The goal of structural protoemics is to discover and better understand protein function by generating 3D structures of proteins on a genome-wide scale. To explore the feasibility of a comprehensive structural proteomics project, 424 non-membrane proteins of unknown structure from Methanobactereium thermoautotrophicum were cloned, expressed in E. coli and purified for structural studies.
Revised: May 31, 2001 |
Published: August 1, 2000
Citation
Christendat D., A. Yee, A. Dharamsi, A. Savchenko, V. Booth, C.D. Mackereth, and V. Saridakis, et al. 2000.Structural Proteomics of M. thermoautotrophicum: A global survey of nonmembrane protein expression, solubility and structure.Nature Structural Biology 7.PNNL-SA-32831.