PNNL

Dr. Paul Wilson is a senior biomedical scientist specializing in radiation biology. Paul earned a PhD in cellular and molecular radiobiology from Colorado State University (CSU) and completed a postdoctoral fellowship in DNA repair at Lawrence Livermore National Laboratory (LLNL). His research is funded by NASA and NASA's Translational Research Institute for Space Health (TRISH), NIAID's Radiation and Nuclear Countermeasures Program (RNCP), and DOE/NNSA. He and his team study the impacts of ionizing radiation exposures across a broad range of doses, dose rates, and linear energy transfer values using in vitro cell culture and in vivoanimal models; identify and test promising radiation medical countermeasures; and evaluate impacts of inter-individual genetic variation on radiation-associated health risks in exposed populations, including individuals inadvertently exposed during nuclear/radiological emergencies and astronauts on extended deep space missions. Paul is the PNNL lead for the Washington State BioS-ENDURES NASA Space Biology consortium (https://bios-endures.space) and also serves as a PNNL Laboratory Detailee to DOE's Office of Biological and Environmental Research (BER), Biological Systems Science Division (BSSD) for which he provides radiobiology and radiation physics expertise and assists in managing BER's Low Dose Radiation Research Program (LDRRP).

• Cancer Biology
• Cancer Genomics
• Cancer Research
• Cancer Stem Cells
• Cancer Therapeutics
• Chemical, Biological, Radiological, Nuclear, or Explosive (CBRNE) Response
• DNA Damage
• DNA Repair
• Irradiation
• Irradiation and Dosimetry
• Radiation Biology
• Radiation Damage
• Radiation Dosimetry and Measurement
• Radiation Effects
• Radiation Modeling and Simulation
• Radiation Therapy

• PhD in Radiological Health Sciences, Colorado State University
• BS in Physics, University of Washington
• BA in Biological Anthropology, University of Washington

Radiation Research Society

2025

• Li X., M.J. Gaffrey, M.A. Gritsenko, A.E. Gluth, J.B. Trejo, N.J. Day, and P.F. Wilson, et al. 2025. "A Mass Spectrometry-Based Proteomics Workflow for Concurrent Profiling of Protein Thiol Oxidation and Phosphorylation." In DNA Damage Detection. Methods in Molecular Biology, edited by T.A. Kato. 127-139. New York, New York:Humana. PNNL-SA-204642. doi:10.1007/978-1-0716-4574-1_17

2024

• Kato T., J. Maeda, H. Watanabe, S. Kawamura, and P.F. Wilson. 2024. "Simultaneous inhibition of ATM, ATR, and DNA-PK causes synergistic lethality." Biochemical and Biophysical Research Communications 738, no. _:Art. No. 150517. PNNL-SA-202226. doi:10.1016/j.bbrc.2024.150517

2023

• Diaz J., B.M. Kuhlman, N.P. Edenhoffer, A.C. Evans, K. Martin, P. Guida, and A. Rusek, et al. 2023. "Immediate Effects of Acute Mars Mission Equivalent Doses of SEP and GCR Radiation on the Murine Gastrointestinal System-Protective Effects of Curcumin-Loaded Nanolipoprotein Particles (cNLPs)." Frontiers in Astronomy and Space Sciences 10. PNNL-SA-180506. doi:10.3389/fspas.2023.1117811

2022

Jiang N, Xie B, Xiao W, Fan M, Xu S, Duan Y, Hamsafar Y, Evans AC, Huang J, Zhou W, Lin X, Ye N, Wanggou S, Chen W, Jing D, Fragoso RC, Dugger BN, Wilson PF, Coleman MA, Xia S, Li X, Sun LQ, Monjazeb AM, Wang A, Murphy WJ, Kung HJ, Lam KS, Chen HW, Li JJ. (2022). Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion. Nat. Commun. 13 (1): 1511. doi: 10.1038/s41467-022-29137-3. PMID: 35314680.

Bennett PV, Johnson AM, Ackerman SE, Chaudhary P, Keszenman DJ, Wilson PF. (2022). Dose-rate effects of protons and light ions for DNA damage induction, survival and transformation in apparently normal primary human fibroblasts. Radiat. Res. 197 (3): 298–313. doi: 10.1667/RADE-21-00138.1. PMID: 34910217.

Evans AC, Setzkorn T, Edmondson DA, Segelke H, Wilson PF, Matthay KK, Granger MM, Marachelian A, Haas-Kogan DA, DuBois, SG, Coleman MA. (2022). Peripheral blood transcript signatures after internal ¹³¹I-mIBG therapy in relapsed and refractory neuroblastoma patients identifies early and late biomarkers of internal ¹³¹I exposures. Radiat. Res. 197 (2): 101–112. doi: 10.1667/RADE-20-00173.1. PMID: 34673986.

2021

Johnson AM, Bennett PV, Sanidad KZ, Hoang A, Jardine JH, Keszenman DJ, Wilson PF. (2021). Evaluation of histone deacetylase inhibitors as radiosensitizers for proton and light ion radiotherapy. Front. Oncol. 11: 735940. doi: 10.3389/fonc.2021.735940. PMID: 34513712

2018

Low EK, Brudvik E, Kuhlman B, Wilson PF, Almeida-Porada G, Porada CD. (2018). Microgravity impairs DNA damage repair in human hematopoietic stem/progenitor cells and inhibits their differentiation into dendritic cells. Stem Cells Dev. 27 (18): 1257–1267. doi: 10.1089/scd.2018.0052. PMID: 29901426.

Almeida-Porada G, Rodman C, Kuhlman B, Brudvik E, Moon J, George S, Guida P, Sajuthi SP, Langefeld CD, Walker SJ, Wilson PF, Porada CD. (2018). Exposure of the bone marrow microenvironment to simulated solar and galactic cosmic radiation induces biological bystander effects on human hematopoiesis. Stem Cells Dev. 27 (18): 1237–1256. doi: 10.1089/scd.2018.0005. PMID: 29698131.

2017

Rodman C, Almeida-Porada G, George S, Moon J, Soker S, Pardee T, Beaty M, Guida P, Sajuthi SP, Langefeld CD, Walker SJ, Wilson PF, Porada CD. (2016). In vitro and in vivo assessment of direct effects of simulated solar and galactic cosmic radiation on human hematopoietic stem/progenitor cells. Leukemia 31 (6): 1398–1407. doi: 10.1038/leu.2016.344. PMID: 27881872.

2016

Wilson PF. (2016). Magnification of inter-individual variation in biological responses after low doses and dose-rates of ionizing radiation. Health Phys. 110 (3): 296–298. doi: 10.1097/HP.0000000000000453. PMID: 26808888.

2015

Yan X, Sasi SP, Gee H, Lee J, Yang Y, Mehrzad R, Onufrak J, Song J, Enderling H, Agarwal A, Rahimi L, Morgan J, Wilson PF, Carrozza J, Walsh K, Kishore R, Goukassian DA. (2015). Correction: Cardiovascular risks associated with low dose ionizing particle radiation.. PLoS One 10 (11). doi: 10.1371/journal.pone.0142764. PMID: 26544605.

2014

Yan X, Sasi SP, Gee H, Lee J, Yang Y, Mehrzad R, Onufrak J, Song J, Enderling H, Agarwal A, Rahimi L, Morgan J, Wilson PF, Carrozza J, Walsh K, Kishore R, Goukassian DA. (2015). Correction: Cardiovascular risks associated with low dose ionizing particle radiation.. PLoS One 9 (10). doi: 10.1371/journal.pone.0110269. PMID: 25337914.

Saha JP, Wilson PF, Thieberger P, Lowenstein D, Wang M, Cucinotta F. (2014). Biological characterization of low-energy ions with high-energy deposition on human cells. Radiat. Res. 182 (3): 282–291. 10.1667/RR13747.1.

Lin YF, Nagasawa H, Little JB, Kato TA, Shih HY, Xie XJ, Wilson PF, Brogan JR, Kurimasa A, Chen DJ, Bedford JS, Chen BP. (2014). Differential Radiosensitivity Phenotypes of DNA-PKcs Mutations Affecting NHEJ and HRR Systems following Irradiation with Gamma-Rays or Very Low Fluences of Alpha Particles. PloS One 9 (4): e93579. doi: 10.1371/journal.pone.0093579. PMID: 24714417.