PNNL

Abstract

While a molecular assessment of the perturbations and injury arising from diseases is essential in their diagnosis and treatment, understanding changes due to preventative strategies is also imperative. Currently, complex diseases like cardiovascular disease (CVD), the leading cause of death worldwide, suffer from a limited understanding of how the molecular mechanisms taking place following preventive measures (e.g. exercise) differ from that occurring due to injury caused from the disease (e.g. myocardial infarction (MI)). Therefore, this manuscript assesses lipidomic changes before and one hour after exercise treadmill testing (ETT) and before and one hour after a planned myocardial infarction (PMI) in two separate patient cohorts. Strikingly different lipidomic perturbations were observed between these events as could be expected from their vastly different stresses on the body. The lipidomic results were then combined with previously published metabolomic characterizations on the same patients. This integration provided complementary insight into the exercise and PMI events, thereby giving a more holistic understanding of the molecular changes associated with each.