The National Nuclear Security Administration (NNSA) Office of Nonproliferation and International Security’s (NIS) Next Generation Safeguards Initiative (NGSI) and the nuclear industry have initiated activities to develop approaches for uniquely identifying and monitoring uranium hexafluoride (UF6) cylinders. A registry (e.g., centralized, secure database) that contains information about the cylinders, their movements, and their contents is a key element of the NNSA concept for a global UF6 cylinder identification and monitoring system. Pacific Northwest National Laboratory (PNNL) is leading the development of registry concepts and recommendations for the multi-laboratory NGSI project team. To inform this effort, PNNL has investigated the publically available information regarding UF6 cylinder movements and contents, as well as what, if any, analogous registries currently are used in nuclear and non-nuclear industries.