Vivian Lin
Chemist
Vivian Lin
Chemist
Biography
Vivian Lin earned her PhD in organic chemistry from the University of California, Berkeley with Professor Chris Chang, developing fluorescent probes for imaging redox active small molecules. Afterward, she traveled to Switzerland for a postdoctoral fellowship in the laboratory of Professor Kris McNeill at ETH Zürich, studying the photochemical reactivity of organic matter in aquatic systems. Lin joined the Chemical Biology team at PNNL as a postdoctoral research associate in 2017 and is now a staff scientist focused on the development and application of chemical biology tools to a variety of biological systems related to human health and the environment.
Disciplines and Skills
- Organic Synthesis
- Chemical Biology
Education
- PhD in Chemistry, University of California, Berkeley
- BA in Biology and Chemistry, Scripps College
Affiliations and Professional Service
- Operational Excellence Award, Environmental and Biological Sciences Directorate, PNNL
- Fulbright U.S. Student Program Fellowship
- Amgen Graduate Fellowship in Organic Chemistry
Publications
2024
- Hollerbach A.L., V.S. Lin, Y.M. Ibrahim, R.G. Ewing, T.O. Metz, and K.E. Rodda. 2024. "Elucidating the Gas-Phase Behavior of Nitazene Analog Protomers using Structures for Lossless Ion Manipulations Ion Mobility-Orbitrap Mass Spectrometry." Journal of the American Society for Mass Spectrometry 35, no. 7:1609-1621. PNNL-SA-198305. doi:10.1021/jasms.4c00200
- Hollerbach A.L., Y.M. Ibrahim, V.S. Lin, K.J. Schultz, A.P. Huntley, P.B. Armentrout, and T.O. Metz, et al. 2024. "Identification of Unique Fragmentation Patterns of Fentanyl Analog Protomers using Structures for Lossless Ion Manipulations Ion Mobility-Orbitrap Mass Spectrometry." Journal of the American Society for Mass Spectrometry 35, no. 4:793-803. PNNL-SA-192943. doi:10.1021/jasms.4c00049
- Powell S.M., D. Herrera, I.V. El Khoury, C.M. Perdue, N.C. Sadler, J.R. Cort, and G.O. Robinson, et al. 2024. Accelerating the identification of novel secondary metabolites in bioenergy plant root exudates using MicroED. PNNL-36689. Richland, WA: Pacific Northwest National Laboratory. Accelerating the identification of novel secondary metabolites in bioenergy plant root exudates using MicroED
- Schultz K.J., J.H. Nguyen, V.S. Lin, C. Kombala Nanayakkara Thambiliya, K.J. Tyrrell, and P.M. Lalli. 2024. Heracles: Predictive Tools for Opioid Crisis Intervention - m/q Initiative Project Report. PNNL-36739. Richland, WA: Pacific Northwest National Laboratory. Heracles: Predictive Tools for Opioid Crisis Intervention - m/q Initiative Project Report
2023
- Zegeye E., V.S. Lin, J. Nunez, N.A. Sconzo, S.O. Purvine, A.T. Wright, and J.J. Moran. 2023. "Enzymatically hydrolyzed fluorescence-based chemical probe enables in situ mapping of chitinase activity in the rhizosphere." Soil Biology and Biochemistry 184. PNNL-SA-182442. doi:10.1016/j.soilbio.2023.109122
- Zemaitis K., V.S. Lin, A. Ahkami, T.E. Winkler, C.R. Anderton, and D. Velickovic. 2023. "Expanded Coverage of Phytocompounds by Mass Spectrometry Imaging Using On-Tissue Chemical Derivatization by 4-APEBA." Analytical Chemistry 95, no. 35:12701-12709. PNNL-SA-179568. doi:10.1021/acs.analchem.3c01345
2022
- Lin V.S., N.C. Sadler, P. Handakumbura, K.L. Tate, G.X. Lomas, and J. Ramirez. 2022. Characterizing proteases in sorghum drought response using activity-based protein profiling (ABPP). PNNL-33427. Richland, WA: Pacific Northwest National Laboratory. Characterizing proteases in sorghum drought response using activity-based protein profiling (ABPP)
2021
- Lin V.S. 2021. "Interrogating Plant-Microbe Interactions with Chemical Tools: Click Chemistry Reagents for Metabolic Labeling and Activity-Based Probes." Molecules 26, no. 1:Article No.243. PNNL-SA-158989. doi:10.3390/molecules26010243
- Schultz K.J., S.M. Colby, V.S. Lin, A.T. Wright, and R.S. Renslow. 2021. "Ligand- and Structure-Based Analysis of Deep Learning-Generated Potential alpha2a Adrenoceptor Agonists." Journal of Chemical Information and Modeling 61, no. 1:481-492. PNNL-SA-155859. doi:10.1021/acs.jcim.0c01019
2020
- Lin V.S., J.J. Rosnow, M.Y. McGrady, D.N. Smercina, J. Nunez, R.S. Renslow, and J.J. Moran. 2020. "Non-destructive spatial analysis of phosphatase activity and total protein distribution in the rhizosphere using a root blotting method." Soil Biology and Biochemistry 146. PNNL-SA-149591. doi:10.1016/j.soilbio.2020.107820
- Lin V.S., N.C. Sadler, and Y. Farris. 2020. Probing Cooperation and Competition between Paenibacillus polymyxa and Setaria viridis under Nutrient Stress. PNNL-30598. Richland, WA: Pacific Northwest National Laboratory. Probing Cooperation and Competition between Paenibacillus polymyxa and Setaria viridis under Nutrient Stress
- Velickovic D., V.S. Lin, A. Rivas-Ubach, C.R. Anderton, and J.J. Moran. 2020. "An approach for broad molecular imaging of the root-soil interface via indirect matrix-assisted laser desorption/ionization mass spectrometry." Soil Biology and Biochemistry 146. PNNL-SA-150080. doi:10.1016/j.soilbio.2020.107804
2019
- Lin V.S., N.C. Sadler, Y. Farris, E.H. Denis, L.C. Webber, and R.M. Francis. 2019. Identification of plant host and microbe model system for study of rhizophagy cycle. PNNL-29249. Richland, WA: Pacific Northwest National Laboratory. Identification of plant host and microbe model system for study of rhizophagy cycle