February 15, 2024
Journal Article

Advances in genome-scale metabolic models of industrially important fungi


Many fungal species have been used in industrial production for biofuels and bioproducts. Developing strains with better performance in biomanufacturing requires systematic understanding of cellular metabolism. Genome-scale metabolic models (GEMs) offer a comprehensive view of interconnected pathways and a mathematical framework for downstream analysis. Recently, GEMs have been developed or updated in several industrially important fungi. Some of them incorporate enzyme constraints, enabling improved predictions of cell states and proteome allocation. Here we provide an overview of these newly developed GEMs and computational methods that facilitate construction of enzyme-constrained GEMs and utilize flux predictions from GEMs. Furthermore, we highlight the pivotal roles of these GEMs in iterative design-build-test- learn cycles, ultimately advancing the field of fungal biomanufacturing.

Published: February 15, 2024


Han Y., A. Tafur Rangel, K.R. Pomraning, E.J. Kerkhoven, and J. Kim. 2023. Advances in genome-scale metabolic models of industrially important fungi. Current Opinion in Biotechnology 84. PNNL-SA-188501. doi:10.1016/j.copbio.2023.103005