PNNL

Abstract

Beagle dogs exposed to 238PuO2 aerosols were observed throughout life to determine tissues at risk and dose-effect relationships. Although lungs accumulated a higher average radiation dose than skeleton, more deaths were due to bone tumors than lung tumors. The 50-year estimates for humans was an order of magnitude lower than doses at which increased incidence of neoplasia was observed in these dogs, whereas the projected doses to humans for deterministic effects were similar to those seen in the beagles.