The chirality of ferric siderophore complexes is a determinant for their cellular recognition and transport. Corynebactin (first isolated from a Gram-positive bacterium) contains L-threonine, unlike the closely related enterobactin, which contains L-serine. Also unlike enterobactin, ferric corynebactin is preferentially L at the iron center. Experimental (circular dichroism spectra and synthesis of a corynebactin/enterobactin hybrid) and theoretical (MM3 and density functional theory calculations) results explain ferric corynebactin?s properties.
Revised: November 10, 2005 |
Published: September 14, 2002
Citation
Bluhm M.E., B.P. Hay, S.S. Kim, E.A. Dertz, and K.N. Raymond. 2002.Corynebactin and a Serine Trilactone Based Analogue-Chirality and Molecular Modeling of ferric Complexes.Inorganic Chemistry 41, no. 21:5475-5478.PNNL-SA-35924.