June 1, 2008
Journal Article

Bacteriophage enzymes for the prevention and treatment of bacterial infections: Stability and stabilization of the enzyme lysing Streptococcus pyogenes cells

Abstract

Recombinant, phage associated lytic enzyme Ply C capable to lyse streptococci of groups A and C was stabilized in the variety of the micelles containing compositions to improve the stability of the enzyme for further application in medicine. It was shown that, in the micellar polyelectrolyte composition M16, the enzyme retained its activity for 2 months; while in a buffer solution under the same conditions ((pH 6.3, room temperature), it completely lost its activity in 2 days

Revised: December 3, 2008 | Published: June 1, 2008

Citation

Klyachko N.L., N.F. Dmitrieva, A.S. Eshchina, O.V. Ignatenko, L.Y. Filatova, E.I. Rainina, and A.K. Kazarov, et al. 2008. Bacteriophage enzymes for the prevention and treatment of bacterial infections: Stability and stabilization of the enzyme lysing Streptococcus pyogenes cells. Russian Journal of Bioorganic Chemistry 34, no. 3:p.375-379. PNNL-SA-61890. doi:10.1134/S1068162008030217