May 30, 1997
Journal Article

Application of Sequential Paired Covariance to Liquid Chromatography-Mass Spectrometry Data: Enhancements in Both the signal-to-noise Ratio and the Resolution of Analyte Peaks in the Chromatogram

Abstract

The algorithm of sequential paired covariance (SPC) has been previously reported to dramatically enhance the signal-to-noise ratio for on-line separation combined with mass spectrometry. That initial study focused on a limited number of data sets derived from the combination of capillary electrophoresis (CE) with time-of-flight mass spectrometry usingan electrospray interface. This report further demonstrates the SPC approach to enhance the resolution as well as the S/N ration of the eluting peaks of a complex peptide mixture.

Revised: January 28, 2019 | Published: May 30, 1997

Citation

Muddiman D.C., B.M. Huang, G.A. Anderson, A.L. Rockwood, S.A. Hofstadler, M.S. Lipton, and A. Proctor, et al. 1997. Application of Sequential Paired Covariance to Liquid Chromatography-Mass Spectrometry Data: Enhancements in Both the signal-to-noise Ratio and the Resolution of Analyte Peaks in the Chromatogram. Journal of Chromatography A 771, no. 1-2:1-7. PNNL-SA-28334. doi:10.1016/S0021-9673(97)00069-1