Chemical Engineer, Biological Sciences
Chemical Engineer, Biological Sciences


Ryan Renslow’s research focuses on the identification of novel metabolites in complex samples, the relationship between microbial community structure and function, and the emergence of higher order properties in multispecies communities. To achieve this, he uses a suite of computational and mathematical tools, as well as advanced imaging techniques. Applications of his work have intersected human health, energy production, ecology, national defense, machine vision, and biotechnology research areas.

Disciplines and Skills

  • Chemical Biology and Exposure Science


  • BS, Chemical Engineering, Washington State University
  • MS, Chemical Engineering, Washington State University
  • PhD, Chemical Engineering, Washington State University
  • Postdoc, Linus Pauling Distinguished Postdoctoral Fellow, Pacific Northwest National Laboratory

Affiliations and Professional Service

  • Research Associate Professor - The Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University



  • Colby S.M., J. Nunez, N.O. Hodas, C.D. Corley, and R.S. Renslow. 2020. "Deep learning to generate in silico chemical property libraries and candidate molecules for small molecule identification in complex samples." Analytical Chemistry 92, no. 2:1720-1729. PNNL-SA-144150. doi:10.1021/acs.analchem.9b02348
  • Bohutskyi P., R.S. McClure, E.A. Hill, W.C. Nelson, W.B. Chrisler, J. Nunez, and R.S. Renslow, et al. 2019. "Metabolic effects of vitamin B12 on physiology, stress resistance, growth rate and biomass productivity of Cyanobacterium stanieri planktonic and biofilm cultures." Algal Research 42. PNNL-SA-136164. doi:10.1016/j.algal.2019.101580
  • Colby S.M., D.G. Thomas, J. Nunez, D.J. Baxter, K.R. Glaesemann, J.M. Brown, and M.A. Pirrung, et al. 2019. "ISiCLE: A Quantum Chemistry Pipeline for Establishing in Silico Collision Cross Section Libraries." Analytical Chemistry 91, no. 7:4346-4356. PNNL-SA-138476. doi:10.1021/acs.analchem.8b04567
  • Couvillion S.P., Y. Zhu, G. Nagy, J.N. Adkins, C.K. Ansong, R.S. Renslow, and P.D. Piehowski, et al. 2019. "New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells." Analyst 144, no. 3:794-807. PNNL-SA-137430. doi:10.1039/C8AN01574K
  •  Garcellano R.C., S. Moinuddin, R.P. Young, M.E. Bowden, M. Zhou, R.S. Renslow, and Y. Yesiltepe, et al. 2019. "Isolation of Tryptanthrin and Reassessment of Evidence for its Isobaric Isostere Wrightiadione in Plants of the Wrightia Genus." Journal of Natural Products 82, no. 3:440-448. PNNL-SA-135279. doi:10.1021/acs.jnatprod.8b00567
  •  Ilhardt P.D., J. Nunez, E.H. Denis, J.J. Rosnow, E.J. Krogstad, R.S. Renslow, and J.J. Moran. 2019. "High-resolution elemental mapping of the root-rhizosphere-soil continuum using laser-induced breakdown spectroscopy (LIBS)." Soil Biology and Biochemistry 131. PNNL-SA-137289. doi:10.1016/j.soilbio.2018.12.029
  •  Nunez J., S.M. Colby, D.G. Thomas, M. Tfaily, N. Tolic, E. Ulrich, and J.R. Sobus, et al. 2019. "Evaluation of In Silico Multifeature Libraries for Providing Evidence for the Presence of Small Molecules in Synthetic Blinded Samples." Journal of Chemical Information and Modeling 59, no. 9:4052-4060. PNNL-SA-148332. doi:10.1021/acs.jcim.9b00444
  •  Wojcik R., G. Nagy, I.K. Attah, I.K. Webb, V. Garimella, K.K. Weitz, and A.L. Hollerbach, et al. 2019. "SLIM Ultrahigh Resolution Ion Mobility Spectrometry Separations of Isotopologues and Isotopomers Reveal Mobility Shifts due to Mass Distribution Changes." Analytical Chemistry 91, no. 18:11952-11962. PNNL-SA-147394. doi:10.1021/acs.analchem.9b02808


  • Colby S.M., R.S. McClure, C.C. Overall, R.S. Renslow, and J.E. McDermott. 2018. "Improving network inference algorithms using resampling methods." BMC Bioinformatics 19. PNNL-SA-134995. doi:10.1186/s12859-018-2402-0
  • Kiamco M., A. Mohamed, P.T. Reardon, C. Marean-Reardon, W.M. Aframehr, D.R. Call, and H. Beyenal, et al. 2018. "STRUCTURAL AND METABOLIC RESPONSES OF STAPHYLOCOCCUS AUREUS BIOFILMS TO HYPEROSMOTIC AND ANTIBIOTIC STRESS." Biotechnology and Bioengineering 115, no. 6:1594-1603. PNNL-SA-129573. doi:10.1002/bit.26572
  • Nobela O., R.S. Renslow, D.G. Thomas, S.M. Colby, S. Sitha, P.B. Njobeh, and L. Du Preez, et al. 2018. "Efficient discrimination of natural stereoisomers of chicoric acid, an HIV-1 integrase inhibitor." JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 189. PNNL-SA-137796. doi:10.1016/j.jphotobiol.2018.10.025
  • Nunez J., C.R. Anderton, and R.S. Renslow. 2018. "Optimizing colormaps with consideration for color vision deficiency to enable accurate interpretation of scientific data." PLoS One 13, no. 7:Artice No. e0199239. PNNL-SA-130546. doi:10.1371/journal.pone.0199239
  • Wu J., A. Sabag-Daigle, M. Borton, L. Kop, B.E. Szkoda, B. Kaiser, and S.R. Lindemann, et al. 2018. "Salmonella-mediated inflammation eliminates competitors for fructose-asparagine in the gut." Infection and Immunity 86, no. 7:e00945-17. PNNL-SA-129012. doi:10.1128/IAI.00945-17
  • Yesiltepe Y., J. Nunez, S.M. Colby, D.G. Thomas, M.I. Borkum, P.N. Reardon, and N.M. Washton, et al. 2018. "An automated framework for NMR chemical shift calculations of small organic molecules." Journal of Cheminformatics 10. PNNL-SA-137588. doi:10.1186/s13321-018-0305-8


  • Bernstein H.C., C.J. Brislawn, R.S. Renslow, K.L. Dana, B.R. Morton, S.R. Lindemann, and H. Song, et al. 2017. "Trade-offs between microbiome diversity and productivity in a stratified microbial mat." The ISME Journal 11, no. 2:405-414. PNNL-SA-120993. doi:10.1038/ismej.2016.133
  • Butler M., H.S. Mehta, Y. Chen, P.N. Reardon, R.S. Renslow, M. Khbeis, and D. Irish, et al. 2017. "Toward high-resolution NMR spectroscopy of microscopic liquid samples." Physical Chemistry Chemical Physics. PCCP 19, no. 22:14256-14261. PNNL-SA-126952. doi:10.1039/c7cp01933e
  • Ma J., C.P. Casey, X. Zheng, Y.M. Ibrahim, C.S. Wilkins, R.S. Renslow, and D.G. Thomas, et al. 2017. "PIXiE: An Algorithm for Automated Ion Mobility Arrival Time Extraction and Collision Cross Section Calculation using Global Data Association." Bioinformatics 33, no. 17:2715-2722. PNNL-SA-122828. doi:10.1093/bioinformatics/btx305
  • Metz T.O., E.M. Baker, E.L. Schymanski, R.S. Renslow, D.G. Thomas, T.J. Causon, and I.K. Webb, et al. 2017. "Integrating Ion Mobility Spectrometry into Mass Spectrometry-based Exposome Measurements: What Can It Add and How Far Can It Go?." Bioanalysis 9, no. 1:81-98. PNNL-SA-121158. doi:10.4155/bio-2016-0244
  • Mobberley J.M., S.R. Lindemann, H.C. Bernstein, J.J. Moran, R.S. Renslow, J.T. Babauta, and D. Hu, et al. 2017. "Organismal and spatial partitioning of energy and macronutrient transformations within a hypersaline mat." FEMS Microbiology Ecology 93, no. 4:Article No. fix028. PNNL-SA-124562. doi:10.1093/femsec/fix028
  • Renslow R.S., B. Ahmed, J. Nunez, B. Cao, P.D. Majors, J.K. Fredrickson, and H. Beyenal. 2017. "Modeling substrate utilization, metabolite production, and uranium immobilization in Shewanella oneidensis biofilms." Frontiers in Environmental Science 5. PNNL-SA-123748. doi:10.3389/fenvs.2017.00030
  • Renslow R.S., M.J. Marshall, A.E. Tucker, W.B. Chrisler, and X. Yu. 2017. "In situ nuclear magnetic resonance microimaging of live biofilms in a microchannel." Analyst 142, no. 13:2363-2371. PNNL-SA-109594. doi:10.1039/C7AN00078B
  • Zheng X., R.S. Renslow, M.M. Makola, I.K. Webb, L. Deng, D.G. Thomas, and N. Govind, et al. 2017. "Structural Elucidation of cis/trans Dicaffeoylquinic Acid Photoisomerization Using Ion Mobility Spectrometry-Mass Spectrometry." The Journal of Physical Chemistry Letters 8, no. 7:1381-1388. PNNL-SA-123119. doi:10.1021/acs.jpclett.6b03015
  • Zheng X., X. Zhang, N. Schocker, R.S. Renslow, D.J. Orton, J. Khamsi, and R.A. Ashmus, et al. 2017. "Enhancing Glycan Isomer Separations with Metal Ions and Positive and Negative Polarity Ion Mobility Spectrometry-Mass Spectrometry Analyses." Analytical and Bioanalytical Chemistry 409. PNNL-SA-118977. doi:10.1007/s00216-016-9866-4


  • Graham T., R.S. Renslow, N. Govind, and S.R. Saunders. 2016. "Precursor Ion-Ion Aggregation in the Brust-Schiffrin Synthesis of Alkanethiol Nanoparticles." Journal of Physical Chemistry C 120, no. 35:19837-19847. PNNL-SA-117643. doi:10.1021/acs.jpcc.6b06155
  • Renslow R.S., S.R. Lindemann, and H. Song. 2016. "A generalized spatial measure for resilience of microbial systems." Frontiers in Microbiology 7. PNNL-SA-113459. doi:10.3389/fmicb.2016.00443
  • Zhang X., M.V. Romm, X. Zheng, E.M. Zink, Y. Kim, K.E. Burnum-Johnson, and D.J. Orton, et al. 2016. "SPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in bio?uids." Clinical Mass Spectrometry 2. PNNL-SA-117436. doi:10.1016/j.clinms.2016.11.002


  • Ha P.T., R.S. Renslow, E. Atci, P.N. Reardon, S.R. Lindemann, J.K. Fredrickson, and D.R. Call, et al. 2015. "Regulation of electron transfer processes affects phototrophic mat structure and activity." Frontiers in Microbiology 6. PNNL-SA-111996. doi:10.3389/fmicb.2015.00909
  • Harrington T.D., J.T. Babauta, E.K. Davenport, R.S. Renslow, and H. Beyenal. 2015. "Excess Surface Area in Bioelectrochemical Systems Causes ion Transport Limitations." Biotechnology and Bioengineering 112, no. 5:858-866. PNNL-SA-107829. doi:10.1002/bit.25500
  • Harrington T.D., V.N. Tran, A. Mohamed, R.S. Renslow, S. Biria, L. Orfe, and D.R. Call, et al. 2015. "The mechanism of neutral red-mediated microbial electrosynthesis in Escherichia coli: menaquinone reduction." Bioresource Technology 192. PNNL-SA-110736. doi:10.1016/j.biortech.2015.06.037
  • Lone A.G., E. Atci, R.S. Renslow, H. Beyenal, S. Noh, B. Fransson, and N. Abu-Lail, et al. 2015. "Colonization of epidermal tissue by Staphylococcus aureus produces localized hypoxia and stimulates secretion of antioxidant and caspase-14 proteins." Infection and Immunity 83, no. 8:3026-3034. PNNL-SA-110388. doi:10.1128/IAI.00175-15
  • Lone A.G., E. Atci, R.S. Renslow, H. Beyenal, S. Noh, B. Fransson, and N. Abu-Lail, et al. 2015. "Staphylococcus aureus induces hypoxia and cellular damage in porcine dermal explants." Infection and Immunity 8, no. 6:2531-2541. PNNL-SA-110389. doi:10.1128/IAI.03075-14
  • Renslow R.S., J.T. Babauta, A.P. Kuprat, J. Schenk, C. Ivory, J.K. Fredrickson, and H. Beyenal. 2015. "MATHEMATICAL MODELING OF EXTRACELLULAR ELECTRON TRANSFER IN BIOFILMS." In Biofilms in Bioelectrochemical Systems: From Laboratory Practice to Data Interpretation. Hoboken, New Jersey:John Wiley & Sons, Inc. PNNL-SA-101138. doi:10.1002/9781119097426.ch9
  • Song H., R.S. Renslow, J.K. Fredrickson, and S.R. Lindemann. 2015. "Integrating ecological and engineering concepts of resilience in microbial communities." Frontiers in Microbiology 6. PNNL-SA-112189. doi:10.3389/fmicb.2015.01298


  • Cole J.K., J.R. Hutchison, R.S. Renslow, Y. Kim, W.B. Chrisler, H.E. Engelmann, and A. Dohnalkova, et al. 2014. "Phototrophic Biofilm Assembly in Microbial-Mat-Derived Unicyanobacterial Consortia: Model Systems for the Study of Autotroph-Heterotroph Interactions." Frontiers in Microbiology 5. PNNL-SA-99657. doi:10.3389/fmicb.2014.00109
  • Moran J.J., C.G. Doll, H.C. Bernstein, R.S. Renslow, A.B. Cory, J.R. Hutchison, and S.R. Lindemann, et al. 2014. "Spatially tracking 13C labeled substrate (bicarbonate) accumulation in microbial communities using laser ablation isotope ratio mass spectrometry." Environmental Microbiology Reports 6, no. 6:786-791. PNNL-SA-97766. doi:10.1111/1758-2229.12211
  • Renslow R.S., J.T. Babauta, P.D. Majors, H.S. Mehta, R. Ewing, T. Ewing, and K.T. Mueller, et al. 2014. "A biofilm microreactor system for simultaneous electrochemical and nuclear magnetic resonance techniques." Water Science and Technology 69, no. 5:966-973. PNNL-SA-94214. doi:10.2166/wst.2013.802
  • Resat H., R.S. Renslow, and H. Beyenal. 2014. "Reconstruction of biofilm images: combining local and global structural parameters." Biofouling 30, no. 9:1141-1154. PNNL-SA-107493. doi:10.1080/08927014.2014.969721


  • Lindemann S.R., J.J. Moran, J.C. Stegen, R.S. Renslow, J.R. Hutchison, J.K. Cole, and A. Dohnalkova, et al. 2013. "The Epsomitic Phototrophic Microbial Mat of Hot Lake, Washington: Community Structural Responses to Seasonal Cycling." Frontiers in Microbiology 4. PNNL-SA-96936. doi:10.3389/fmicb.2013.00323
  • Renslow R.S., J.T. Babauta, A. Dohnalkova, M.I. Boyanov, K.M. Kemner, P.D. Majors, and J.K. Fredrickson, et al. 2013. "Metabolic spatial variability in electrode-respiring Geobacter sulfurreducens biofilms." Energy & Environmental Science 6, no. 6:1827-1836. PNNL-SA-90428. doi:10.1039/c3ee40203g
  • Renslow R.S., J.T. Babauta, A.P. Kuprat, J. Schenk, C. Ivory, J.K. Fredrickson, and H. Beyenal. 2013. "Modeling biofilms with dual extracellular electron transfer mechanisms." Physical Chemistry Chemical Physics. PCCP 15, no. 44:19262-19283. PNNL-SA-94504. doi:10.1039/c3cp53759e
  • Renslow R.S., J.T. Babauta, P.D. Majors, and H. Beyenal. 2013. "Diffusion in biofilms respiring on electrodes." Energy and Environmental Science 6, no. 2:595-607. PNNL-SA-94190. doi:10.1039/C2EE23394K


  • Cao B., P.D. Majors, B. Ahmed, R.S. Renslow, C.P. Sylvia, L. Shi, and S. Kjelleberg, et al. 2012. "Biofilm Shows Spatially Stratified Metabolic Responses to Contaminant Exposure." Environmental Microbiology 14, no. 11:2901-2910. PNNL-SA-83917. doi:10.1111/j.1462-2920.2012.02850.x


  • Renslow R.S., P.D. Majors, J.S. McLean, J.K. Fredrickson, B. Ahmed, and H. Beyenal. 2010. "In Situ Effective Diffusion Coefficient Profiles in Live Biofilms Using Pulsed-Field Gradient Nuclear Magnetic Resonance." Biotechnology and Bioengineering 106, no. 6:928-937. PNNL-SA-70651.