June 1, 2008
Journal Article

Altered gene expression in the brain and liver of female fathead minnows Pimephales promelas Rafinesque exposed to fadrozole

Abstract

The fathead minnow (Pimephales promelas) is a small fish species widely used for ecotoxicology research and regulatory testing in North America. This study used a novel 2000 gene oligonucleotide microarray to evaluate the effects of the aromatase inhibitor, fadrozole, on gene expression in the liver and brain tissue of exposed females. Exposure to 60 ?g fadrozole/L for 7 d, resulted in the significant (p

Revised: September 3, 2008 | Published: June 1, 2008

Citation

Villeneuve D.L., I. Knoebl, P. Larkin, P. Larkin, A.L. Miracle, B.J. Carter, and N.D. Denslow, et al. 2008. Altered gene expression in the brain and liver of female fathead minnows Pimephales promelas Rafinesque exposed to fadrozole. Journal of Fish Biology 72, no. 9:2281-2340. PNNL-SA-56159. doi:10.1111/j.1095-8649.2008.01897.x