PNNL

Abstract

Human infections caused by viral pathogens trigger a complex gamut of host responses that limit disease, resolve infection, and generate immunity, but also, may contribute to severe disease or death. Here, we present methods and multi-omics data representing global host responses generated from 45 infection experiments with human viruses of the Orthomyxoviridae, Filoviridae, Flaviviridae, and Coronaviridae families. Analogous experimental designs were implemented across human or mouse host systems, longitudinal samples were collected over defined time courses, and global multi-omics data (transcriptomics, proteomics, metabolomics, and lipidomics) were acquired by microarray, RNA sequencing, or mass spectrometry analyses. For comparison, we include transcriptomics datasets from cells treated with type I and type II human interferon. Raw multi-omics data and metadata were deposited in public databases, and we provide a central location linking the raw data with experimental metadata and ready-to-use, quality-controlled, statistically processed multi-omics datasets not available in any public database. This compendium of infection-induced host response data will be useful for those endeavouring to understand viral disease pathophysiology or network biology.