Biosample Pipeline Team Lead, Mass Spectrometry Operations Lead
Biosample Pipeline Team Lead, Mass Spectrometry Operations Lead


Ron Moore has over 30 years of experience in the operation, maintenance, and repair of a wide variety of Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) instrumentation. Following college, he spent the next 11 years in a toxicology research facility at PNNL, learning disciplined research methods while working under Federal Drug Administration regulations for good laboratory practice for nonclinical laboratory studies. One core job function was customization and implementation of fully automated GC systems used for test agent monitoring inside animal chambers. He also led bioanalytical methods development, validation, and implementation for quantification of chemicals and metabolites in a wide variety of biological matrices. During this time, he gained substantial experience on GC-MS, LC-MS, Inductively Coupled Plasma-Mass Spectrometry, and Liquid Scintillation instruments.

Proteomics suite - EMSL

For the last 20 years, Moore has worked in the production omics MS capability located in the Environmental Molecular Sciences Laboratory, which currently consists of over 35 systems and includes Orbitrap, triple-quad, Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry, Ion Mobility Mass Spectrometry-Time of Flight, and GC-MS instruments. He has also largely managed the day-to-day operations of this capability and has been involved with or led many projects where automation was used to improve sample throughput and reproducibility. Moore also has been involved in several projects aimed at developing more rugged and sensitive electrospray ionization sources for improved ion transmission to the MS detector.

Disciplines and Skills

  • Analytical method validation
  • Analytical methods development
  • Automation
  • Gas chromatography
  • Instrument interfacing
  • LC-MS
  • MS
  • Project management
  • Proteomics


  • BS in Biology, minor in Chemistry, Washington State University, 1989
  • Project Management Professional Certification, Project Management Institute, 2019

Awards and Recognitions

  • R&D 100 Magazine Award Finalist for NanoPOTS Technology, 2018
  • R&D 100 Magazine Award for Combined Orthogonal Mobility and Mass Evaluation Technology, 2013
  • Top 10 most prolific authors listed in Journal of Proteomics Research (tenth anniversary edition), 2011



  • Dou Y., E. Kawaler, D.C. Zhou, M.A. Gritsenko, C. Huang, L. Blumenberg, and A. Karpova, et al. 2020. "Proteogenomic Characterization of Endometrial Carcinoma." Cell 180, no. 4:729-748.e26. PNNL-SA-147326. doi:10.1016/j.cell.2020.01.026
  • McDermott J.E., O.A. Arshad, V.A. Petyuk, Y. Fu, M.A. Gritsenko, T.R. Clauss, and R.J. Moore, et al. 2020. "Proteogenomic characterization of ovarian HGSC implicates mitotic kinases, replication stress in observed chromosomal instability." Cell Reports Medicine 1, no. 1:Article No. 100004. PNNL-SA-145681. doi:10.1016/j.xcrm.2020.100004
  • Piehowski P.D., Y. Zhu, L.M. Bramer, K.G. Stratton, R. Zhao, D.J. Orton, and R.J. Moore, et al. 2020. "Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-µm spatial resolution." Nature Communications 11, no. 1:Article No. 8. PNNL-SA-138884. doi:10.1038/s41467-019-13858-z
  • Tsai C., R. Zhao, S.M. Williams, R.J. Moore, K.D. Schultz, W.B. Chrisler, and L. Pasa Tolic, et al. 2020. "An Improved Boosting to Amplify Signal with Isobaric Labeling (iBASIL) Strategy for Precise Quantitative Single-cell Proteomics." Molecular and Cellular Proteomics 19, no. 5:828-838. PNNL-SA-149183. doi:10.1074/mcp.RA119.001857
  • Zhang T., M.J. Gaffrey, D.G. Thomas, T.J. Weber, B.M. Hess, K.K. Weitz, and P.D. Piehowski, et al. 2020. "A proteome-wide assessment of the oxidative stress paradigm for metal and metal-oxide nanomaterials in human macrophages." NanoImpact 17. PNNL-SA-147217. doi:10.1016/j.impact.2019.100194
  • Zhang T., M.J. Gaffrey, M.E. Monroe, D.G. Thomas, K.K. Weitz, P.D. Piehowski, and V.A. Petyuk, et al. 2020. "Block design with common reference samples enables robust large-scale label-free quantitative proteome profiling." Journal of Proteome Research 19, no. 7:2863-2872. PNNL-SA-151164. doi:10.1021/acs.jproteome.0c00310
  • Zhou M., N.O. Uwugiaren, S.M. Williams, R.J. Moore, R. Zhao, D. Goodlett, and I. Dapic, et al. 2020. "Sensitive Top-Down Proteomics Analysis of Low Number of Mammalian Cells Using a Nanodroplet Sample Processing Platform." Analytical Chemistry 92, no. 10:7087-7095. PNNL-SA-149823.


  • Campbell M.D., J. Duan, A.T. Samuelson, M.J. Gaffrey, G.E. Merrihew, J.D. Egertson, and L. Wang, et al. 2019. "Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice." Free Radical Biology & Medicine 134. PNNL-SA-140379. doi:10.1016/j.freeradbiomed.2018.12.031
  • Dou M., C. Tsai, P.D. Piehowski, Y. Wang, T.L. Fillmore, R. Zhao, and R.J. Moore, et al. 2019. "Automated Nanoflow Two-Dimensional Reversed-Phase Liquid Chromatography System Enables In-Depth Proteome and Phosphoproteome Profiling of Nanoscale Samples." Analytical Chemistry 91, no. 15:9707-9715. PNNL-SA-141437. doi:10.1021/acs.analchem.9b01248
  • Dou M., G. Clair, C. Tsai, K. Xu, W.B. Chrisler, R.L. Sontag, and R. Zhao, et al. 2019. "High-Throughput Single Cell Proteomics Enabled by Multiplex Isobaric Labelling in a Nanodroplet Sample Preparation Platform." Analytical Chemistry 91, no. 20:13119-13127. PNNL-SA-146297. doi:10.1021/acs.analchem.9b03349
  • Gibbons B.C., T.L. Fillmore, Y. Gao, R.J. Moore, T. Liu, E.S. Nakayasu, and T.O. Metz, et al. 2019. "Rapidly Assessing the Quality of Targeted Proteomics Experiments through Monitoring Stable-Isotope Labeled Standards." Journal of Proteome Research 18, no. 2:694-699. PNNL-SA-137457. doi:10.1021/acs.jproteome.8b00688
  • Tsai C., J.S. Smith, K. Krajewski, R. Zhao, A.M. Moghieb, C.D. Nicora, and X. Xiong, et al. 2019. "Tandem Mass Tag Labeling Facilitates Reversed-Phase Liquid Chromatography-Mass Spectrometry Analysis of Hydrophilic Phosphopeptides." Analytical Chemistry 91, no. 18:11606-11613. PNNL-SA-142808. doi:10.1021/acs.analchem.9b01814
  • Zolghadr A., J.J. Biernacki, and R.J. Moore. 2019. "Biomass Fast Pyrolysis Using a Novel Microparticle Microreactor Approach: Effect of Particles Size, Biomass Type, and Temperature." Energy and Fuels 33, no. 2:1146-1156. PNNL-SA-139365. doi:10.1021/acs.energyfuels.8b03395


  • Callister S.J., T.L. Fillmore, C.D. Nicora, J.B. Shaw, S.O. Purvine, D.J. Orton, and R.A. White, et al. 2018. "Addressing the challenge of soil metaproteome complexity by improving metaproteome depth of coverage Through two-dimensional liquid chromatography." Soil Biology and Biochemistry 125. PNNL-SA-131999. doi:10.1016/j.soilbio.2018.07.018
  • Gargano A., J.B. Shaw, M. Zhou, C.S. Wilkins, T.L. Fillmore, R.J. Moore, and G.W. Somsen, et al. 2018. "Increasing the Separation Capacity of Intact Histone Proteoforms Chromatography Coupling Online Weak Cation Exchange-HILIC to Reversed Phase LC UVPD-HRMS." Journal of Proteome Research 17, no. 11:3791-3800. PNNL-SA-138847. doi:10.1021/acs.jproteome.8b00458
  • Mertins P., L.C. Tang, K. Krug, D.J. Clark, M.A. Gritsenko, L. Chen, and K. Clauser, et al. 2018. "Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography-mass spectrometry." Nature Protocols 13, no. 7:1632-1661. PNNL-SA-137930. doi:10.1038/s41596-018-0006-9
  • Moghieb A.M., G. Clair, H.D. Mitchell, J. Kitzmiller, E.M. Zink, Y. Kim, and V.A. Petyuk, et al. 2018. "Time-resolved Proteome Profiling of Normal Lung Development." American Journal of Physiology-Lung Cellular and Molecular Physiology 315, no. 1:L11-L24. PNNL-SA-127218. doi:10.1152/ajplung.00316.2017
  • Orton D.J., M.M. Tfaily, R.J. Moore, B.L. Lamarche, X. Zheng, T.L. Fillmore, and R.K. Chu, et al. 2018. "A Customizable Flow Injection System for Automated, High Throughput and Time Sensitive Ion Mobility Spectrometry and Mass Spectrometry Measurements." Analytical Chemistry 90, no. 1:737-744. PNNL-SA-128111. doi:10.1021/acs.analchem.7b02986
  • Piehowski P.D., R. Zhao, R.J. Moore, G. Clair, and C.K. Ansong. 2018. "Quantitative Proteomic Analysis of Mass Limited Tissue Samples for Spatially Resolved Tissue Profiling." In Tissue Proteomics: Methods and Protocols, 2nd Edition. Methods in Molecular Biology, edited by MM Sarwal and TK Sigdel. 269-277. New York, New York:Humana Press. PNNL-SA-133218. doi:10.1007/7651_2017_78
  • Stanfill B.A., E.S. Nakayasu, L.M. Bramer, A.M. Thompson, C.K. Ansong, T. Clauss, and M.A. Gritsenko, et al. 2018. "Quality Control Analysis in Real-time (QC-ART): A Tool for Real-time Quality Control Assessment of Mass Spectrometry-based Proteomics Data." Molecular and Cellular Proteomics 17, no. 9:1824-1836. PNNL-SA-129934. doi:10.1074/mcp.RA118.000648
  • Zhu Y., G. Clair, W.B. Chrisler, Y. Shen, R. Zhao, A.K. Shukla, and R.J. Moore, et al. 2018. "Proteomic Analysis of Single Mammalian Cells Enabled by Microfluidic Nanodroplet Sample Preparation and Ultrasensitive NanoLC-MS." Angewandte Chemie International Edition 57, no. 38:12370-12374. PNNL-SA-132946. doi:10.1002/anie.201802843
  • Zhu Y., J. Podolak, R. Zhao, A.K. Shukla, R.J. Moore, G.V. Thomas, and R.T. Kelly. 2018. "Proteome Profiling of 1 to 5 Spiked Circulating Tumor Cells Isolated from Whole Blood Using Immunodensity Enrichment, Laser Capture Microdissection, Nanodroplet Sample Processing, and Ultrasensitive nanoLC-MS." Analytical Chemistry 90, no. 20:11756-11759. PNNL-SA-140551. doi:10.1021/acs.analchem.8b03268
  • Zhu Y., P.D. Piehowski, R. Zhao, J. Chen, Y. Shen, R.J. Moore, and A.K. Shukla, et al. 2018. "Nanodroplet processing platform for deep and quantitative proteome profiling of 10-100 mammalian cells." Nature Communications 9, no. 1:882. PNNL-SA-125235. doi:10.1038/s41467-018-03367-w
  • Zhu Y., R. Zhao, P.D. Piehowski, R.J. Moore, S. Lim, V.J. Orphan, and L. Pasa Tolic, et al. 2018. "Subnanogram proteomics: impact of LC column selection, MS instrumentation and data analysis strategy on proteome coverage for trace samples." International Journal of Mass Spectrometry 427. PNNL-SA-125645. doi:10.1016/j.ijms.2017.08.016


  • Kyle J.E., C.P. Casey, K.G. Stratton, E.M. Zink, Y. Kim, X. Zheng, and M.E. Monroe, et al. 2017. "Comparing Identified and Statistically Significant Lipids and Metabolites in 15-Year Old Serum and Dried Blood Spot Samples for Longitudinal Studies." Rapid Communications in Mass Spectrometry 31, no. 5:447-456. PNNL-SA-121197. doi:10.1002/rcm.7808
  • Liberton M.L., W.B. Chrisler, C.D. Nicora, R.J. Moore, R.D. Smith, D.W. Koppenaal, and H.B. Pakrasi, et al. 2017. "Phycobilisome Truncation Causes Widespread Proteome Changes in Synechocystis sp. PCC 6803." PLoS One 12, no. 3:e0173251. PNNL-SA-112677. doi:10.1371/journal.pone.0173251
  • Park J., P.D. Piehowski, C.S. Wilkins, M. Zhou, J.A. Mendoza, G.M. Fujimoto, and B.C. Gibbons, et al. 2017. "Informed-Proteomics: Open Source Software Package for Top-down Proteomics." Nature Methods 14, no. 9:909-914. PNNL-SA-120171. doi:10.1038/nmeth.4388
  • Raso A.R., K.D. Custard, N.W. May, D. Tanner, M.K. Newburn, L.R. Walker, and R.J. Moore, et al. 2017. "Active molecular iodine photochemistry in the Arctic." Proceedings of the National Academy of Sciences of the United States of America 114, no. 38:10053-10058. PNNL-SA-129703. doi:10.1073/pnas.1702803114
  • Zheng X., R. Wojcik, X. Zhang, Y.M. Ibrahim, K.E. Burnum-Johnson, D.J. Orton, and M.E. Monroe, et al. 2017. "Coupling Front-end Separations, Ion Mobility Spectrometry, and Mass Spectrometry for Enhanced Multidimensional Biological and Environmental Analyses." Annual Review of Analytical Chemistry 10. PNNL-SA-121198. doi:10.1146/annurev-anchem-061516-045212


  • Burnum-Johnson K.E., S. Nie, C.P. Casey, M.E. Monroe, D.J. Orton, Y.M. Ibrahim, and M.A. Gritsenko, et al. 2016. "Simultaneous Proteomic Discovery and Targeted Monitoring using Liquid Chromatography, Ion Mobility Spectrometry and Mass Spectrometry." Molecular and Cellular Proteomics 15, no. 12:3694-3705. PNNL-SA-118308. doi:10.1074/mcp.M116.061143
  • Clair G., P.D. Piehowski, T. Nicola, J. Kitzmiller, E.L. Huang, E.M. Zink, and R.L. Sontag, et al. 2016. "Spatially-Resolved Proteomics: Rapid Quantitative Analysis of Laser Capture Microdissected Alveolar Tissue Samples." Scientific Reports 6. PNNL-SA-119185. doi:10.1038/srep39223
  • Huang E.L., P.D. Piehowski, D.J. Orton, R.J. Moore, W. Qian, C.P. Casey, and X. Sun, et al. 2016. "SNaPP: Simplified Nano-Proteomics Platform for reproducible global proteomic analysis of nanogram protein quantities." Endocrinology 157, no. 3:1307-14. PNNL-SA-111854. doi:10.1210/en.2015-1821
  • Kyle J.E., X. Zhang, K.K. Weitz, M.E. Monroe, Y.M. Ibrahim, R.J. Moore, and J. Cha, et al. 2016. "Uncovering Biologically Significant Lipid Isomers with Liquid Chromatography, Ion Mobility Spectrometry and Mass Spectrometry." Analyst 141, no. 5:1649-1659. PNNL-SA-111991. doi:10.1039/C5AN02062J
  • White R.A., S.J. Callister, R.J. Moore, E.M. Baker, and J.K. Jansson. 2016. "The Past, Present and Future of Microbiome Analyses." Nature Protocols 11, no. 11:2049-2053. PNNL-SA-119986. doi:10.1038/nprot.2016.148
  • Zhang H., T. Liu, Z. Zhang, S.H. Payne, B. Zhang, J.E. McDermott, and J. Zhou, et al. 2016. "Integrated proteogenomic characterization of human high grade serous ovarian cancer." Cell 166, no. 3:755-765. PNNL-SA-107151. doi:10.1016/j.cell.2016.05.069
  • Zhang X., M.V. Romm, X. Zheng, E.M. Zink, Y. Kim, K.E. Burnum-Johnson, and D.J. Orton, et al. 2016. "SPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in bio?uids." Clinical Mass Spectrometry 2. PNNL-SA-117436. doi:10.1016/j.clinms.2016.11.002


  • Aylward F.O., L. Khadempour, D. Tremmel, B.R. McDonald, C.D. Nicora, S. Wu, and R.J. Moore, et al. 2015. "Enrichment and Broad Representation of Plant Biomass-Degrading Enzymes in the Specialized Hyphal Swellings of Leucoagaricus gongylophorus, the Fungal Symbiont of Leaf-Cutter Ants." PLoS One 10, no. 8:e0134752. PNNL-SA-108498. doi:10.1371/journal.pone.0134752
  • Baker E.S., K.E. Burnum-Johnson, Y.M. Ibrahim, D.J. Orton, M.E. Monroe, R.T. Kelly, and R.J. Moore, et al. 2015. "Enhancing Bottom-up and Top-down Proteomic Measurements with Ion Mobility Separations." Proteomics 15, no. 16:2766-2776. PNNL-SA-107785. doi:10.1002/pmic.201500048
  • Chen T., T.L. Fillmore, S.A. Prost, R.J. Moore, Y.M. Ibrahim, and R.D. Smith. 2015. "Orthogonal Injection Ion Funnel Interface Providing Enhanced Performance for Selected Reaction Monitoring-Triple Quadruple Mass Spectrometry." Analytical Chemistry 87, no. 14:7326-7331. PNNL-SA-109430. doi:10.1021/acs.analchem.5b01482
  • Xu Z., C. Wu, F. Xie, G.W. Slysz, N. Tolic, M.E. Monroe, and V.A. Petyuk, et al. 2015. "Comprehensive Quantitative Analysis of Ovarian and Breast Cancer Tumor Peptidomes." Journal of Proteome Research 14, no. 1:422-433. PNNL-SA-103951. doi:10.1021/pr500840w


  • Amidan B.G., D.J. Orton, B.L. Lamarche, M.E. Monroe, R.J. Moore, A.M. Venzin, and R.D. Smith, et al. 2014. "Signatures for Mass Spectrometry Data Quality." Journal of Proteome Research 13, no. 4:2215-2222. PNNL-SA-97216. doi:10.1021/pr401143e
  • Baker E.S., K.E. Burnum-Johnson, J.M. Jacobs, D.L. Diamond, R.N. Brown, Y.M. Ibrahim, and D.J. Orton, et al. 2014. "Advancing the High Throughput Identification of Liver Fibrosis Protein Signatures Using Multiplexed Ion Mobility Spectrometry." Molecular and Cellular Proteomics 13, no. 4:1119-1127. PNNL-SA-90826. doi:10.1074/mcp.M113.034595
  • Cao L., N. Tolic, Y. Qu, D. Meng, R. Zhao, Q. Zhang, and R.J. Moore, et al. 2014. "Characterization of intact N- and O-linked glycopeptides using higher energy collisional dissociation." Analytical Biochemistry 452. PNNL-SA-99189. doi:10.1016/j.ab.2014.01.003
  • Cox J.T., S.R. Kronewitter, A.K. Shukla, R.J. Moore, R.D. Smith, and K. Tang. 2014. "High Sensitivity Combined with Extended Structural Coverage of Labile Compounds via Nanoelectrospray Ionization at Subambient Pressures." Analytical Chemistry 86, no. 19:9504-9511. PNNL-SA-102134. doi:10.1021/ac502767y
  • Guo J., A.Y. Nguyen, Z. Dai, D. Su, M.J. Gaffrey, R.J. Moore, and J.M. Jacobs, et al. 2014. "Proteome-wide Light/Dark Modulation of Thiol Oxidation in Cyanobacteria Revealed by Quantitative Site-Specific Redox Proteomics." Molecular & Cellular Proteomics. MCP 13, no. 12:3270-3285. PNNL-SA-100244. doi:10.1074/mcp.M114.041160
  • Hyung S., P.D. Piehowski, R.J. Moore, D.J. Orton, A.A. Schepmoes, T.R. Clauss, and R.K. Chu, et al. 2014. "Microscale Depletion of High Abundance Proteins in Human Biofluids using IgY14 Immunoaffinity Resin: Analysis of Human Plasma and Cerebrospinal Fluid." Analytical and Bioanalytical Chemistry 406, no. 28:7117-7125. PNNL-SA-92758. doi:10.1007/s00216-014-8058-3
  • Kronewitter S.R., G.W. Slysz, I. Marginean, C.D. Hagler, B.L. Lamarche, R. Zhao, and M.Y. Harris, et al. 2014. "GlyQ-IQ: Glycomics Quintavariate-Informed Quantification with High-Performance Computing and GlycoGrid 4D Visualization." Analytical Chemistry 86, no. 13:6268-6276. PNNL-SA-100272. doi:10.1021/ac501492f
  • Kronewitter S.R., I. Marginean, J.T. Cox, R. Zhao, C.D. Hagler, A.K. Shukla, and T.S. Carlson, et al. 2014. "Polysialylated N-Glycans Identified in Human Serum Through Combined Developments in Sample Preparation, Separations and Electrospray ionization-mass spectrometry." Analytical Chemistry 86, no. 17:8700-10. PNNL-SA-102819. doi:10.1021/ac501839b
  • Mertins P., F. Yang, T. Liu, D. Mani, V.A. Petyuk, M. Gillette, and K. Clauser, et al. 2014. "Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels." Molecular & Cellular Proteomics. MCP 13, no. 7:1690-1704. PNNL-SA-98702. doi:10.1074/mcp.M113.036392
  • Nakayasu E.S., S. Wu, M.A. Sydor, A.K. Shukla, K.K. Weitz, R.J. Moore, and K.K. Hixson, et al. 2014. "A Method to determine lysine acetylation stoichiometries." International Journal of Proteomics 2014. PNNL-SA-96571. doi:10.1155/2014/730725
  • Sigdel T.K., N. Salomonis, C.D. Nicora, S. Ryu, J. He, V. Dinh, and D.J. Orton, et al. 2014. "The Identification of Novel Potential Injury Mechanisms and Candidate Biomarkers in Renal Allograft Rejection by Quantitative Proteomics." Molecular & Cellular Proteomics. MCP 13, no. 2:621-631. PNWD-SA-10124. doi:10.1074/mcp.M113.030577
  • Smith J.S., T.E. Angel, C. Chavkin, D.J. Orton, R.J. Moore, and R.D. Smith. 2014. "Characterization of individual mouse cerebrospinal fluid proteomes." Proteomics 14, no. 9:1102-1106. PNNL-SA-93378. doi:10.1002/pmic.201300241
  • Wu C., T. Shi, J.N. Brown, J. He, Y. Gao, T.L. Fillmore, and A.K. Shukla, et al. 2014. "Expediting SRM assay development for large-scale targeted proteomics experiments." Journal of Proteome Research 13, no. 10:4479-87. PNNL-SA-102906. doi:10.1021/pr500500d
  • Wu S., J.N. Brown, N. Tolic, D. Meng, X. Liu, H. Zhang, and R. Zhao, et al. 2014. "Quantitative Analysis of Human Salivary Gland-Derived Intact Proteome Using Top-Down Mass Spectrometry." Proteomics 14, no. 10:1211-1222. PNNL-SA-83095. doi:10.1002/pmic.201300378
  • Zhang Q., M.M. Matzke, A.A. Schepmoes, R.J. Moore, B.M. Webb-Robertson, Z. Hu, and M.E. Monroe, et al. 2014. "High and Low Doses of Ionizing Radiation Induce Different Secretome Profiles in a Human Skin Model." PLoS One 9, no. 3:Article No. e92332. PNNL-SA-98075. doi:10.1371/journal.pone.0092332


  • Aryal U.K., S.J. Callister, S. Mishra, X. Zhang, J.I. Shutthanandan, T.E. Angel, and A.K. Shukla, et al. 2013. "Proteome Analyses of Strains ATCC 51142 and PCC 7822 of the Diazotrophic Cyanobacterium Cyanothece sp under Culture Conditions Resulting in Enhanced H-2 Production." Applied and Environmental Microbiology 79, no. 4:1070-1077. PNNL-SA-90813. doi:10.1128/AEM.02864-12
  • Finnerty C.C., M.G. Jeschke, W. Qian, A. Kaushal, W. Xiao, T. Liu, and M.A. Gritsenko, et al. 2013. "DETERMINATION OF BURN PATIENT OUTCOME BY LARGE-SCALE QUANTITATIVE DISCOVERY PROTEOMICS." Critical Care Medicine 41, no. 6:1421-1434. PNWD-SA-9845. doi:10.1097/CCM.0b013e31827c072e
  • Kim J., Z. Dai, U.K. Aryal, R.J. Moore, D.G. Camp, S.E. Baker, and R.D. Smith, et al. 2013. "Resin-assisted Enrichment of N-terminal Peptides for Characterizing Proteolytic Processing." Analytical Chemistry 85, no. 14:6826-6832. PNNL-SA-92785. doi:10.1021/ac401000q
  • Piehowski P.D., V.A. Petyuk, D.J. Orton, F. Xie, R.J. Moore, M. Ramirez Restrepo, and A. Engel, et al. 2013. "Sources of Technical Variability in Quantitative LC-MS Proteomics: Human Brain Tissue Sample Analysis." Journal of Proteome Research 12, no. 5:2128-2137. PNNL-SA-92104. doi:10.1021/pr301146m
  • Qu Y., S. Wu, R. Zhao, E.M. Zink, D.J. Orton, R.J. Moore, and D. Meng, et al. 2013. "Automated Immobilized Metal Affinity Chromatography System for Enrichment of Escherichia coli Phosphoproteome." Electrophoresis 34, no. 11:1619-1626. PNNL-SA-92228. doi:10.1002/elps.201200628
  • Shi T., T.L. Fillmore, Y. Gao, R. Zhao, J. He, A.A. Schepmoes, and C.D. Nicora, et al. 2013. "Long-Gradient Separations Coupled with Selected Reaction Monitoring for Highly Sensitive, Large Scale Targeted Protein Quantification in a Single Analysis." Analytical Chemistry 85, no. 19:9196-9203. PNNL-SA-96700. doi:10.1021/ac402105s
  • Shi T., X. Sun, Y. Gao, T.L. Fillmore, A.A. Schepmoes, R. Zhao, and J. He, et al. 2013. "Targeted quantification of low ng/mL level proteins in human serum without immunoaffinity depletion." Journal of Proteome Research 12, no. 7:3353-3361. PNNL-SA-92544. doi:10.1021/pr400178v
  • Shvartsburg A.A., T.A. Seim, W.F. Danielson, R.V. Norheim, R.J. Moore, G.A. Anderson, and R.D. Smith. 2013. "High-Definition Differential Ion Mobility Spectrometry with Resolving Power up to 500." Journal of the American Society for Mass Spectrometry 24, no. 1:109-114. PNNL-SA-88665. doi:10.1007/s13361-012-0517-5
  • Wu S., R.N. Brown, S.H. Payne, D. Meng, R. Zhao, N. Tolic, and L. Cao, et al. 2013. "Top-down characterization of the post-translationally modified intact periplasmic proteome of the bacterium Novosphingobium aromaticivorans." International Journal of Proteomics 2013. PNNL-SA-91327. doi:10.1155/2013/279590
  • Zhou J., R.K. Krovvidi, Y. Gao, H. Gao, B.O. Petritis, A. De, and C. Miller-Graziano, et al. 2013. "Trauma-associated Human Neutrophil Alterations Revealed by Comparative Proteomics Profiling." Proteomics - Clinical Applications 7, no. 7-8:571-583. PNWD-SA-9434. doi:10.1002/prca.201200109


  • Gao X., Q. Zhang, D. Meng, G. Isaac, R. Zhao, T.L. Fillmore, and R.K. Chu, et al. 2012. "A reversed-phase capillary ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method for comprehensive top-down/bottom-up lipid profiling." Analytical and Bioanalytical Chemistry 402, no. 9:2923-2933. PNWD-SA-9553.
  • Lee J., S. Hyung, D. Mun, H. Jung, H. Kim, H. Lee, and S. Kim, et al. 2012. "Fully automated multifunctional ultrahigh pressure liquid chromatography system for advanced proteome analyses." Journal of Proteome Research 11, no. 8:4373-4381. PNNL-SA-88005. doi:10.1021/pr3004166
  • Marginean I., S.R. Kronewitter, R.J. Moore, G.W. Slysz, M.E. Monroe, G.A. Anderson, and K. Tang, et al. 2012. "Improving N-Glycan Coverage using HPLC-MS with Electrospray Ionization at Subambient Pressure." Analytical Chemistry 84, no. 21:9208-9213. PNNL-SA-89077. doi:10.1021/ac301961u
  • Perera R.M., C. Riley, G. Isaac, A. Hopf- Jannasch, R.J. Moore, K.K. Weitz, and L. Pasa-Tolic, et al. 2012. "Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells." PLoS Pathogens 8, no. 3:Article No. e1002584. PNNL-SA-83173. doi:10.1371/journal.ppat.1002584
  • Shi T., T.L. Fillmore, X. Sun, R. Zhao, A.A. Schepmoes, M. Hossain, and F. Xie, et al. 2012. "Antibody-free, targeted mass-spectrometric approach for quantification of proteins at low picogram per milliliter levels in human plasma/serum." Proceedings of the National Academy of Sciences of the United States of America 109, no. 38:15395-15400. PNNL-SA-83776. doi:10.1073/pnas.1204366109
  • Tian Z., N. Tolic, R. Zhao, R.J. Moore, S.M. Hengel, E.W. Robinson, and D.L. Stenoien, et al. 2012. "Enhanced top-down characterization of histone post-translational modifications." Genome Biology 13, no. 10:R86. PNNL-SA-90867. doi:10.1186/gb-2012-13-10-r86
  • Varnum S.M., B.M. Webb-Robertson, J.G. Pounds, R.J. Moore, R.D. Smith, C. Frevert, and S.J. Skerret, et al. 2012. "Proteomic analysis of bronchoalveolar lavage fluid proteins from mice infected with Francisella tularensis ssp novicida." Journal of Proteome Research 11, no. 7:3690-3703. PNNL-SA-86269.
  • Zhou J., G.P. Dann, T. Shi, L. Wang, X. Gao, D. Su, and C.D. Nicora, et al. 2012. "Simple Sodium Dodecyl Sulfate-Assisted Sample Preparation Method for LC-MS-based Proteomic Applications." Analytical Chemistry 84, no. 6:2862-2867. PNNL-SA-84751. doi:10.1021/ac203394r


  • Aryal U.K., J. Stockel, R.K. Krovvidi, M.A. Gritsenko, M.E. Monroe, R.J. Moore, and D.W. Koppenaal, et al. 2011. "Dynamic proteomic profiling of a unicellular cyanobacterium Cyanothece ATCC51142 across light-dark diurnal cycles." BMC Systems Biology 5. PNNL-SA-81418. doi:10.1186/1752-0509-5-194
  • Frank A.M., M.E. Monroe, A.R. Shah, J.J. Carver, N. Bandeira, R.J. Moore, and G.A. Anderson, et al. 2011. "Spectral archives: extending spectral libraries to analyze both identified and unidentified spectra." Nature Methods 8, no. 7:587-591. PNNL-SA-79495. doi:10.1038/nmeth.1609
  • Hossain M., D.T. Kaleta, E.W. Robinson, T. Liu, R. Zhao, J.S. Page, and R.T. Kelly, et al. 2011. "Enhanced Sensitivity for Selected Reaction Monitoring-Mass Spectrometry-based Targeted Proteomics using a Dual-Stage Electrodynamic Ion Funnel Interface." Molecular & Cellular Proteomics. MCP 10, no. 2. PNNL-SA-70166. doi:10.1074/mcp.M000062-MCP201
  • Kim J., T.L. Fillmore, T. Liu, E.W. Robinson, M. Hossain, B.L. Champion, and R.J. Moore, et al. 2011. "18O-Labeled Proteome Reference as Global Internal Standards for Targeted Quantification by Selected Reaction Monitoring-Mass Spectrometry." Molecular & Cellular Proteomics. MCP 10, no. 12:Article No. M110.007302. PNNL-SA-77028. doi:10.1074/mcp.M110.007302
  • Schoenherr R.M., K.S. Kelly-Spratt, C. Lin, J.R. Whiteaker, T. Liu, T. Holzman, and I. Coleman, et al. 2011. "Proteome and Transcriptome Profiles of a Her2/Neu-driven Mouse Model of Breast Cancer." Proteomics - Clinical Applications 5, no. 3-4:179-188. PNNL-SA-72407. doi:10.1002/prca.201000037
  • Shen Y., N. Tolic, F. Xie, R. Zhao, S.O. Purvine, A.A. Schepmoes, and R.J. Moore, et al. 2011. "Effectiveness of CID, HCD, and ETD with FT MS/MS for degradomic-peptidomic analysis: comparison of peptide identification methods." Journal of Proteome Research 10, no. 9:3929-3943. PNNL-SA-75441. doi:10.1021/pr200052c
  • Shukla A.K., R. Zhang, D.J. Orton, R. Zhao, T.R. Clauss, R.J. Moore, and R.D. Smith. 2011. "Formation of iron complexs from trifluoroacetic acid based liquid chromatography mobile phases as interference ions in liquid chromatography/electrospray ionization mass spectrometric analysis." Rapid Communications in Mass Spectrometry 25, no. 10:1452-1456. PNNL-SA-68066. doi:10.1002/rcm.5017
  • Wang Y., F. Yang, M.A. Gritsenko, Y. Wang, T.R. Clauss, T. Liu, and Y. Shen, et al. 2011. "Reversed-Phase Chromatography with Multiple Fraction Concatenation Strategy for Proteome Profiling of Human MCF10A Cells." Proteomics 11, no. 10:2019-2026. PNNL-SA-75439. doi:10.1002/pmic.201000722
  • Zhang H., F. Yang, W. Qian, R.N. Brown, Y. Wang, E.D. Merkley, and J.H. Park, et al. 2011. "Identification of c-Type Heme-Containing Peptides Using Non-Activated Immobilized Metal Affinity Cchromatography Resin Enrichment and Higher-Energy Collisional Dissociation." Analytical Chemistry 83, no. 19:7260-7268. PNNL-SA-77198. doi:10.1021/ac2000829
  • Zhang H., K.E. Burnum, M.L. Luna, B.O. Petritis, J. Kim, W. Qian, and R.J. Moore, et al. 2011. "Quantitative proteomics analysis of adsorbed plasma proteins classifies nanoparticles with different surface properties and size." Proteomics 11, no. 23:4569-4577. PNNL-SA-74159. doi:10.1002/pmic.201100037


  • Baker E.S., E.A. Livesay, D.J. Orton, R.J. Moore, W.F. Danielson, D.C. Prior, and Y.M. Ibrahim, et al. 2010. "An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput Proteomic Studies." Journal of Proteome Research 9, no. 2:997-1006. PNNL-SA-67461. doi:10.1021/pr900888b
  • Fraga C.G., B.H. Clowers, R.J. Moore, and E.M. Zink. 2010. "Signature-Discovery Approach for Sample Matching of a Nerve-Agent Precursor using Liquid Chromatography-Mass Spectrometry, XCMS, and Chemometrics." Analytical Chemistry 82, no. 10:4165-4173. PNNL-SA-70105.
  • Jung H., S.O. Purvine, H. Kim, V.A. Petyuk, S. Hyung, M.E. Monroe, and D. Mun, et al. 2010. "Integrated Post-Experiment Monoisotopic Mass Refinement: An Integrated Approach to Accurately Assign Monoisotopic Precursor Masses to Tandem Mass Spectrometric Data." Analytical Chemistry 82, no. 20:8510-8518. PNNL-SA-74157. doi:10.1021/ac101388b
  • Qian W., B.O. Petritis, A. Kaushal, C.C. Finnerty, M.G. Jescheke, M.E. Monroe, and R.J. Moore, et al. 2010. "Plasma Proteome Response to Severe Burn Injury Revealed by 18O-Labeled “Universal” Reference-based Quantitative Proteomics." Journal of Proteome Research 9, no. 9:4779-4789. PNWD-SA-9014.
  • Shen Y., N. Tolic, T. Liu, R. Zhao, B.O. Petritis, M.A. Gritsenko, and D.G. Camp, et al. 2010. "Blood Peptidome-Degradome Profile of Breast Cancer." PLoS One 5, no. 10:Article No.: e13133. PNNL-SA-70095. doi:10.1371/journal.pone.0013133
  • Shen Y., T. Liu, N. Tolic, B.O. Petritis, R. Zhao, R.J. Moore, and S.O. Purvine, et al. 2010. "A strategy for degradomic-peptidomic analysis of the human blood plasma." Journal of Proteome Research 9, no. 5:2339-2346. PNNL-SA-71375. doi:10.1021/pr901083m
  • Tian Z., R. Zhao, N. Tolic, R.J. Moore, D.L. Stenoien, E.W. Robinson, and R.D. Smith, et al. 2010. "Two-dimensional liquid chromatography system for online top-down mass spectrometry." Proteomics 10, no. 20:3610-3620. PNNL-SA-73468. doi:10.1002/pmic.201000367
  • Zhang H., R.N. Brown, W. Qian, M.E. Monroe, S.O. Purvine, R.J. Moore, and M.A. Gritsenko, et al. 2010. "Quantitative analysis of cell surface membrane proteins using membrane-impermeable chemical probe coupled with 18O labeling." Journal of Proteome Research 9, no. 5:2160-2169. PNNL-SA-67314.
  • Zhou J., A.A. Schepmoes, X. Zhang, R.J. Moore, M.E. Monroe, J. Lee, and D.G. Camp, et al. 2010. "Improved LC-MS/MS Spectral Counting Statistics by Recovering Low Scoring Spectra Matched to Confidently Identified Peptide Sequences." Journal of Proteome Research 9, no. 11:5698-5704. PNNL-SA-74147. doi:10.1021/pr100508p


  • Chowdhury S.M., X. Du, N. Tolic, S. Wu, R.J. Moore, M.U. Mayer, and R.D. Smith, et al. 2009. "Identification of Cross-Linked Peptides after Click-Based Enrichment Using Sequential Collision-Induced Dissociation and Electron Transfer Dissociation Tandem Mass Spectrometry." Analytical Chemistry 81, no. 13:5524-5532. PNNL-SA-61747. doi:10.1021/ac900853k
  • Marginean I., R.T. Kelly, R.J. Moore, D.C. Prior, B.L. Lamarche, K. Tang, and R.D. Smith. 2009. "Selection of the Optimum Electrospray Voltage for Gradient Elution LC-MS Measurements." Journal of the American Society for Mass Spectrometry 20, no. 4:682-688. PNNL-SA-62318.
  • Qian W., T. Liu, V.A. Petyuk, M.A. Gritsenko, B.O. Petritis, A.D. Polpitiya, and A. Kaushal, et al. 2009. "Large-Scale Multiplexed Quantitative Discovery Proteomics Enabled by the Use of an O-18-Labeled “Universal” Reference Sample." Journal of Proteome Research 8, no. 1:290-299. PNNL-SA-57317.
  • Weber T.J., L.K. Opresko, D.M. Waisman, G.J. Newton, R.D. Quesenberry, N. Bollinger, and R.J. Moore, et al. 2009. "Regulation of the Low Dose Radiation Paracrine-Specific Anchorage-Independent Growth Response by Annexin A2." Radiation Research 172, no. 1:96-105. PNNL-SA-56968. doi:10.1667/RR1220.1
  • Yang F., S. Wu, D.L. Stenoien, R. Zhao, M.E. Monroe, M.A. Gritsenko, and S.O. Purvine, et al. 2009. "Combined Pulsed-Q dissociation and electron transfer dissociation for identification and quantitation of iTRAQ-labeled phosphopeptides." Analytical Chemistry 81, no. 10:4137-4143. PNNL-SA-63701. doi:10.1021/ac802605m
  • Zhou J., B.O. Petritis, K. Petritis, A.D. Norbeck, K.K. Weitz, R.J. Moore, and D.G. Camp, et al. 2009. "Mouse-Specific Tandem IgY7-SuperMix Immunoaffinity Separations for Improved LC-MS/MS Coverage of the Plasma Proteome." Journal of Proteome Research 8, no. 11:5387-5395. PNNL-SA-67312.


  • Ding J., C.M. Sorensen, N. Jaitly, H. Jiang, D.J. Orton, M.E. Monroe, and R.J. Moore, et al. 2008. "Application of the accurate mass and time tag approach in studies of the human blood lipidome." Journal of Chromatography B 871, no. 2:243-252. PNNL-SA-58868. doi:10.1016/j.jchromb.2008.04.040
  • Ding S., Y. Wang, J.M. Jacobs, W. Qian, F. Yang, A.V. Tolmachev, and X. Du, et al. 2008. "Quantitative Phosphoproteome Analysis of Lysophosphatidic Acid Induced Chemotaxis applying Dual-step 18O Labeling Coupled with Immobilized Metal-ion Affinity Chromatography." Journal of Proteome Research 7, no. 10:4215-24. PNNL-SA-52241. doi:10.1021/pr7007785
  • Livesay E.A., K. Tang, B.K. Taylor, M.A. Buschbach, D.F. Hopkins, B.L. Lamarche, and R. Zhao, et al. 2008. "Fully automated four-column capillary LC-MS system for maximizing throughput in proteomic analyses." Analytical Chemistry 80, no. 1:294-302. PNNL-SA-56532. doi:10.1021/ac701727r
  • Lopez-Ferrer D., K. Petritis, K.K. Hixson, T.H. Heibeck, R.J. Moore, M.E. Belov, and D.G. Camp, et al. 2008. "Application of pressurized solvents for ultrafast trypsin hydrolysis in proteomics: Proteomics on the fly." Journal of Proteome Research 7, no. 8:3276-3281. PNNL-SA-60252. doi:10.1021/pr7008077
  • Lopez-Ferrer D., T.H. Heibeck, K. Petritis, K.K. Hixson, W. Qian, M.E. Monroe, and A.M. Mayampurath, et al. 2008. "Rapid Sample Processing For LC-MS Based Quantitative Proteomics Using High Intensity Focused Ultrasounds." Journal of Proteome Research 7, no. 9:3860-3867. PNNL-SA-59400. doi:10.1021/pr800161x
  • Manes N.P., R.D. Estep, H.M. Mottaz, R.J. Moore, T.R. Clauss, M.E. Monroe, and X. Du, et al. 2008. "Comparative Proteomics of Human Monkeypox and Vaccinia Intracellular Mature and Extracellular Enveloped Virions." Journal of Proteome Research 3. PNNL-SA-54048. doi:10.1021/pr070432+
  • Metz T.O., W. Qian, J.M. Jacobs, M.A. Gritsenko, R.J. Moore, A.D. Polpitiya, and M.E. Monroe, et al. 2008. "Application of proteomics in the discovery of candidate protein biomarkers in a Diabetes Autoantibody Standardization Program sample subset." Journal of Proteome Research 7, no. 2:698-707. PNNL-SA-56533. doi:10.1021/pr700606w
  • Petyuk V.A., N. Jaitly, R.J. Moore, J. Ding, T.O. Metz, K. Tang, and M.E. Monroe, et al. 2008. "Elimination of Systematic Mass Measurement Errors in Liquid Chromatography-Mass Spectrometry Based Proteomics using Regression Models and a priori Partial Knowledge of the Sample Content." Analytical Chemistry 80, no. 3:693-706. PNNL-SA-56693. doi:10.1021/ac701863d
  • Shen Y., K.K. Hixson, N. Tolic, D.G. Camp, S.O. Purvine, R.J. Moore, and R.D. Smith. 2008. "Mass Spectrometry Analysis of Proteome-wide Proteolytic Post-translational Degradation of Proteins." Analytical Chemistry 80, no. 15:5819-5828. PNNL-SA-58041. doi:10.1021/ac800077w
  • Shen Y., N. Tolic, K.K. Hixson, S.O. Purvine, L. Pasa-Tolic, W. Qian, and J.N. Adkins, et al. 2008. "Proteome-wide identification of proteins and their modifications with decreased ambiguities and improved false discovery rates using unique sequence tags." Analytical Chemistry 80, no. 6:1871-82. PNNL-SA-56012. doi:10.1021/ac702328x
  • Tolmachev A.V., M.E. Monroe, S.O. Purvine, R.J. Moore, N. Jaitly, J.N. Adkins, and G.A. Anderson, et al. 2008. "Characterization of Strategies for Obtaining Confident Identifications in Bottom-Up Proteomics Measurements Using Hybrid FTMS instruments." Analytical Chemistry 80, no. 22:8514-8525. PNNL-SA-61186. doi:10.1021/ac801376g
  • Zhang Q., A.A. Schepmoes, J.W. Brock, S. Wu, R.J. Moore, S.O. Purvine, and J. Baynes, et al. 2008. "Improved Methods for the Enrichment and Analysis of Glycated Peptides." Analytical Chemistry 80, no. 24:9822-9829. PNNL-SA-61746. doi:10.1021/ac801704j


  • Kim J., K. Petritis, Y. Shen, D.G. Camp, R.J. Moore, and R.D. Smith. 2007. "Phosphopeptide elution times in reversed-phase liquid chromatography." Journal of Chromatography A 1172, no. 1:9-18. PNNL-SA-53249. doi:10.1016/j.chroma.2007.09.032
  • Resch W., K.K. Hixson, R.J. Moore, M.S. Lipton, and B. Moss. 2007. "Protein Composition of the Vaccinia Virus Mature Virion." Virology 358, no. 1:233-247. PNNL-SA-51306.
  • Wang Y., S. Ding, W. Wang, J.M. Jacobs, W. Qian, R.J. Moore, and F. Yang, et al. 2007. "Profiling Signaling Polarity in Chemotactic Cells." Proceedings of the National Academy of Sciences of the United States of America 104, no. 20:8328-8333. PNNL-SA-51866. doi:10.1073/pnas.0701103104
  • Yang F., N. Jaitly, H. Jayachandran, Q. Lou, M.E. Monroe, X. Du, and M.A. Gritsenko, et al. 2007. "Applying a Targeted Label-free Approach using LC-MS AMT Tags to Evaluate Changes in Protein Phosphorylation Following Phosphatase Inhibition." Journal of Proteome Research 6, no. 11:4489-4497. PNNL-SA-52332. doi:10.1021/pr070068e
  • Zhang Q., W. Qian, T.V. Knyushko, T.R. Clauss, S.O. Purvine, R.J. Moore, and C.A. Sacksteder, et al. 2007. "A Method for Selective Enrichment and Analysis of Nitrotyrosine-Containing Peptides in Complex Proteome Samples." Journal of Proteome Research 6, no. 6:2257-2268. PNNL-SA-53248. doi:10.1021/pr0606934


  • Fang R., D.A. Elias, M.E. Monroe, Y. Shen, M. McIntosh, P. Wang, and C.D. Goddard, et al. 2006. "Differential Label-free Quantitative Proteomic Analysis of Shewanella oneidensis Cultured under Aerobic and Suboxic Conditions by Accurate Mass and Time Tag Approach." Molecular & Cellular Proteomics. MCP 5, no. 4:714-725. PNNL-SA-47983. doi:10.1074/mcp.M500301-MCP200
  • Hixson K.K., J.N. Adkins, S.E. Baker, R.J. Moore, R.D. Smith, S.L. McCutchen-Maloney, and M.S. Lipton. 2006. "Biomarker Candidate Identification in Yersinia Pestis Using Organism-Wide Semiquantitative Proteomics." Journal of Proteome Research 5, no. 11:3008-3017. PNNL-SA-49565.
  • Kelly R.T., J.S. Page, Q. Luo, R.J. Moore, D.J. Orton, K. Tang, and R.D. Smith. 2006. "Chemically Etched Open Tubular and Monolithic Emitters for Nanoelectrospray Ionization Mass Spectrometry." Analytical Chemistry 78, no. 22:7796-7801. PNNL-SA-50640.
  • Liu T., W. Qian, H.M. Mottaz, M.A. Gritsenko, A.D. Norbeck, R.J. Moore, and S.O. Purvine, et al. 2006. "Evaluation of Multi-Protein Immunoaffinity Subtraction for Plasma Proteomics and Candidate Biomarker Discovery Using Mass Spectrometry." Molecular & Cellular Proteomics. MCP 5, no. 11:2167-2174. PNWD-SA-7363.
  • Liu T., W. Qian, M.A. Gritsenko, W. Xiao, L.L. Moldawer, A. Kaushal, and M.E. Monroe, et al. 2006. "High Dynamic Range Characterization of the Trauma Patient Plasma Proteome." Molecular & Cellular Proteomics. MCP 5, no. 10:1899-1913. PNWD-SA-7271. doi:10.1074/mcp.M600068-MCP200
  • Luo Q., K. Tang, F. Yang, A. Elias, Y. Shen, R.J. Moore, and R. Zhao, et al. 2006. "More sensitive and quantitative proteomic measurements using very low flow rate porous silica monolithic LC columns with electrospray ionization-mass spectrometry." Journal of Proteome Research 5, no. 5:1091-1097. PNNL-SA-47984.
  • Petritis K., L.J. Kangas, B. Yan, M.E. Monroe, E.F. Strittmatter, W. Qian, and J.N. Adkins, et al. 2006. "Improved peptide elution time prediction for reversed-phase liquid chromatography-MS by incorporating peptide sequence information." Analytical Chemistry 78, no. 14:5026-5039. PNNL-SA-50263. doi:10.1021/ac060143p
  • Wang H.H., W. Qian, M.H. Chin, V.A. Petyuk, R.C. Barry, T. Liu, and M.A. Gritsenko, et al. 2006. "Characterization of the Mouse Brain Proteome Using Global Proteomic Analysis Complemented with Cysteinyl-Peptide Enrichment." Journal of Proteome Research 5, no. 2:361-369. PNNL-SA-46752.
  • Zhang W., D.E. Culley, M.A. Gritsenko, R.J. Moore, L. Nie, J.C. Scholten, and K. Petritis, et al. 2006. "LC-MS/MS based proteomic analysis and functional inference of hypothetical proteins in Desulfovibrio vulgaris." Biochemical and Biophysical Research Communications 349, no. 4:1412-1419. PNNL-SA-45667. doi:10.1016/j.bbrc.2006.09.019
  • Zhang W., D.E. Culley, M.A. Gritsenko, R.J. Moore, L. Nie, J.C. Scholten, and K. Petritis, et al. 2006. "LC-MS/MS Based Proteomic Analysis and Functional Inference of Hypothetical Proteins in Desulfovibrio Vulgaris." Biochemical and Biophysical Research Communications 349, no. 4:1412-1419. PNNL-SA-51397. doi:10.1016/j.bbrc.2006.09.019
  • Zhang W., M.A. Gritsenko, R.J. Moore, D.E. Culley, L. Nie, K. Petritis, and E.F. Strittmatter, et al. 2006. "A Proteomic View of Desulfovibrio Vulgaris Metabolim as Determined by Liquid Chromatography Coupled with Tandem Mass Spectrometry." Proteomics 6, no. 15:4286-4299. PNNL-SA-45506. doi:10.1002/pmic.200500930


  • Liu T., W. Qian, M.A. Gritsenko, D.G. Camp, M.E. Monroe, R.J. Moore, and R.D. Smith. 2005. "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry." Journal of Proteome Research 4, no. 6:2070-2080. PNNL-SA-44967.
  • Liu T., W. Qian, W.U. Chen, J.M. Jacobs, R.J. Moore, D.J. Anderson, and M.A. Gritsenko, et al. 2005. "Improved Proteome Coverage by Using High Efficiency Cysteinyl-peptide Enrichment: The Human Mammary Epithelial Cell Proteome." Proteomics 5, no. 5:1263-1273. PNNL-SA-42468.
  • Luo Q., Y. Shen, K.K. Hixson, R. Zhao, F. Yang, R.J. Moore, and H.M. Mottaz, et al. 2005. "Preparation of 20-µm-i.d. Silica-based Monolithic Columns and Application for Proteomic Analysis." Analytical Chemistry 77, no. 15:5028-5035. PNNL-SA-44543.
  • Markillie L.M., C.T. Lin, J.N. Adkins, D.L. Auberry, E.A. Hill, B.S. Hooker, and P.A. Moore, et al. 2005. "Simple Protein Complex Purification and Identification Method Suitable for High- throughput Mapping of Protein Interaction Networks." Journal of Proteome Research 4, no. 2:268-274. PNNL-SA-42494. doi:10.1021/pr049847a
  • Qian W., J.M. Jacobs, D.G. Camp, M.E. Monroe, R.J. Moore, M.A. Gritsenko, and S.E. Calvano, et al. 2005. "Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry." Proteomics 5, no. 2:572-584. PNNL-SA-40692. doi:10.1002/pmic.200400942
  • Qian W., M.E. Monroe, T. Liu, J.M. Jacobs, G.A. Anderson, Y. Shen, and R.J. Moore, et al. 2005. "Quantitative Proteome Analysis of Human Plasma Following in vivo Lipopolysaccharide Administration using O-16/O-18 Labeling and the Accurate Mass and Time Tag Approach." Molecular & Cellular Proteomics. MCP 4, no. 5:700-709. PNNL-SA-44302.
  • Shen Y., E.F. Strittmatter, R. Zhang, T.O. Metz, R.J. Moore, F. Li, and H.R. Udseth, et al. 2005. "Making broad proteome protein measurements in 1-5 min using high-speed RPLC separations and high-accuracy mass measurments." Analytical Chemistry 77, no. 23:7763-7773. PNNL-SA-45881. doi:10.1021/ac051257o
  • Shen Y., J. Kim, E.F. Strittmatter, J.M. Jacobs, D.G. Camp, R. Fang, and N. Tolic, et al. 2005. "Characterization of the human blood plasma proteome." Proteomics 5, no. 15:4034-4045. PNWD-SA-6708.
  • Shen Y., R. Zhang, R.J. Moore, J. Kim, T.O. Metz, K.K. Hixson, and R. Zhao, et al. 2005. "Automated 20 kpsi RPLC-MS and MS/MS with chromatographic peak capacities of 1000-1500 and capabilities in proteomics and metabolomics." Analytical Chemistry 77, no. 10:3090-3100. PNNL-SA-43807.
  • Wang H.H., W. Qian, H.M. Mottaz, T.R. Clauss, D.J. Anderson, R.J. Moore, and D.G. Camp, et al. 2005. "Development and Evaluation of a Micro- and Nanoscale Proteomic Sample Preparation Method." Journal of Proteome Research 4, no. 6:2397-2403. PNNL-SA-45347. doi:10.1021/pr050160f


  • Belov M.E., G.A. Anderson, M.A. Wingerd, H.R. Udseth, K. Tang, D.C. Prior, and K.R. Swanson, et al. 2004. "An Automated High Performance Capillary Liquid Chromatography Fourier Transform Ion Cyclotron Resonance Mass Spectrometer for High-Throughput Proteomics." Journal of the American Society for Mass Spectrometry 15, no. 2:212-232. PNNL-SA-38749.
  • Jacobs J.M., H.M. Mottaz, L. Yu, D.J. Anderson, R.J. Moore, W.U. Chen, and K.J. Auberry, et al. 2004. "Multidimensional Proteome Analysis of Human Mammary Epithelial Cells." Journal of Proteome Research 3, no. 1:68-75. PNWD-SA-6087.
  • Prokisch H., C.M. Scharfe, D.G. Camp, W. Xiao, L. David, C. Andreoli, and M.E. Monroe, et al. 2004. "Integrative Analysis of the Mitochondrial Proteome in Yeast." PLoS Biology 2, no. 6:0795-0804. PNWD-SA-6619.
  • Shen Y., J.M. Jacobs, D.G. Camp, R. Fang, R.J. Moore, R.D. Smith, and W. Xiao, et al. 2004. "Ultra-High-Efficiency Strong Cation Exchange LC/RPLC/MS/MS for High Dynamic Range Characterization of the Human Plasma Proteome." Analytical Chemistry 76, no. 4:1134-1144. PNNL-SA-39155.
  • Vilkov A.N., B. Bogdanov, L. Pasa-Tolic, D.C. Prior, G.A. Anderson, C.D. Masselon, and R.J. Moore, et al. 2004. "Tailored Noise Waveform/ Collision-Induced Dissociation of Ions Stored in a Linear Ion Trap Combined with Liquid Chromatography/Fourier Transform Ion Cyclotron Resonance Mass Spectrometry." Rapid Communications in Mass Spectrometry 18, no. 22:2682-2690. PNNL-SA-42697.


  • Shen Y., R.J. Moore, R. Zhao, J. Blonder, D.L. Auberry, C.D. Masselon, and L. Pasa-Tolic, et al. 2003. "High-Efficiency On-Line Solid-Phase Extraction Coupling to 15-150 um I.D. Column Liquid Chromatography for Proteomic Analysis." Analytical Chemistry 75, no. 14:3596-3605. PNNL-SA-38207.


  • Adkins J.N., S.M. Varnum, K.J. Auberry, R.J. Moore, N. Angell, R.D. Smith, and D.L. Springer, et al. 2002. "Toward a Human Blood Serum Proteome: Analysis by Multidimensional Separation Coupled with Mass Spectrometry." Molecular & Cellular Proteomics. MCP 1, no. 12:947-955. PNWD-SA-5845.
  • Blonder J., M.B. Goshe, R.J. Moore, L. Pasa-Tolic, C.D. Masselon, M.S. Lipton, and R.D. Smith. 2002. "Enrichment of Integral Membrane Proteins for Proteomic Analysis Using Liquid Chromatography-Tandem Mass Spectrometry." Journal of Proteome Research 1, no. 4:351-360. PNNL-SA-36193.
  • Lipton M.S., L. Pasa-Tolic, G.A. Anderson, D.J. Anderson, D.L. Auberry, J.R. Battista, and M.J. Daly, et al. 2002. "Global Analysis of Deinococcus Radiodurans Proteome by Csing Accurate Mass Tags." Proceedings of the National Academy of Sciences of the United States of America 99, no. 17:11049-11054. PNNL-SA-35211.