This paper reports on the thermogelling, biodegradable polymer formulations based on poly(DL-lactic acid-co-glycolic acid)(poly(ethylene glycol) graft copolymers for in-vivo biomedical applications. The description includes diabetic control by sustained insulin delivery and cartilage repair by chondrocyte cell delivery. With one injection of the formula, the blood glucose level could be controlled from 5 to 16 days in diabetic rats by varying the polymer composition. Promising cartilage repair was observed using chondrocyte suspension in the thermogelling biodegradable depot.
Revised: March 2, 2004 |
Published: July 1, 2002
Citation
Jeong B., K.M. Lee, A. Gutowska, and Y.H. An. 2002.Thermogelling Biodegradable Copolymer Aqueous Solutions for Injectable Protein Delivery and Tissue Engineering.Biomacromolecules 3, no. 4:865-868. PNWD-SA-5654.