Trimethyltin chloride (TMT) is an organotin contaminant widely detected in aqueous environments posing potential human and environmental risk. In this study, we utilized the zebrafish model to investigate the impact of transient TMT exposure on developmental progression, angiogenesis, and cardiovascular development. Collectively, early life stage exposure to TMT perturbs numerous molecular pathways and result in apical vascular effects. These studies set the stage for functional dissection of the role of these validated TMT targets in mediating toxicological responses.
Revised: January 2, 2013 |
Published: December 16, 2012
Citation
Chen J., C. Huang, L. Truong, J.K. La Du, S.C. Tilton, K.M. Waters, and K. Lin, et al. 2012.Early Life Stage Trimethyltin Exposure Induces ADP-Ribosylation Factor Expression and Perturbs the Vascular System in Zebrafish.Toxicology 302, no. 2-3:129-139. PNWD-SA-9327. doi:10.1016/j.tox.2012.09.004