Chemist
Chemist

Biography

Tracy Baker is an organic synthetic chemist in the Materials Sciences group of the Physical Sciences Division (PSD) at Pacific Northwest National Laboratory (PNNL). She is the team leader of the Nucleation and Growth team at PNNL and serves as the limited-term researcher liaison for the PSD. Baker previously worked as a research scientist for Neurocrine Biosciences, Inc, and contributed to the discovery and development of new drugs through the synthesis of biomimetic small molecules. Previously, she was a postdoctoral National Institutes of Health Research Fellow in the laboratory of Dr. Murray Goodman focusing on peptide chemistry and the development of a guanidinylation methodology of amines including aminoglycosides. For her graduate research, she developed expertise in the fields of phosphonate, nucleoside, and carbohydrate chemistry.

Disciplines and Skills

  • Characterization
  • Infrared
  • Purification
  • Synthetic organic chemistry
  • Team management
  • UV/Vis spectroscopy

Education

  • PhD in chemistry, University of Iowa
  • BS in biology, Illinois State University
  • BS in chemistry, Illinois State University

Publications

2024

  • Schneider, M. D., T. J. Baker, N. K. Scharko, T. A. Blake, R. G. Tonkyn, B. M. Forland, and T. J. Johnson. 2024. "A Method for Generating Quantitative Vapor-Phase Infrared Spectra of Solids: Results for Phenol, Camphor, Menthol, Syringol, Dicyclopentadiene and Naphthalene." Journal of Quantitative Spectroscopy and Radiative Transfer 323. PNNL-SA-195515. doi:10.1016/j.jqsrt.2024.109045

2023

  • Baker, T. J., R. G. Tonkyn, C. J. Thompson, M. K. Dunlap, P. Koster Van Groos, N. A. Thakur, M. J. Wilhelm, et al. 2023. "An infrared spectral database for gas-phase quantitation of volatile per- and polyfluoroalkyl substances (PFAS)." Journal of Quantitative Spectroscopy and Radiative Transfer 295. PNNL-SA-177601. doi:10.1016/j.jqsrt.2022.108420
  • Bays, J. T., T. J. Baker, D. Barpaga, K. B. Campbell, G. W. Coffey, M. A. Fuller, J. C. Linehan, et al. 2023. Oxygenate Onboard Separation for Octane-on-Demand. PNNL-35404. Richland, WA: Pacific Northwest National Laboratory.  doi:10.2172/2332884

2022

  • Johnson, T. J., T. J. Baker, A. M. Bradley, M. O. Yokosuk, and T. L. Myers. 2022. "Twice-modulated light in Fourier Transform Infrared (FT-IR) spectrometers from reflective sample: Avoiding distorted intensity values." Applied Spectroscopy 76 (5): 620–624. PNNL-SA-167655. doi:10.1177/00037028211066336

2021

  • Cosimbescu, L., K. B. Campbell, T. J. Baker, M. S. Swita, and D. J. Gaspar. 2021. "The Quest for Efficient Oxygenated Fuels: Examining Interactions Between Lubricant Components and Oxygenates." Fuel 288. PNNL-SA-155100. doi:10.1016/j.fuel.2020.119728

2005

  • Manley, J. M., T. J. Roper, T. D. Lash. 2005. “Synthesis of Isomeric Angularly Annealed Dinaphthoporphyrin Systems: Examination of the Relative Positioning and Orientation of Ring Fusion as Factors Influencing the Porphyrin Chromophore.” J. Org. Chem. 70 (3): 874–891. doi:10.1021/jo040269r

2000

  • Baker, T. J., N. W. Luedtke, Y. Tor, M. Goodman. 2000. “Synthesis and Anti-HIV Activity of Guanidinoglycosides.” J. Org. Chem. 65 (26): 9054–9058., doi:10.1021/jo001142e
  • Baker, T. J., Y. Rew, M. Goodman. 2000. “Novel reagents and reactions for drug design.” Pure Appl. Chem. 72 (3): 347–354. doi:10.1351/pac200072030347
  • Baker, T. J. and D. F. Wiemer. 2000. “Synthesis and Rearrangement of 3′-α-Diethylphosphono-3′-β-O-methanesulfonyluridines.” Tetrahedron 56 (20): 3127–3131. doi:10.1016/S0040-4020(00)00198-8
  • Luedtke, N. W., T. J. Baker, M. Goodman, and Y. Tor. 2000. “Guanidinoglycosides:  A Novel Family of RNA Ligands.” J. Am. Chem. Soc. 122 (48): 12035–12036. doi:10.1021/ja002421m
  • Nakamura, K., T. J. Baker, and M. Goodman. 2000. “Total Synthesis of Monatin.” Org. Lett. 2 (19): 2967–2970. doi:10.1021/ol006246q

1999

  • Lee, J. H., T. J. Baker, L. K. Mahal, J. Zabner, C. R. Bertozzi, D. F. Wiemer, and M. J. Welsh. 1999. “Engineering Novel Cell Surface Receptors for Virus-mediated Gene Transfer.”Nucleic Acids, Protein Synthesis, and Molecular Genetics 274 (31): 21878–21884. doi:10.1074/jbc.274.31.21878

1998

  • Baker, T. J. and D. F. Wiemer. 1998. “Regiospecific Vinyl Phosphate/β-Keto Phosphonate Rearrangements Initiated by Halogen−Metal Exchange.” J. Org. Chem. 1998 63 (8): 2613–2618. doi:10.1021/jo972131x
  • Feichtinger, K., H. L. Sings, T. J. Baker, K. Matthews, and M. Goodman. 1998. “Triurethane-Protected Guanidines and Triflyldiurethane-Protected Guanidines: New Reagents for Guanidinylation Reactions.” J. Org. Chem. 1998 63 (23): 8432–8439. doi:10.1021/jo9814344

1994

  • Lash, T. D. and T. J. Roper. 1994. “Synthesis of dinaphthoporphyrins from dihydronaphtho[1,2-c]pyrroles.” Tetrahedron Letters 35 (42): 7715–7718. doi:10.1016/0040-4039(94)80100-2