Chemist, Translational Omics Group Leader
Chemist, Translational Omics Group Leader

Biography

Yehia M. Ibrahim joined Pacific Northwest National Laboratory (PNNL) in 2005 as a postdoctoral researcher and has worked on the development of multiple technologies to enhance the sensitivity of drift tube ion mobility and mass spectrometry. He focuses on developing new capabilities using mass spectrometry and ion mobility technologies to improve the sensitivity and specificity of multi-omics applications. As a postdoctoral fellow, he developed ion funnel and ion funnel trap technologies to enhance drift tube ion mobility sensitivity and mass spectrometry, creating an ultrasensitive platform for biomolecule analysis. This platform received a 2013 R&D 100 award and was later licensed and commercialized by Agilent Technologies. His work has continued pushing the frontiers of mass-spectrometry-based technology to solve multi-omics challenges. Together with a team of scientists from PNNL, he successfully developed a highly sensitive ion mobility-Orbitrap mass spectrometer that included new multiplexing approaches for improved sensitivity. He has contributed to 37 patents and coauthored over 120 peer-reviewed manuscripts in mass and ion mobility spectrometry. Currently, he is leading research efforts to develop the Structures for Lossless Ion Manipulations technology, which received a 2017 R&D 100 award and was later licensed to MOBILion Systems Inc. through a 2018 Federal Laboratory Consortium Award for Excellence in Technology Transfer. He has collaborated with leading industry vendors such as Agilent and ThermoFisher and successfully led many projects funded both internally and externally (e.g., from the National Institutes of Health). 

Research Interest

  • Mass spectrometry 
  • Ion mobility 
  • Metabolomics 
  • Proteomics 
  • Ion manipulations

Disciplines and Skills

  • Ion Mobility
  • FAIMS
  • Technology development
  • Proteomics
  • Metabolomics

Education

  • MS, Physical Chemistry, Cairo University
  • PhD, Physical Chemistry, Virginia Commonwealth University

Affiliations and Professional Service

  • The American Society for Mass Spectrometry
  • The American Chemical Society
  • The American Association for the Advancement of Science

Awards and Recognitions

  • 2019 Inventor of the Year, PNNL
  • 2019 Distinguished Inventor of Battelle
  • Federal Laboratory Consortium Award for Excellence in Technology Transfer (2018)
  • Mentor of the Year, PNNL (2016)
  • Key Contributor Award 2012, 2013, 2014, 2015
  • Two R&D 100 Awards (2013 and 2017)
  • Resident Research Associateship from the National Research Council at NIST (National Institute of Standards and Technology) and NIH (National Institute of Health)
  • Graduate School Research Fellowship, Virginia Commonwealth University
  • Bass Scholarship, Virginia Commonwealth University
  • Chairman Award in Gordon Conference on Gaseous Ions: Structure, Energetics & Reactions (2003)

Patents

  • Belov, Mikhail E., Yehia M. Ibrahim, Biran H. Clowers, David C. Prior, and Richard D. Smith. Ion Funnel Ion Trap and Process. U.S. Patent US7888635B2, filed 30 May 2008, issued 15 February 2011. https://patents.google.com/patent/US7888635B2/
  • Shvartzburg, Alexandre A., Keqi Tang, Yehia M. Ibrahim, and Richard D. Smith. Hooked Differential Mobility Spectrometry Apparatus and Method. U.S. Patent US7491930B2, filed 29 December 2006, issued 17 February 2009. https://patents.google.com/patent/US7491930B2/
  • Ibrahim, Yehia M., Mikhail E. Belov, and David C. Prior. System and Method for Collisional Activation of Charged Particles. U.S. Patent US8541737B2, filed 28 April 2010, issued 24 September 2013. https://patents.google.com/patent/US8541737B2/
  • Webb, Ian K., Yehia M. Ibrahim, Keqi Tang, Gordon A. Anderson, and Richard D. Smith. Apparatus and Method of Dissociating Ions in a Multipole Ion Guide. U.S. Patent US8772711B1, filed 27 August 2013, issued 8 July 2014. https://patents.google.com/patent/US8772711B1/
  • Anderson, Gordon A., Richard D. Smith, Yehia M. Ibrahim, and Erin M. Baker. Ion Manipulation Device. U.S. Patent US8835839B1, filed 3 January 2014, issued 9 October 2014. https://patents.google.com/patent/US8835839B1/
  • Tolmachev, Aleksey, Richard D. Smith, Yehia M. Ibrahim, Gordon A. Anderson, and Erin M. Baker. Ion Manipulation Device to Prevent Loss of Ions. U.S. Patent US8969800B1, filed 30 October 2014, issued 3 March 2015. https://patents.google.com/patent/US8969800B1/
  • Chen, Tsung-Chi, Keqi Tang, Yehia M. Ibrahim, Richard D. Smith, Gordon A. Anderson, and Erin M. Baker. Vacuum Chamber for Ion Manipulation Device. U.S. Patent US8907273B1, filed 30 May 2014, issued 9 December 2014. https://patents.google.com/patent/US8907273B1/
  • Chen, Tsung-Chi, Keqi Tang, Yehia M. Ibrahim, Richard D. Smith, Gordon A. Anderson, and Erin M. Baker. Ion Manipulation Device with Electrical Breakdown Protection. U.S. Patent US8901490B1, filed 30 May 2014, issued 2 December 2014. https://patents.google.com/patent/US8901490B1/
  • Garimella, Sandilya V.B., Yehia M. Ibrahim, Gordon A. Anderson, and Richard D. Smith. Methods for Ion Peak Compression for High Resolution Ion Mobility Spectrometry. U.S. Patent US9063086B1, filed 12 February 2014, issued 23 June 2015. https://patents.google.com/patent/US9063086B1/
  • Ibrahim, Yehia M., and Richard D. Smith. Ion Trap Device. U.S. Patent US9245725B2, filed 12 February 2014, issued 26 January 2016. https://patents.google.com/patent/US9245725B2/
  • Ibrahim, Yehia M., and Richard D. Smith. Device for Separating Non-Ions From Ions. U.S. Patent US9558925B2, filed 18 April 2014, issued 31 January 2017, https://patents.google.com/patent/US9558925B2/
  • Ibrahim, Yehia M., Sandilya V.B. Garimella, and Richard D. Smith. Method and Device for Ion Mobility Separations. U.S. Patent US9704701B2, filed 11 September 2015, issued 11 July 2017. https://patents.google.com/patent/US9704701B2/
  • Anderson, Gordon A., Erin M. Baker, Richard D. Smith, and Yehia M. Ibrahim. Ion Manipulation Method Device. U.S. Patent US9812311B2, filed 13 January 2014, issued 7 November 2017. https://patents.google.com/patent/US9812311B2/
  • Ibrahim, Yehia M., Tsung-Chi Chen, Marques B. Harrer, Keqi Tang, and Richard D. Smith. Ion Funnel Device. U.S. Patent US9824874B2, filed 8 June 2015, issued 21 November 2017. https://patents.google.com/patent/US9824874B2/
  • Ibrahim, Yehia M., Sandilya Garimella, and Spencer A. Prost. Systems and Methods for Integrating Ion Mobility and Ion Trap Mass Spectrometers. U.S. Patent US9939409B2, filed 3 August 2016, issued 10 April 2018. https://patents.google.com/patent/US9939409B2/
  • Anderson, Gordon A., Erin M. Baker, Richard D. Smith, and Yehia M. Ibrahim. Ion Manipulation Device. U.S. Patent US9966244B2, filed 23 October 2017, issued 8 May 2018. https://patents.google.com/patent/US9966244B2/
  • Ibrahim, Yehia M., Sandilya Garimella, and Richard D. Smith. Method and Apparatus for Spatial Compression and Increased Mobility Resolution of Ions. U.S. Patent US10018592B2, filed 17 May 2016, issued 10 July 2018. https://patents.google.com/patent/US10018592B2/
  • Ibrahim, Yehia M., and Richard D. Smith. Device to Manipulate Ions of Same or Different Polarities. U.S. Patent US10224194B2, filed 8 September 2016, issued 5 March 2019. https://patents.google.com/patent/US10224194B2/
  • Garimella, Venkata B.S., Ahmed M. Hamid, Yehia M. Ibrahim, and Richard D. Smith. Method and Apparatus for Ion Mobility Separations Utilizing Alternating Current Waveforms. U.S. Patent US10317364B2, filed 15 August 2016, issued 11 June 2019. https://patents.google.com/patent/US10317364B2/
  • Ibrahim, Yehia M., and Richard D. Smith. Ion Focusing Device. U.S. Patent US10332723B1, filed 20 December 2017, issued 25 June 2019. https://patents.google.com/patent/US10332723B1/
  • Ibrahim, Yehia M., Sandilya V.B. Garimella, and Richard D. Smith. Method and Device For Ion Mobility Separation. U.S. Patent US10424474B2, filed 5 February 2016, issued 24 September 2019. https://patents.google.com/patent/US10424474B2/
  • Smith, Richard D., Sandilya V.B. Garimella, and Yehia M. Ibrahim. Flexible Ion Conduit. U.S. Patent US10460920B1, filed 26 June 2018, issued 29 October 2019. https://patents.google.com/patent/US10460920B1/
  • Ibrahim, Yehia M., Sandilya V.B. Garimella, and Richard D. Smith. Method and Apparatus for Spatial Compression and Increased Mobility Resolution Of Ions. U.S. Patent US10466202B2, filed 3 July 2018, issued 5 November 2019. https://patents.google.com/patent/US10466202B2/
  • Ibrahim Yehia M., Aneesh Prabhakaran, Sandilya V.B. Garimella, Richard D. Smith, and Ailin Li. Methods and Systems for Ion Manipulation. U.S. Patent US10497552B2, filed 14 August 2018, issued 3 December 2019. https://patents.google.com/patent/US10497552B2/
  • Ibrahim, Yehia M., and Richard D. Smith. Device to Manipulate Ions of Same or Different Polarities. U.S. Patent US10665443B2, filed 28 February 2019, issued 26 May 2020. https://patents.google.com/patent/US10665443B2/
  • Prabhakaran, Aneesh, Yehia M. Ibrahim, and Sandilya V.B. Garimella. Frequency Modulated Radio Frequency Electric Field for Ion Manipulation. U.S. Patent US10692710B2, filed 16 November 2018, issued 23 June 2020. https://patents.google.com/patent/US10692710B2/
  • Ibrahim, Yehia M., and Richard D. Smith. Methods and Systems for Integrating Ion Manipulation Devices. U.S. Patent US10804089B2, filed 11 July 2018, issued 13 October 2020. https://patents.google.com/patent/US10804089B2/
  • Ibrahim, Yehia M., Sandilya Garimella, and Richard D. Smith. Method and Apparatus for Spatial Compression and Increased Mobility Resolution of Ions. U.S. Patent US10976283B2, filed 4 November 2019, issued 13 April 2021. https://patents.google.com/patent/US10976283B2/
  • Ibrahim, Yehia M., Adam L. Hollerbach, and Ailin Li. Device and Method to Manipulate Ions in Multi-Level System. U.S. Patent US11119069B2, filed 25 October 2019, issued 14 September 2021. https://patents.google.com/patent/US11119069B2/
  • Garimella, Venkata B.S., Ahmed M. Hamid, Yehia M. Ibrahim, and Richard D. Smith. Method and Apparatus for Ion Mobility Separations Utilizing Alternating Current Waveforms. U.S. Patent US11209393B2, filed 6 May 2019, issued 28 December 2021. https://patents.google.com/patent/US11209393B2/
  • Hollerbach, Adam L., Yehia M. Ibrahim, and Sandilya V.B. Garimella. Atmospheric Pressure Ion Focusing Device Employing Nonlinear DC Voltage Sequences. U.S. Patent US11480544B2, filed 5 February 2020, issued 25 October 2022. https://patents.google.com/patent/US11480544B2/
  • Ibrahim, Yehia M., Adam L. Hollerbach, and Ailin Li. Device and Method to Manipulate Ions in Multi-Level System. U.S. Patent US11796504B2, filed 11 August 2021, issued 24 October 2023. https://patents.google.com/patent/US11796504B2/
  • Garimella, Venkata B.S., Ahmed M. Hamid, Yehia M. Ibrahim, and Richard D. Smith. Method and Apparatus for Ion Mobility Separations Utilizing Alternating Current Waveforms. U.S. Patent US11761925B2, filed 21 December 2021, issued 19 September 2023. https://patents.google.com/patent/US11761925B2/ 
  • Ibrahim, Yehia M., and Richard D. Smith. Ion Focusing Device. U.S. Patent US11605531B2, filed 13 December 2018, issued 14 March 2023. https://patents.google.com/patent/US11605531B2/
  • Garimella, Sandilya V.B., Yehia M. Ibrahim, Ailin Li, and Richard D. Smith. Systems and Methods for Selective Molecular Ion Deposition. U.S. Patent US12354835B2, filed 7 May 2021, issued 8 July 2025. https://patents.google.com/patent/US12354835B2/

Ibrahim, Yehia M. Curved Ion Mobility Architecture. U.S. Patent US12381072B2, filed 8 July 2022, issued 5 August 2025. https://patents.google.com/patent/US12381072B2/

Publications

2025

  • Harrilal, C. P., S. V. B. Garimella, R. V. Norheim, R. V., and Y. M. Ibrahim. 2025. “Development of a Platform for High-Resolution Ion Mobility Separations Coupled with Messenger Tagging Infrared Spectroscopy for High-Precision Structural Characterizations.” Analytical Chemistry 97 (4): 2103-2110. https://doi.org/10.1021/acs.analchem.4c04780.
  • Lee, J.-Y., S. V. B. Garimella, R. V. Norheim, and Y. M. Ibrahim. 2025. “Characterization of Mobility-Dependent Ion Confinement in Rotating Electric Fields.” Journal of the American Society for Mass Spectrometry 36 (12): 2675–2681. https://doi.org/10.1021/jasms.5c00281.
  • Hollerbach, A. L., A. Prabhakaran, R. V. Norheim, A. G. Ryan, J. M. Lindquist, and Y. M. Ibrahim. 2025. “Transmitting and Filtering Ions in the Open Air by Applying Spirally Rotating Electric Fields to a Flexible and Segmented Stacked Ring Ion Guide.” Analytical Chemistry 97 (40): 22041-22050. https://doi.org/10.1021/acs.analchem.5c03706.
  • Harrilal, C. P., I. K. Attah, P. Kwantwi-Barima, R. Kurulugama, and Y. M. Ibrahim. 2025. “Performance Evaluation of Constant Field and Traveling Wave-Based Structures for Lossless Ion Manipulations Devices Coupled to Mass Spectrometry.” Journal of the American Society of Mass Spectrometry 36 (11): 2568-2577. https://doi.org/10.1021/jasms.5c00273.

2024

  • Kwantwi-Barima, P., S. V. B. Garimella, I. K. Attah, X. Zheng, Y. M. Ibrahim, and R. D. Smith. 2024. “Accumulation of Large Ion Populations with High Ion Densities and Effects Due to Space Charge in Traveling Wave-Based Structures for Lossless Ion Manipulations (SLIM) IMS-MS.” Journal of the American Society Mass Spectrometry 35 (2): 365-377. https://doi.org/10.1021/jasms.3c00389
  • Huntley, A. P., A. L. Hollerbach, R. V. Norheim, A. M. Hamid, G. A. Anderson, S. V. B. Garimella, and Y. M. Ibrahim. 2024. “Cyclable Variable Path Length Multilevel Structures for Lossless Ion Manipulations (SLIM) Platform for Enhanced Ion Mobility Separations.” Analytical Chemistry 96 (7): 3160-3167. https://doi.org/10.1021/acs.analchem.3c05594.
  • Lee, J. Y., A. Li, V. Prabhakaran, X. Zhang, C. P. P. Harrilal, L. Kovarik, Y. M. Ibrahim, R. D. Smith, and S. V. B. Garimella. 2024. “Mobility Selective Ion Soft-Landing and Characterization Enabled Using Structures for Lossless Ion Manipulation.” Analytical Chemistry 96 (8): 3373-3381. https://doi.org/10.1021/acs.analchem.3c04328.
  • Hollerbach, A. L., Y. M. Ibrahim, V. S. Lin, K. J. Schultz, A. P. Huntley, P. B. Armentrout, T. O. Metz, and R. G. Ewing. 2024. “Identification of Unique Fragmentation Patterns of Fentanyl Analog Protomers Using Structures for Lossless Ion Manipulations Ion Mobility-Orbitrap Mass Spectrometry.” Journal of the American Society for Mass Spectrometry 35 (4): 793-803. https://doi.org/10.1021/jasms.4c00049.
  • Kwantwi-Barima, P., A. L. Hollerbach, I. K. Attah, R. V. Norheim, and Y. M. Ibrahim. 2024. “Ion Mobility Separations Using Cocentric Architecture.” Journal of the American Society for Mass Spectrometry 35 (7): 1576-1583. https://doi.org/10.1021/jasms.4c00163.
  • Ross, D. H., J. Y. Lee, Y. Gao, A. L. Hollerbach, A. Bilbao, T. Shi, Y. M. Ibrahim, R. D. Smith, and X. Zheng. 2024. “Evaluation of a Reference-Free Collision Cross Section Calibration Strategy for Proteomics Using SLIM-Based High-Resolution Ion Mobility Spectrometry–Mass Spectrometry.” Journal of the American Society for Mass Spectrometry 35 (7): 1539-1549. https://doi.org/10.1021/jasms.4c00141.
  • Hollerbach, A. L., V. S. Lin, Y. M. Ibrahim, R. G. Ewing, T. O. Metz, and K. E. Rodda. 2024. “Elucidating the Gas-Phase Behavior of Nitazene Analog Protomers Using Structures for Lossless Ion Manipulations Ion Mobility-Orbitrap Mass Spectrometry.” Journal of the American Society for Mass Spectrometry 35 (7): 1609-1621. https://doi.org/10.1021/jasms.4c00200.

2023

  • Huntley, A. P., A. L. Hollerbach, A. Prabhakaran, S. V. B. Garimella, C. M. Giberson, R. V. Norheim, R. D. Smith, and Y. M. Ibrahim. 2023. “Development of a Structure for Lossless Ion Manipulations (SLIM) High Charge Capacity Array of Traps.” Analytical Chemistry 95 (9): 4446-4453. https://doi.org/10.1021/acs.analchem.2c05025.
  • Hollerbach, A. L., Y. M. Ibrahim, V. Meras, R. V. Norheim, A. P. Huntley, G. A. Anderson, T. O. Metz, R. G. Ewing, and R. D. Smith. 2023. “A Dual-Gated Structures for Lossless Ion Manipulations-Ion Mobility Orbitrap Mass Spectrometry Platform for Combined Ultra-High-Resolution Molecular Analysis.” Analytical Chemistry 95 (25): 9531-9538. https://doi.org/10.1021/acs.analchem.3c00881.
  • Harrilal, C. P., S. V. B. Garimella, J. Chun, N. Devanathan, X. Zheng, Y. M. Ibrahim, C. Larriba-Andaluz, G. Schenter, and R. D. Smith. 2023. “The Role of Ion Rotation in Ion Mobility: Ultrahigh-Precision Prediction of Ion Mobility Dependence on Ion Mass Distribution and Translational to Rotational Energy Transfer.” The Journal of Physical Chemistry A 127 (25): 5458-5469. https://doi.org/10.1021/acs.jpca.3c01264.
  • Kwantwi-Barima, P., S. V. B. Garimella, I. K. Attah, and Y. M. Ibrahim. 2023. “Evaluating Ion Accumulation and Storage in Traveling Wave Based Structures for Lossless Ion Manipulations.” Journal of the American Society for Mass Spectrometry 34 (12): 2849-2856. https://doi.org/10.1021/jasms.3c00348.

2022

  • Bilbao, A., B. C. Gibbons, S. M. Stow, J. E. Kyle, K. J. Bloodsworth, S. H. Payne, R. D. Smith, Y. M. Ibrahim, E. S. Baker, and J. C. Fjeldsted. 2022. “A Preprocessing Tool for Enhanced Ion Mobility–Mass Spectrometry-Based Omics Workflows.” Journal of Proteome Research 21 (3): 798-807. https://doi.org/10.1021/acs.jproteome.1c00425.
  • Hollerbach, A. L., R. V. Norheim, P. Kwantwi-Barima, R. D. Smith, and Y. M. Ibrahim. 2022. “A Miniature Multilevel Structures for Lossless Ion Manipulations Ion Mobility Spectrometer with Wide Mobility Range Separation Capabilities.” Analytical Chemistry, 94 (4): 2180-2188. https://doi.org/10.1021/acs.analchem.1c04700.
  • Colby, S. M., C. H. Chang, J. L. Bade, J. R. Nunez, M. R. Blumer, D. J. Orton, K. J. Bloodsworth, E. S. Nakayasu, R. D. Smith, Y. M. Ibrahim, R. S. Renslow, and T. O. Metz. 2022. “DEIMoS: An Open-Source Tool for Processing High-Dimensional Mass Spectrometry Data.” Analytical Chemistry 94 (16): 6130-6138. https://doi.org/10.1021/acs.analchem.1c05017.
  • Kwantwi-Barima, P., C. P. Harrilal, S. V. B. Garimella, I. K. Attah, R. D. Smith, and Y. M. Ibrahim. 2022. “Effect of Traveling Waveform Profiles on Collision Cross Section Measurements in Structures for Lossless Ion Manipulations.” Journal of the American Society for Mass Spectrometry 33 (5): 783-792. https://doi.org/10.1021/jasms.1c00364.
  • Giberson, C., R. K. Singh, J. Chun, A. P. Huntley, J. Zhong, Y. M. Ibrahim, G. K. Schenter, J.-Y. Lee, and S. V. B. Garimella. 2022. “SimELIT: A Novel GUI-Based Comprehensive Ion Trajectory Simulation Software for Mass Spectrometry.” Journal of the American Society for Mass Spectrometry 33 (8): 1453-1457. https://doi.org/10.1021/jasms.1c00301.
  • Bilbao, A., D. H. Ross, J.-Y. Lee, M. T. Donor, S. M. Williams, Y. Zhu, Y. M. Ibrahim, R. D. Smith, and X. Zheng. 2022. “MZA: A Data Conversion Tool to Facilitate Software Development and Artificial Intelligence Research in Multidimensional Mass Spectrometry.” Journal of Proteome Research 22 (2): 508–513. https://doi.org/10.1021/acs.jproteome.2c00313.
  • Hollerbach, A. L., Y. M. Ibrahim, R. V. Norheim, T. O. Metz, and R. G. Ewing. 2022. “Focusing Ions at Atmospheric Pressure Using Nonlinear DC Voltage Sequences Applied to a Stacked Ring Ion Guide.” International Journal Mass Spectrometry 482: 116948. https://doi.org/10.1016/j.ijms.2022.116948.

2021

  • Conant, C. R., I. K. Attah, S. V. B. Garimella, G. Nagy, A. Bilbao, R. D. Smith, and Y. M. Ibrahim. 2021. “Evaluation of Waveform Profiles for Traveling Wave Ion Mobility Separations in Structures for Lossless Ion Manipulations.” Journal of the American Society for Mass Spectrometry 32 (1): 225-236. https://doi.org/10.1021/jasms.0c00282.
  • Hollerbach, A. L., C. R. Conant, G. Nagy, M. E. Monroe, K. Gupta, M. Donor, C. M. Giberson, S. V. B. Garimella, R. D. Smith, and Y. M. Ibrahim. 2021. “Dynamic Time-Warping Correction for Shifts in Ultrahigh Resolving Power Ion Mobility Spectrometry and Structures for Lossless Ion Manipulations.” Journal of the American Society for Mass Spectrometry 32 (4): 996-1007. https://doi.org/10.1021/jasms.1c00005.
  • Taylor, M. J., S. Mattson, A. Liyu, S. A. Stopka, Y. M. Ibrahim, A. Vertes, and C. R. Anderton. 2021. “Optical Microscopy-Guided Laser Ablation Electrospray Ionization Ion Mobility Mass Spectrometry: Ambient Single Cell Metabolomics with Increased Confidence in Molecular Identification.” Metabolites 11 (4), 200. https://doi.org/10.3390/metabo11040200.
  • Lee, J.-Y., A. Bilbao, C. R. Conant, K. J. Bloodsworth, D. J. Orton, M. Zhou, J. W. Wilson, X. Zheng, I. K. Webb, A. Li, K. K. Hixson, J. C. Fjeldsted, Y. M. Ibrahim, S. H. Payne, C. Jansson, R. D. Smith, and T. O. Metz. 2021. “AutoCCS: Automated Collision Cross-Section Calculation Software for Ion Mobility Spectrometry–Mass Spectrometry.” Bioinformatics 37 (22): 4193-4201. https://doi.org/10.1093/bioinformatics/btab429.
  • Hollerbach, A. L., C. M. Giberson, J.-Y. Lee, A. P. Huntley, R. D. Smith, and Y. M. Ibrahim. 2021. “Improving Signal to Noise Ratios in Ion Mobility Spectrometry and Structures for Lossless Ion Manipulations (SLIM) using a High Dynamic Range Analog-to-Digital Converter.” Journal of the American Society for Mass Spectrometry 32 (11): 2698-2706. https://doi.org/10.1021/jasms.1c00226.
  • Harrilal, C. P., V. D. Gandhi, G. Nagy, X. Chen, M. G. Buchanan, R. Wojcik, C. R. Conant, M. T. Donor, Y. M. Ibrahim, S. V. B. Garimella, R. D. Smith, and C. Larriba-Andaluz. 2021. “Measurement and Theory of Gas-Phase Ion Mobility Shifts Resulting from Isotopomer Mass Distribution Changes.” Analytical Chemistry 93 (45): 14966-14975. 

2020

  • Li A., V. Garimella, and Y.M. Ibrahim. 2020. "A Simulation Study of the Influence of the Traveling Wave Patterns on Ion Mobility Separations in Structures for Lossless Ion Manipulations." Analyst 145, no. 1:240-248. PNNL-SA-145853. doi:10.1039/C9AN01509D
  • Nagy, G., I. K. Attah, C. R. Conant, W. Liu, S. V. B. Garimella, H. P. Gunawardena, J. B. Shaw, R. D. Smith, and Y. M. Ibrahim. 2020. “Rapid and Simultaneous Characterization of Drug Conjugation in Heavy and Light Chains of a Monoclonal Antibody Revealed by High-Resolution Ion Mobility Separations in SLIM.” Analytical Chemistry 2020, 92 (7), 5004-5012. https://doi.org/10.1021/acs.analchem.9b05209.
  • Hollerbach, A. L., A. Li, A. Prabhakaran, G. Nagy, C. P. Harrilal, C. R. Conant, R. V. Norheim, C. E. Schimelfenig, G. A. Anderson, S. V. B. Garimella, R. D. Smith, and Y. M. Ibrahim. 2020. “Ultra-High-Resolution Ion Mobility Separations Over Extended Path Lengths and Mobility Ranges Achieved using a Multilevel Structures for Lossless Ion Manipulations Module.” Analytical Chemistry 92 (11): 7972-7979. https://doi.org/10.1021/acs.analchem.0c01397.
  • Li, A., C. R. Conant, X. Zheng, K. J. Bloodsworth, D. J. Orton, S. V. B. Garimella, I. K. Attah, G. Nagy, R. D. Smith, and Y. M. Ibrahim. 2020. “Assessing Collision Cross Section Calibration Strategies for Traveling Wave-Based Ion Mobility Separations in Structures for Lossless Ion Manipulations.” Analytical Chemistry 2020, 92 (22): 14976-14982. https://doi.org/10.1021/acs.analchem.0c02829.

2019

  • Attah I.K., V. Garimella, I.K. Webb, G. Nagy, R.V. Norheim, C.E. Schimelfenig, and Y.M. Ibrahim, et al. 2019. "Dual Polarity Ion Confinement and Mobility Separations." Journal of the American Society for Mass Spectrometry 30, no. 6:967-976. PNNL-SA-132014. doi:10.1007/s13361-019-02138-1
  • Couvillion S.P., Y. Zhu, G. Nagy, J.N. Adkins, C.K. Ansong, R.S. Renslow, and P.D. Piehowski, et al. 2019. "New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells." Analyst 144, no. 3:794-807. PNNL-SA-137430. doi:10.1039/C8AN01574K
  • Dou M., C.D. Chouinard, Y. Zhu, G. Nagy, A.V. Liyu, Y.M. Ibrahim, and R.D. Smith, et al. 2019. "Nanowell-mediated multidimensional separations combining nanoLC with SLIM IM-MS for rapid, high-peak-capacity proteomic analyses." Analytical and Bioanalytical Chemistry 411, no. 21:5363-5372. PNNL-SA-146403. doi:10.1007/s00216-018-1452-5
  • Garcellano R.C., S. Moinuddin, R.P. Young, M.E. Bowden, M. Zhou, R.S. Renslow, and Y. Yesiltepe, et al. 2019. "Isolation of Tryptanthrin and Reassessment of Evidence for its Isobaric Isostere Wrightiadione in Plants of the Wrightia Genus." Journal of Natural Products 82, no. 3:440-448. PNNL-SA-135279. doi:10.1021/acs.jnatprod.8b00567
  • Garimella V., G. Nagy, Y.M. Ibrahim, and R.D. Smith. 2019. "Opening new paths for biological applications of ion mobility - Mass spectrometry using structures for lossless ion manipulations." Trends in Analytical Chemistry. TrAC 116. PNNL-SA-140349. doi:10.1016/j.trac.2019.04.021
  • Nagy G., D. Velickovic, R.K. Chu, A.A. Carrell, D.J. Weston, Y.M. Ibrahim, and C.R. Anderton, et al. 2019. "Towards Resolving the Spatial Metabolome with Unambiguous Molecular Annotations in Complex Biological Systems by Coupling Mass Spectrometry Imaging with Structures for Lossless Ion Manipulations." Chemical Communications 55, no. 3:306-309. PNNL-SA-138045. doi:10.1039/C8CC07482H
  • Nagy G., K. Kedia, I.K. Attah, V. Garimella, Y.M. Ibrahim, V.A. Petyuk, and R.D. Smith. 2019. "Separation of ß-Amyloid Tryptic Peptide Species with Isomerized and Racemized L-Aspartic Residues with Ion Mobility in Structures for Lossless Ion Manipulations." Analytical Chemistry 91, no. 7:4374-4380. PNNL-SA-138885. doi:10.1021/acs.analchem.8b04696
  • Wojcik R., G. Nagy, I.K. Attah, I.K. Webb, V. Garimella, K.K. Weitz, and A.L. Hollerbach, et al. 2019. "SLIM Ultrahigh Resolution Ion Mobility Spectrometry Separations of Isotopologues and Isotopomers Reveal Mobility Shifts due to Mass Distribution Changes." Analytical Chemistry 91, no. 18:11952-11962. PNNL-SA-147394. doi:10.1021/acs.analchem.9b02808

2018

  • Bilbao Pena A., B.C. Gibbons, G.W. Slysz, K.L. Crowell, M.E. Monroe, Y.M. Ibrahim, and R.D. Smith, et al. 2018. "An Algorithm to Correct Saturated Mass Spectrometry Ion Abundances for Enhanced Quantitation and Mass Accuracy in Omic Studies." International Journal of Mass Spectrometry 427. PNNL-SA-126312. doi:10.1016/j.ijms.2017.11.003
  • Chouinard C.D., G. Nagy, I.K. Webb, T. Shi, E.M. Baker, S.A. Prost, and T. Liu, et al. 2018. "Improved Sensitivity and Separations for Phosphopeptides using Online Liquid Chromotography Coupled with Structures for Lossless Ion Manipulations Ion Mobility-Mass Spectrometry." Analytical Chemistry 90, no. 18:10889-10896. PNNL-SA-135107. doi:10.1021/acs.analchem.8b02397
  • Chouinard C.D., G. Nagy, I.K. Webb, V. Garimella, E.M. Baker, Y.M. Ibrahim, and R.D. Smith. 2018. "Rapid Ion Mobility Separations of Bile Acid Isomers Using Cyclodextrin Adducts and Structures for Lossless Ion Manipulations." Analytical Chemistry 90, no. 18:11086-11091. PNNL-SA-136059. doi:10.1021/acs.analchem.8b02990
  • Hamid A.M., A. Prabhakaran Nair Syamala Amma, V. Garimella, Y.M. Ibrahim, and R.D. Smith. 2018. "Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM)." International Journal of Mass Spectrometry 430. PNNL-SA-127372. doi:10.1016/j.ijms.2018.03.006
  • Nagy G., C.D. Chouinard, I.K. Attah, I.K. Webb, V. Garimella, Y.M. Ibrahim, and E.M. Baker, et al. 2018. "Distinguishing Enantiomeric Amino Acids with Chiral Cyclodextrin Adducts and Structures for Lossless Ion Manipulations." Electrophoresis 39, no. 24:3148-3155. PNNL-SA-136376. doi:10.1002/elps.201800294
  • Nagy G., I.K. Attah, V. Garimella, K. Tang, Y.M. Ibrahim, E.M. Baker, and R.D. Smith. 2018. "Unraveling the Isomeric Heterogeneity of Glycans: Ion Mobility Separations in Structures for Lossless Ion Manipulations." Chemical Communications 54, no. 83:11701-11704. PNNL-SA-137134. doi:10.1039/C8CC06966B
  • Prabhakaran Nair Syamala Amma A., A.M. Hamid, V. Garimella, B.R. Valenzuela, R.G. Ewing, Y.M. Ibrahim, and R.D. Smith. 2018. "A Hybrid Constant and Oscillatory Field Ion Mobility Analyzer in Structures for Lossless Ion Manipulations." Journal of the American Society for Mass Spectrometry 29, no. 2:342-351. PNNL-SA-126448. doi:10.1007/s13361-017-1841-6

2017

  • Deng L., I.K. Webb, V. Garimella, A.M. Hamid, X. Zheng, R.V. Norheim, and S.A. Prost, et al. 2017. "Serpentine Ultralong Path with Extended Routing (SUPER) High Resolution Traveling Wave Ion Mobility-MS using Structures for Lossless Ion Manipulations." Analytical Chemistry 89, no. 8:4628-4634. PNNL-SA-123438. doi:10.1021/acs.analchem.7b00185
  • Deng L., V. Garimella, A.M. Hamid, I.K. Webb, I.K. Attah, R.V. Norheim, and S.A. Prost, et al. 2017. "Compression Ratio Ion Mobility Programming (CRIMP) Accumulation and Compression of Billions of Ions for Ion Mobility-Mass Spectrometry Using Traveling Waves in Structures for Lossless Ion Manipulations (SLIM)." Analytical Chemistry 89, no. 12:6432-6439. PNNL-SA-123357. doi:10.1021/acs.analchem.7b00189
  • Garimella V., I.K. Webb, A. Prabhakaran Nair Syamala Amma, I.K. Attah, Y.M. Ibrahim, and R.D. Smith. 2017. "Design of a TW-SLIM Module for Dual Polarity Confinement, Transport, and Reactions." Journal of the American Society for Mass Spectrometry 28, no. 7:1442-1449. PNNL-SA-123670. doi:10.1007/s13361-017-1680-5
  • Hosseinzadeh P., G. Bhardwaj, V.K. Mulligan, M.D. Shortridge, T.W. Craven, F. Pardo-Avila, and S.A. Rettie, et al. 2017. "Comprehensive computational design of ordered peptide macrocycles." Science 358, no. 6369:1461-1466. PNNL-SA-128820. doi:10.1126/science.aap7577
  • Ibrahim Y.M., A.M. Hamid, J.T. Cox, V. Garimella, and R.D. Smith. 2017. "Ion Elevators and Escalators in Multi-level Structures for Lossless Ion Manipulations." Analytical Chemistry 89, no. 3:1972-1977. PNNL-SA-122334. doi:10.1021/acs.analchem.6b04500
  • Ibrahim Y.M., A.M. Hamid, L. Deng, V. Garimella, I.K. Webb, E.M. Baker, and R.D. Smith. 2017. "New Frontiers for Mass Spectrometry based upon Structures for Lossless Ion Manipulations." Analyst 142, no. 7:1010-1021. PNNL-SA-123137. doi:10.1039/C7AN00031F
  • Kyle J.E., C.P. Casey, K.G. Stratton, E.M. Zink, Y. Kim, X. Zheng, and M.E. Monroe, et al. 2017. "Comparing Identified and Statistically Significant Lipids and Metabolites in 15-Year Old Serum and Dried Blood Spot Samples for Longitudinal Studies." Rapid Communications in Mass Spectrometry 31, no. 5:447-456. PNNL-SA-121197. doi:10.1002/rcm.7808
  • Ma J., C.P. Casey, X. Zheng, Y.M. Ibrahim, C.S. Wilkins, R.S. Renslow, and D.G. Thomas, et al. 2017. "PIXiE: An Algorithm for Automated Ion Mobility Arrival Time Extraction and Collision Cross Section Calculation using Global Data Association." Bioinformatics 33, no. 17:2715-2722. PNNL-SA-122828. doi:10.1093/bioinformatics/btx305
  • Tummalacherla M., V. Garimella, S.A. Prost, and Y.M. Ibrahim. 2017. "Toward Artifact-Free Data in Hadamard Transform-Based Double Multiplexing of Ion Mobility - Orbitrap Mass Spectrometry." Analyst 142, no. 10:1735-1745. PNNL-SA-123964. doi:10.1039/C7AN00289K
  • Zheng X., L. Deng, E.M. Baker, Y.M. Ibrahim, V.A. Petyuk, and R.D. Smith. 2017. "Distinguishing D- and L-Aspartic and Isoaspartic Acids in Amyloid ß Peptides with Ultrahigh Resolution Ion Mobility Spectrometry." Chemical Communications 53, no. 56:7913-7916. PNNL-SA-124064. doi:10.1039/C7CC03321D
  • Zheng X., R. Wojcik, X. Zhang, Y.M. Ibrahim, K.E. Burnum-Johnson, D.J. Orton, and M.E. Monroe, et al. 2017. "Coupling Front-end Separations, Ion Mobility Spectrometry, and Mass Spectrometry for Enhanced Multidimensional Biological and Environmental Analyses." Annual Review of Analytical Chemistry 10. PNNL-SA-121198. doi:10.1146/annurev-anchem-061516-045212
  • Zheng X., R.S. Renslow, M.M. Makola, I.K. Webb, L. Deng, D.G. Thomas, and N. Govind, et al. 2017. "Structural Elucidation of cis/trans Dicaffeoylquinic Acid Photoisomerization Using Ion Mobility Spectrometry-Mass Spectrometry." The Journal of Physical Chemistry Letters 8, no. 7:1381-1388. PNNL-SA-123119. doi:10.1021/acs.jpclett.6b03015

2016

  • Burnum-Johnson K.E., S. Nie, C.P. Casey, M.E. Monroe, D.J. Orton, Y.M. Ibrahim, and M.A. Gritsenko, et al. 2016. "Simultaneous Proteomic Discovery and Targeted Monitoring using Liquid Chromatography, Ion Mobility Spectrometry and Mass Spectrometry." Molecular and Cellular Proteomics 15, no. 12:3694-3705. PNNL-SA-118308. doi:10.1074/mcp.M116.061143
  • Chen T., Y.M. Ibrahim, I.K. Webb, V. Garimella, X. Zhang, A.M. Hamid, and L. Deng, et al. 2016. "Mobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations." Analytical Chemistry 88, no. 3:1728-1733. PNNL-SA-113681. doi:10.1021/acs.analchem.5b03910
  • Deng L., Y.M. Ibrahim, A.M. Hamid, V. Garimella, I.K. Webb, X. Zheng, and S.A. Prost, et al. 2016. "Ultra-High Resolution Ion Mobility Separations Utilizing Traveling Waves in a 13-m Serpentine Path Length Structures for Lossless Ion Manipulations Module." Analytical Chemistry 88, no. 18:8957-8964. PNNL-SA-118270. doi:10.1021/acs.analchem.6b01915
  • Deng L., Y.M. Ibrahim, E.S. Baker, N.A. Aly, A.M. Hamid, X. Zhang, and X. Zheng, et al. 2016. "Ion Mobility Separations of Isomers based upon Long Path Length Structures for Lossless Ion Manipulations Combined with Mass Spectrometry." ChemistrySelect 1, no. 10:2396-2399. PNNL-SA-116187. doi:10.1002/slct.201600460
  • Deng L., Y.M. Ibrahim, V. Garimella, I.K. Webb, A.M. Hamid, R.V. Norheim, and S.A. Prost, et al. 2016. "Greatly Increasing Trapped Ion Populations for Mobility Separations Using Traveling Waves in Structures for Lossless Ion Manipulations." Analytical Chemistry 88, no. 20:10143-10150. PNNL-SA-119618. doi:10.1021/acs.analchem.6b02678
  • Garimella V., A.M. Hamid, L. Deng, Y.M. Ibrahim, I.K. Webb, E.M. Baker, and S.A. Prost, et al. 2016. "Squeezing of Ion Populations and Peaks in Traveling Wave Ion Mobility Separations and Structures for Lossless Ion Manipulations using Compression Ratio Ion Mobility Programming." Analytical Chemistry 88, no. 23:11877-11885. PNNL-SA-121131. doi:10.1021/acs.analchem.6b03660
  • Garimella V., Y.M. Ibrahim, K. Tang, I.K. Webb, E.M. Baker, A.V. Tolmachev, and T. Chen, et al. 2016. "Spatial Ion Peak Compression and its Utility in Ion Mobility Spectrometry." Journal of the American Society for Mass Spectrometry 27, no. 6:1128-1135. PNNL-SA-114168. doi:10.1007/s13361-016-1371-7
  • Hamid A.M., V. Garimella, Y.M. Ibrahim, L. Deng, X. Zheng, I.K. Webb, and G.A. Anderson, et al. 2016. "Achieving high resolution ion mobility separations using traveling waves in compact multi-turn Structures for Lossless Ion Manipulations modules." Analytical Chemistry 88, no. 18:8949-8956. PNNL-SA-118269. doi:10.1021/acs.analchem.6b01914
  • Ibrahim Y.M., V. Garimella, S.A. Prost, R. Wojcik, R.V. Norheim, E.M. Baker, and I. Rusyn, et al. 2016. "Development of an Ion Mobility Spectrometry-Orbitrap Mass Spectrometer Platform." Analytical Chemistry 88, no. 24:12152-12160. PNNL-SA-123568. doi:10.1021/acs.analchem.6b03027
  • Kyle J.E., X. Zhang, K.K. Weitz, M.E. Monroe, Y.M. Ibrahim, R.J. Moore, and J. Cha, et al. 2016. "Uncovering Biologically Significant Lipid Isomers with Liquid Chromatography, Ion Mobility Spectrometry and Mass Spectrometry." Analyst 141, no. 5:1649-1659. PNNL-SA-111991. doi:10.1039/C5AN02062J
  • Webb I.K., V. Garimella, R.V. Norheim, E.S. Baker, Y.M. Ibrahim, and R.D. Smith. 2016. "A Structures for Lossless Ion Manipulations (SLIM) Module for Collision Induced Dissociation." Journal of the American Society for Mass Spectrometry 27, no. 7:1285-1288. PNNL-SA-115654. doi:10.1007/s13361-016-1397-x
  • Zhang X., M.V. Romm, X. Zheng, E.M. Zink, Y. Kim, K.E. Burnum-Johnson, and D.J. Orton, et al. 2016. "SPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in bio?uids." Clinical Mass Spectrometry 2. PNNL-SA-117436. doi:10.1016/j.clinms.2016.11.002

2015

  • Baker E.S., K.E. Burnum-Johnson, Y.M. Ibrahim, D.J. Orton, M.E. Monroe, R.T. Kelly, and R.J. Moore, et al. 2015. "Enhancing Bottom-up and Top-down Proteomic Measurements with Ion Mobility Separations." Proteomics 15, no. 16:2766-2776. PNNL-SA-107785. doi:10.1002/pmic.201500048
  • Chen T., I.K. Webb, S.A. Prost, M.B. Harrer, R.V. Norheim, K. Tang, and Y.M. Ibrahim, et al. 2015. "Rectangular Ion Funnel: A New Ion Funnel Interface for Structures for Lossless Ion Manipulations." Analytical Chemistry 87, no. 1:716-722. PNNL-SA-105304. doi:10.1021/ac503564c
  • Chen T., T.L. Fillmore, S.A. Prost, R.J. Moore, Y.M. Ibrahim, and R.D. Smith. 2015. "Orthogonal Injection Ion Funnel Interface Providing Enhanced Performance for Selected Reaction Monitoring-Triple Quadruple Mass Spectrometry." Analytical Chemistry 87, no. 14:7326-7331. PNNL-SA-109430. doi:10.1021/acs.analchem.5b01482
  • Chen Y., F.E. Leach, N.K. Kaiser, X. Dang, Y.M. Ibrahim, R.V. Norheim, and G.A. Anderson, et al. 2015. "Improved ion optics for introduction of ions into a 9.4-T Fourier transform ion cyclotron resonance mass spectrometer." Journal of Mass Spectrometry 50, no. 1:280-284. PNNL-SA-104452. doi:10.1002/jms.3523
  • Garimella V., Y.M. Ibrahim, I.K. Webb, A.B. Ipsen, T. Chen, A.V. Tolmachev, and E.S. Baker, et al. 2015. "ION MANIPULATIONS IN STRUCTURES FOR LOSSLESS ION MANIPULATIONS (SLIM): COMPUTATIONAL EVALUATION OF A 90o TURN AND A SWITCH." Analyst 140, no. 20:6845-6852. PNNL-SA-107773. doi:10.1039/c5an00844a
  • Gunaratne K.D., V. Prabhakaran, Y.M. Ibrahim, R.V. Norheim, G.E. Johnson, and J. Laskin. 2015. "Design and Performance of a High-Flux Electrospray Ionization Source for Ion Soft-Landing." Analyst 140, no. 9:2957-2963. PNNL-SA-108077. doi:10.1039/C5AN00220F
  • Hamid A.M., Y.M. Ibrahim, V. Garimella, I.K. Webb, L. Deng, T. Chen, and G.A. Anderson, et al. 2015. "Characterization of Traveling Wave Ion Mobility Separations in Structures for Lossless Ion Manipulations." Analytical Chemistry 87, no. 22:11301-11308. PNNL-SA-111147. doi:10.1021/acs.analchem.5b02481
  • Ibrahim Y.M., E.M. Baker, W.F. Danielson, R.V. Norheim, D.C. Prior, G.A. Anderson, and M.E. Belov, et al. 2015. "Development of a New Ion Mobility Time-of-Flight Mass Spectrometer." International Journal of Mass Spectrometry 377. PNNL-SA-119651. doi:10.1016/j.ijms.2014.07.034
  • Ibrahim Y.M., E.S. Baker, W.F. Danielson, R.V. Norheim, D.C. Prior, G.A. Anderson, and M.E. Belov, et al. 2015. "Development of a New Ion Mobility (Quadrupole) Time-of-Flight Mass Spectrometer." International Journal of Mass Spectrometry 377. PNNL-SA-102133. doi:10.1016/j.ijms.2014.07.034
  • Zhang X., V. Garimella, S.A. Prost, I.K. Webb, T. Chen, K. Tang, and A.V. Tolmachev, et al. 2015. "Ion Trapping, Storage, and Ejection in Structures for Lossless Ion Manipulations." Analytical Chemistry 87, no. 12:6010-6016. PNNL-SA-107651. doi:10.1021/acs.analchem.5b00214
  • Zhang X., Y.M. Ibrahim, T. Chen, J.E. Kyle, R.V. Norheim, M.E. Monroe, and R.D. Smith, et al. 2015. "Enhancing Biological Analyses with Three Dimensional Field Asymmetric Ion Mobility, Low Field Drift Time Ion Mobility and Mass Spectrometry (µFAIMS/IMS-MS) Separations." Analyst 140. PNNL-SA-110080. doi:10.1039/c5an00897b

2014

  • Baker E.S., K.E. Burnum-Johnson, J.M. Jacobs, D.L. Diamond, R.N. Brown, Y.M. Ibrahim, and D.J. Orton, et al. 2014. "Advancing the High Throughput Identification of Liver Fibrosis Protein Signatures Using Multiplexed Ion Mobility Spectrometry." Molecular and Cellular Proteomics 13, no. 4:1119-1127. PNNL-SA-90826. doi:10.1074/mcp.M113.034595
  • Garimella V., Y.M. Ibrahim, I.K. Webb, A.V. Tolmachev, X. Zhang, S.A. Prost, and G.A. Anderson, et al. 2014. "Simulation of Electric Potentials and Ion Motion in Planar Electrode Structures for Lossless Ion Manipulations (SLIM)." Journal of the American Society for Mass Spectrometry 25, no. 11:1890-1896. PNNL-SA-103104. doi:10.1007/s13361-014-0976-y
  • Ibrahim Y.M., V. Garimella, A.V. Tolmachev, E.S. Baker, and R.D. Smith. 2014. "Improving Ion Mobility Measurement Sensitivity by Utilizing Helium in an Ion Funnel-Trap." Analytical Chemistry 86, no. 11:5295-5299. PNNL-SA-100190. doi:10.1021/ac404250z
  • Prost S.A., K.L. Crowell, E.S. Baker, Y.M. Ibrahim, B.H. Clowers, M.E. Monroe, and G.A. Anderson, et al. 2014. "Detecting and Removing Data Artifacts in Hadamard Transform Ion Mobility-Mass Spectrometry Measurements." Journal of the American Society for Mass Spectrometry 25, no. 12:2020-2027. PNNL-SA-100086. doi:10.1007/s13361-014-0895-y
  • Shvartsburg A.A., Y.M. Ibrahim, and R.D. Smith. 2014. "Differential Ion Mobility Separations in up to 100% Helium Using Microchips." Journal of the American Society for Mass Spectrometry 25, no. 3:480-489. PNNL-SA-97871. doi:10.1007/s13361-013-0797-4
  • Tolmachev A.V., I.K. Webb, Y.M. Ibrahim, V. Garimella, X. Zhang, G.A. Anderson, and R.D. Smith. 2014. "Characterization of Ion Dynamics in Structures for Lossless Ion Manipulations." Analytical Chemistry 86, no. 18:9162-9168. PNNL-SA-103154. doi:10.1021/ac502054p
  • Webb I.K., T. Chen, W.F. Danielson, Y.M. Ibrahim, K. Tang, G.A. Anderson, and R.D. Smith. 2014. "Implementation of Dipolar Resonant Excitation Collision Induced Dissociation with Ion Mobility/Time-of-Flight MS." Journal of the American Society for Mass Spectrometry 25, no. 4:563-571. PNNL-SA-98909. doi:10.1007/s13361-013-0815-6
  • Webb I.K., V. Garimella, A.V. Tolmachev, T. Chen, X. Zhang, J.T. Cox, and R.V. Norheim, et al. 2014. "Mobility-Resolved Ion Selection in Uniform Drift Field Ion Mobility Spectrometry/Mass Spectrometry; Dynamic Switching in Structures for Lossless Ion Manipulations." Analytical Chemistry 86, no. 19:9632-9637. PNNL-SA-103347. doi:10.1021/ac502139e
  • Webb I.K., V. Garimella, A.V. Tolmachev, T. Chen, X. Zhang, R.V. Norheim, and S.A. Prost, et al. 2014. "Experimental Evaluation and Optimization of Structures for Lossless Ion Manipulations for Ion Mobility Spectrometry with Time-of-Flight Mass Spectrometry." Analytical Chemistry 86, no. 18:9169-9176. PNNL-SA-103224. doi:10.1021/ac502055e

2013

  • Crowell K.L., E.S. Baker, S.H. Payne, Y.M. Ibrahim, M.E. Monroe, G.W. Slysz, and B.L. Lamarche, et al. 2013. "Increasing Confidence of LC-MS Identifications by Utilizing Ion Mobility Spectrometry." International Journal of Mass Spectrometry 354-355. PNNL-SA-95461. doi:10.1016/j.ijms.2013.06.028
  • Crowell K.L., G.W. Slysz, E.S. Baker, B.L. Lamarche, M.E. Monroe, Y.M. Ibrahim, and S.H. Payne, et al. 2013. "LC-IMS-MS Feature Finder: Detecting Multidimensional Liquid Chromatography, Ion Mobility, and Mass Spectrometry Features in Complex Datasets." Bioinformatics 29, no. 21:2804-2805. PNNL-SA-95214. doi:10.1093/bioinformatics/btt465
  • Merkley E.D., E.S. Baker, K.L. Crowell, D.J. Orton, T. Taverner, C. Ansong, and Y.M. Ibrahim, et al. 2013. "Mixed-Isotope Labeling with LC-IMS-MS for Characterization of Protein-Protein Interactions by Chemical Cross-Linking." Journal of the American Society for Mass Spectrometry 24, no. 3:444-449. PNNL-SA-88464. doi:10.1007/s13361-012-0565-x

2012

  • Baker E.S., T. Liu, V.A. Petyuk, K.E. Burnum-Johnson, Y.M. Ibrahim, G.A. Anderson, and R.D. Smith. 2012. "Mass Spectrometry for Translational Proteomics: Progress and Clinical Implications." Genome Medicine 4. PNNL-SA-86783. doi:10.1186/gm364
  • Burnum K.E., Y. Hirota, E.S. Baker, M. Yoshie, Y.M. Ibrahim, M.E. Monroe, and G.A. Anderson, et al. 2012. "Uterine deletion of Trp53 compromises antioxidant responses in mouse decidua." Endocrinology 153, no. 9:4568-4579. PNNL-SA-87211. doi:10.1210/en.2012-1335

2011

  • Belov M.E., R.T. Kurulugama, D. Lopez-Ferrer, Y.M. Ibrahim, and E.S. Baker. 2011. "New Developments in LC-MS and Other Hyphenated Techniques." In Sample Preparation in Biological Mass Spectrometry, edited by AR Ivanov & AV Lazarev. 981-1030. New York, New York:Springer. PNNL-SA-74555.
  • Belov M.E., S. Prasad, D.C. Prior, W.F. Danielson, K.K. Weitz, Y.M. Ibrahim, and R.D. Smith. 2011. "Pulsed Multiple Reaction Monitoring Approach to Enhancing Sensitivity of a Tandem Quadrupole Mass Spectrometer." Analytical Chemistry 83, no. 6:2162-2171. PNNL-SA-74498. doi:10.1021/ac103006b
  • Ibrahim Y.M., A.A. Shvartsburg, R.D. Smith, and M.E. Belov. 2011. "Ultrasensitive Identification of Localization Variants of Modified Peptides Using Ion Mobility Spectrometry." Analytical Chemistry 83, no. 14:5617 - 5623. PNNL-SA-78723. doi:10.1021/ac200719n

2010

  • Baker E.S., E.A. Livesay, D.J. Orton, R.J. Moore, W.F. Danielson, D.C. Prior, and Y.M. Ibrahim, et al. 2010. "An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput Proteomic Studies." Journal of Proteome Research 9, no. 2:997-1006. PNNL-SA-67461. doi:10.1021/pr900888b
  • Belov M.E., Y.M. Ibrahim, and R.D. Smith. 2010. "Ion Accumulation Approaches for Increasing Sensitivity and Dynamic Range in the Analysis of Complex Samples." In Practical Aspects of Trapped Ion Mass Spectrometry: Theory and Instrumentation, edited by RE March and JFJ Todd. 401-432. Boca Raton, Florida:CRC Press. PNNL-SA-60908.
  • Ibrahim Y.M., D.C. Prior, E.S. Baker, R.D. Smith, and M.E. Belov. 2010. "Characterization of an Ion Mobility-Multiplexed Collision Induced Dissociation- Tandem Time-of-Flight Mass Spectrometry Approach." International Journal of Mass Spectrometry 293, no. 1-3:34-44. PNNL-SA-68112.
  • Shah A.R., K. Agarwal, E.S. Baker, M. Singhal, A.M. Mayampurath, Y.M. Ibrahim, and L.J. Kangas, et al. 2010. "Machine learning based prediction for peptide drift times in ion mobility spectrometry." Bioinformatics 26, no. 13:1601-1607. PNWD-SA-8802. doi:10.1093/bioinformatics/btq245

2008

  • Clowers B.H., M.E. Belov, D.C. Prior, W.F. Danielson, Y.M. Ibrahim, and R.D. Smith. 2008. "Pseudorandom Sequence Modifications for Ion Mobility Orthogonal Time-of-Flight Mass Spectrometry." Analytical Chemistry 80, no. 7:2464-2473. PNWD-SA-7989. doi:10.1021/ac7022712
  • Clowers B.H., Y.M. Ibrahim, D.C. Prior, W.F. Danielson, M.E. Belov, and R.D. Smith. 2008. "Enhanced Ion Utilization Efficiency Using an Electrodynamic Ion Funnel Trap as an Injection Mechanism for Ion Mobility Spectrometry." Analytical Chemistry 80, no. 3:612-623. PNWD-SA-7885. doi:10.1021/ac701648p
  • Ibrahim Y.M., M.E. Belov, A.V. Liyu, and R.D. Smith. 2008. "Automated Gain Control Ion Funnel Trap for Orthogonal Time-of-Flight Mass Spectrometry." Analytical Chemistry 80, no. 14:5367-5376. PNNL-SA-59266. doi:10.1021/ac8003488

2007

  • Ibrahim Y.M., M.E. Belov, A.V. Tolmachev, D.C. Prior, and R.D. Smith. 2007. "Ion Funnel Trap Interface for Orthogonal Time-of-Flight Mass Spectrometry." Analytical Chemistry 79, no. 20:7845-7852. PNNL-SA-54591. doi:10.1021/ac071091m

2006

  • Ibrahim Y.M., K. Tang, A.V. Tolmachev, A.A. Shvartsburg, and R.D. Smith. 2006. "Improving Mass Spectrometer Sensitivity Using a High-Pressure Electrodynamic Ion Funnel Interface." Journal of the American Society for Mass Spectrometry 17, no. 9:1299-1305. PNNL-SA-49272. doi:10.1016/j.jasms.2006.06.005