Using the electron microbeam located at Pacific Northwest National Laboratory, we have investigated the incident electron energy dependence on micronuclei formation in human diploid fibroblasts, AG01522, following non-targeted irradiations at 25 and 80 keV. Examining the dose response, we find that 25 keV electrons are more effective than 80 keV electrons at producing biological damage for a given dose. Our results demonstrating the induction of micronuclei as a function of incident electron energy offer direct support for the hypothesis that the track end is responsible for the biological damage occurring in the cell.
Revised: December 2, 2005 |
Published: November 1, 2005
Citation
Sowa M.B., L.E. Kathmann, B.A. Holben, B.D. Thrall, and G.A. Kimmel. 2005.Low-LET Microbeam Investigation of the Track-End Dependence of Electron-Induced Damage in Normal Human Diploid Fibroblasts.Radiation Research 164, no. 5:677-679.PNNL-SA-42273.