Post Doctorate Research Associate
Post Doctorate Research Associate

Biography

Dr. Michael Taylor is a post doctoral research associate with the Biogeochemical Transformations team in PNNL’s Environmental Molecular Sciences Division and the Environmental Molecular Sciences Laboratory (EMSL) user program. As an analytical chemist who specializes in mass spectrometry imaging (MSI), Taylor has worked in biomaterial and biological MSI for over six years. His research focus involves the application of MSI methods for metabolomics. He has directed research projects involving the application of secondary ion mass spectrometry (SIMS) to understand biological systems, which included drug penetration in single cells, metabolomic profiling in tumor growth, and plant systems biology.  

He joined PNNL in 2019 to develop a laser ablation electrospray ionization (LAESI) microscope for in situ metabolomics. Recently, he received funding for the M/Q Initiative to understand the effect of salt on laser and primary ion-molecule desorption from surfaces, combining molecular dynamic-based simulations with desorption experimental data. 

 

Research Interest

  • Mass spectrometry imaging 

  • Surface analysis 

  • SIMS  

  • Matrix assisted laser desorption ionization  

  • LAESI 

  • X-ray photoelectron spectroscopy  

  • Machine learning  

  • Multivariate analysis 

  • Surface modification 

  • Polymer synthesis/polymer chemistry 

  • Biomaterial modification

Education

  • PhD in Pharmacy, University of Nottingham

  • MS in Chemistry, Loughborough University 

Affiliations and Professional Service

  • Royal Society of Chemistry  

  • American Institute of Physics  

  • UK Surface Analysis Forum 

  • Member, Editorial Board, Surface Science Spectra 

Publications

2019 

Angerer, T. B., N. Chakravarty, M. J. Taylor, C. D. Nicora, D. J. Graham, C. R. Anderton, E. H. Chudler, and L. J. Gamble. 2019. “Insights into the Histology of Planarian Flatworm Phagocata gracilis Based on Location Specific, Intact Lipid Information Provided by GCIB-ToF-SIMS Imaging.” Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1864 (5): 733-743. https://doi.org/10.1016/j.bbalip.2019.01.011https://doi.org/10.1016/j.bbalip.2019.01.011.  

Mecwan, M. M., M. J. Taylor, D. J. Graham, and B. D. Ratner. 2019. “Highly-Reactive Haloester Surface Initiators for ARGET ATRP Readily Prepared by Radio Frequency Glow Discharge Plasma.” Biointerphases 14 (4). https://doi.org/10.1116/1.5110163.  

Taylor, M. J., D. J. Graham, and L. J. Gamble. 2019. “Time-of-Flight Secondary Ion Mass Spectrometry Three-Dimensional Imaging of Surface Modifications in Poly(Caprolactone) Scaffold Pores.” Journal of Biomedical Materials Research - Part A 107 (10): 2195-2204. https://doi.org/10.1002/jbm.a.36729.  

2018 

Taylor, M. J., H. Aitchison, M. J. Hawker, M. N. Mann, E. R. Fisher, D. J. Graham, and L. J. Gamble. 2018. “Time of Flight Secondary Ion Mass Spectrometry - a Method to Evaluate Plasma-Modified Three-Dimensional Scaffold Chemistry.” Biointerphases 13 (3). https://doi.org/10.1116/1.5023005.  

Taylor, M. J., K. Y. Zhang, D. J. Graham, and L. J. Gamble. 2018. “Fatty Acid and Lipid Reference Spectra.” Surface Science Spectra 25 (2). https://doi.org/10.1116/1.5063595.  

2016 

Taylor, M., D. Scurr, M. Lutolf, L. Buttery, M. Zelzer, and M. Alexander. 2016. “3D Chemical Characterization of Frozen Hydrated Hydrogels Using ToF-SIMS with Argon Cluster Sputter Depth Profiling.” Biointerphases 11 (2): 1-7. https://doi.org/10.1116/1.4928209.