A primary mechanism of radiation-induced DNA damage is by generation of free radicals. Chronically increased oxidative stress from elevated body iron may increase radiation sensitivity by decreasing cellular oxygen radical scavenging capability. Hemochromatosis heterozygotes have elevated body iron. Low-level radiation sensitization by iron may be particularly pertinent for risk of breast cancer. Since ten percent of the population appears to be heterozygous for the hemochromatosis gene, a radiosensitizing effect would have pervasive implications.
Revised: May 30, 2002 |
Published: June 15, 2000
Citation
Stevens R.G., J.E. Morris, and L.E. Anderson. 2000.Hemochromatosis heterozygotes may constitute a radiation-sensitive subpopulation.Radiation Research 153, no. 6:844-847.PNNL-SA-33953.