PNNL

Abstract

Gayrard et al. (2013) reported significant (~ 80%) absorption of bisphenol A (BPA) from solutions applied to the oral cavity of dogs, leading to higher serum BPA (aglycone) concentrations than occurred when BPA was absorbed through the gastrointestinal tract. This finding is consistent with first principles and experience with orally absorbed drugs. The implications for human exposure and health will be clear when experimental evidence is available regarding the extent and frequency of sublingual absorption in orally exposed humans. Arguments made by Gayrard et al. that “nanograms-per-milliliter” serum concentrations of BPA resulting from sublingual absorption are plausible in humans ignore key pharmacokinetic and exposure data and conflate issues of serum BPA concentrations with serum BPA/BPAG (BPA glucuronide) ratios.