Background: Side-chain oxysterols are key regulators of cellular cholesterol homeostasis with lipid-disordering membrane properties. Results: The side-chain oxysterol 25-hydroxycholesterol (25-HC) increases membrane cholesterol accessibility. Conclusions: Oxysterols regulate cholesterol accessibility by modulating the membrane environment. Significance: This work provides insight into how alterations in membrane structure can affect cellular cholesterol balance.
Revised: September 29, 2014 |
Published: April 23, 2014
Citation
Bielska A., B.N. Olsen, S.E. Gale, L. Mydock-McGrane, K. Krishnan, N.A. Baker, and P.H. Schlesinger, et al. 2014.Side-Chain Oxysterols Modulate Cholesterol Accessibility through Membrane Remodeling.Biochemistry 53, no. 18:3042–3051. PNWD-SA-10254. doi:10.1021/bi5000096