REVIEW ENTIRE DOCUMENT AT: https://pnlweb.pnl.gov/projects/bsd/ERICA%20Manuscripts%20for%20Review/KD%20Rodland%20D7E80/HMEC_transactivation_ms01_15+Figs.pdf ABSTRACT: Using a single nontransformed strain of human mammary epithelial cells, we found that the ability of multiple growth factors and cytokines to induce ERK phosphorylation was dependent on EGFR activity. These included lysophosphatidic acid (LPA), uridine triphosphate, growth hormone, vascular endothelial growth factor, insulin-like growth factor-1 (IGF-1), and tumor necrosis factoralpha. In contrast, hepatocyte growth factor could stimulate ERK phosphorylation independent of EGFR activity...
Revised: June 28, 2010 |
Published: November 14, 2008
Citation
Rodland K.D., N. Bollinger, D.L. Ippolito, L. Opresko, R.J. Coffey, R.C. Zangar, and H.S. Wiley. 2008.Multiple Mechanisms are Responsible for Transactivation of the Epidermal Growth Factor Receptor in Mammary Epithelial Cells.Journal of Biological Chemistry 283, no. 46:31477-31487.PNNL-SA-59460.doi:10.1074/jbc.M800456200