The advent of high throughput proteomics technology for global detection and quantitation of proteins creates new opportunities and challenges for those seeking to gain greater understanding of cellular machinery. Here, we review recent advances in high-resolution capillary liquid chromatography coupled to Fourier transform ion cyclotron resonance (FTICR) mass spectrometry along with its potential application to high throughput proteomics. These technological advances combined with quantitative stable isotope labeling methodologies provide powerful tools for expanding our understanding of biology at the system-level.
Revised: June 15, 2011 |
Published: June 1, 2004
Citation
Qian W., D.G. Camp, and R.D. Smith. 2004.High Throughput Proteomics Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.Expert Review of Proteomics 1, no. 1:87-95.PNNL-SA-41680.