carcinogenesis 18, no. 7:1365-1370.PNNL-SA-28896.