Field asymmetric Ion mobility spectrometry (FAIMS), wherein ions are separated and/or characterized by differences in their mobility in high and low electric fields, is receiving increasing attention as a means of ion filtering and providing an additional level of separation in mass spectrometry analyses. PNNL has developed a number of patented technologies to improve the analytical capabilities of FAIMS devices and their interfacing with mass spectrometry instruments. These include:
- A patent covering the first successful coupling of a FAIMS device with an IMS drift tube device as a front-end separation method in a mass spectrometer instrument; substantially orthogonal separation of ions was achieved (U.S. Patent 7,148,474).
- A method and apparatus for aligning ions in a dipole direction within a FAIMS device so that the ions can be separated and/or characterized based on measurements other than their orientationally averaged cross-section (U.S. Patent 7,170,053).
- A method and apparatus for separating and characterizing ions based on their higher order differential mobility (U.S. Patent 7,449,683).
- New interfaces for FAIMS that substantially increase downstream ion transmission to subsequent MS or IMS devices (U.S. Patents 7,339,166 and 7,491,930).
- A method of operating a FAIMS device at lower pressures for better interfacing to a mass spectrometer and for electronically switching a FAIMS interface on and off when the interface is used in conjunction with a mass spectrometer (U.S. Patent 8,263,930).
- A patent covering the use of electric field counter flows to improve ion mobility resolution over a limited mass range.
Available for licensing in all fields
mass spectrometer sensitivity, mass spectrometer ion transmission, ion funnel, multiple capillary inlets, electrosprays, mass spectrometry, radio frequency, focus ions, natural gas, jet disturber; 14158-E, 14417-E, 14659-E, 14735-E, 15009-E, 15333-E, 15722-E; 6,818,890; 7,148,474; 7,170,053; 7,339,166; 7,491,930; 6,967,325; differential mobility separations; non-circular ion beams; ion mixtures; gas-phase separation; asymetric waveform; ion propulsion; dipole direction