PNNL

Abstract

Continued expansion of the chemical biology toolbox presents many new and diverse opportu-nities to interrogate the fundamental molecular mechanisms driving complex plant–microbe in-teractions. This review will examine metabolic labeling with click chemistry reagents and activi-ty-based probes for investigating the impacts of plant-associated microbes on plant growth and metabolism. While the majority of the studies reviewed here used chemical biology approaches to examine the effects of pathogens on plants, chemical biology will also be invaluable in future efforts to investigate mutualistic associations between beneficial microbes and their plant hosts.