Biomedical Scientist
Biomedical Scientist


Becky Hess has been a scientist at Pacific Northwest National Laboratory since 2009. She received her PhD in engineering science from Washington State University in 2013. Since earning her PhD, she has worked as a biomedical scientist focusing on host-pathogen interactions, cellular biochemistry, molecular biology, and synthetic biology. 

Research Interest

  • Biology
  • Host-Pathogen Interactions
  • Molecular Biology
  • Cellular Biochemistry
  • Synthetic Biology


  • PhD in engineering science, Washington State University


Hess, B. M., T. J. Weber. Organotypic lung model with functional immune cells. US Patent US20180119091.

Victry, K. D., R. M. Ozanich, B. M. Hess, J. R. Hutchison. Gene-matched enrichment and polymerase chain reaction for rapid detection of microorganisms. US Patent 11,104,966.

Ozanich, R. M., J. R. Hutchison, K. D. Victry, B. M. Hess. Spent enrichment media for growth of gene-matched microorganisms. US Patent 16/131,524.


Alfaro T., Elmore J. R., Stromberg Z. R., Hutchison J. R., Hess B. M. 2022. “Engineering Citrobacter freundii using CRISPR/Cas9 system.” Journal of Microbiological Methods 200: 106533.

Hess B. M., Amidan B. G., Anderson K. K., Hutchison J. R. 2016 “Evaluating composite sampling methods of Bacillus spores at low concentrations.” PLoS One 11: e0164582.

Hess B. M., Thomas D. G., Weber T. J., Hutchison J. R., Straub T. M., Bruckner-Lea C. J., Powell J. D., Kabilan S., Corley R. A. 2019. “An integrated experimental-computational approach for predicting virulence in New Zealand white rabbits and humans following inhalation exposure to Bacillus anthracis spores.” PLoS One 14: e0219160.

Hess B. M., Xue J., Markillie L. M., Taylor R. C., Wiley H. S., Ahring B. K., Linggi B. 2013. “Coregulation of terpenoid pathway genes and prediction of isoprene production in Bacillus subtilis using transcriptomics.” PLoS One 8: e66104.

Hutchison J., Piepel G., Amidan B., Hess B., Sydor M., Deatherage Kaiser B. 2018. “Comparison of false‐negative rates and limits of detection following macrofoam‐swab sampling of Bacillus anthracis surrogates via Rapid Viability PCR and plate culture.” Journal of Applied Microbiology 124: 1092-1106.

Hess M. B., Kaiser B. L. D. 2015. “Discerning Viable from Nonviable Yersinia Pestis Pgm-and Bacillus Anthracis Sterne Using Propidium Monoazide in the Presence of White Powders.” Journal of Bioterrorism & Biodefense 6.

Powell J. D., Hess B. M., Hutchison J. R., Straub T. M. 2015. “Construction of an in vitro primary lung co-culture platform derived from New Zealand white rabbits.” In Vitro Cellular & Developmental Biology-Animal 51: 433-440.

Powell J. D., Hutchison J. R., Hess B. M., Straub T. M. 2015. “Bacillus anthracis spores germinate extracellularly at air–liquid interface in an in vitro lung model under serum‐free conditions.” Journal of applied microbiology 119: 711-723.

Shelby M.B., Phillips C.B., Walker B., Wang G., Alfaro T., Stromberg Z. R., Hess B. M. 2022. “Engineered Cell Line Imaging Assay Differentiates Pathogenic from Non-Pathogenic Bacteria.” Pathogens 11: 209.

Wan K. H., Park S., Hess B. M., Neff M. J., Booth B. W., Celniker S. E. 2020. “Complete genome sequence of the Citrobacter freundii type strain.” Microbiology resource announcements 9: e00240-00220.

Wunschel D., Hutchison J., Kaiser B. D., Merkley E., Hess B., Lin A., Warner M. 2018. “Proteomic signatures differentiating Bacillus anthracis Sterne sporulation on soil relative to laboratory media.” Analyst 143: 123-132.

Yi L., Shi T., Gritsenko M. A., X’avia Chan C. -Y., Fillmore T. L., Hess B. M., Swensen A. C., Liu T, et al. 2018. “Targeted quantification of phosphorylation dynamics in the context of EGFR-MAPK pathway.” Analytical chemistry 90: 5256-5263.

Zhang T., Gaffrey M. J., Thomas D. G., Weber T. J., Hess B. M., Weitz K. K., Piehowski P. D., Petyuk V. A., et al. 2020. “A proteome-wide assessment of the oxidative stress paradigm for metal and metal-oxide nanomaterials in human macrophages.” NanoImpact 17: 100194.