In this letter, we report the synthesis of LaF3:Tb3+-MTCP (meso-Tetra(4-carboxyphenyl) porphine) nanoparticle conjugates and investigate the energy transfer as well as singlet oxygen generation following X-ray irradiation. Our observations indicate that LaF3:Tb3+-MTCP nanoparticle conjugates are efficient photodynamic agents that can be initiated by X-rays at a reasonably low dose. The addition of folic acid to facilitate targeting to folate receptors on tumor cells has no effect on the quantum yield of singlet oxygen in the nanoparticle-MTCP conjugates. Our pilot studies indicate that water-soluble scintillation nanoparticles can be potentially used to activate photodynamic therapy as a promising deep cancer treatment.
Revised: March 7, 2008 |
Published: January 28, 2008
Citation
Liu Y., W. Chen, S. Wang, and A.G. Joly. 2008.Investigation of Water-Soluble X-ray Luminescence Nanoparticles for Photodynamic Activation.Applied Physics Letters 92, no. 4:Art. No. 043901.PNNL-SA-58245.