Previous work showed that DCA produces tumors in mice that display a diffuse immunoreactivity to a c-Jun, whereas TCA-induced tumors do not. This study examines whether biomarkers for DCA and TCA can be used to determine if TRI-induced mouse liver cancer is attributable to TCA or to other metabolites (DCA). DCA and TCA (when given in various combinations) produced a few tumors that were c-Jun+, some that were c-Jun-, but many with a mixed phenotype. Thirteen TRI-induced tumors were c-Jun+, ten were c-Jun-, and seven had a mixed phenotype. Mutations of the H-ras protooncogene were also examined in DCA, TCA and TRI-induced tumors. The mutation frequency detected in tumors induced by TCA was significantly different from that observed in TRI-induced tumors (0.44 vs. 0.21, P
Revised: July 22, 2010 |
Published: July 1, 2002
Citation
Bull R.J., G.A. Orner, L.B. Sasser, R.S. Cheng, L.C. Stillwell, A.J. Stauber, and M.K. Lingohr, et al. 2002.The Contribution of Dichloroacetate and Trichloroacetate to Liver Tumor Induction in Mice by Trichloroethylene.Toxicology and Applied Pharmacology 182, no. 1:55-65. PNWD-SA-5533. doi:10.1006/taap.2002.9427