Energetics and Dynamics of Peptide Fragmentation from Multiple-Collision Activation and Surface-Induced Dissociation Studies

June 10, 2004

Journal Article

Energetics and Dynamics of Peptide Fragmentation from Multiple-Collision Activation and Surface-Induced Dissociation Studies

Abstract

This account summarizes the energetics and dynamics of peptide fragmentation obtained using a new approach recently developed in our laboratory. The approach involves RRKM modeling of time- and energy-resolved MS/MS data obtained using collisional activation. We demonstrate that surface-induced dissociation (SID) on a long timescale of Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) is perfectly suited for studying the energetics and dynamics of peptide fragmentation.

Revised: October 31, 2007 | Published: June 10, 2004

Citation

Laskin J. 2004. Energetics and Dynamics of Peptide Fragmentation from Multiple-Collision Activation and Surface-Induced Dissociation Studies. European Journal of Mass Spectrometry 10, no. 2:259-267. PNNL-SA-39375. doi:10.1255/ejms.641