Interim EMSL Chief Science Officer
Interim EMSL Chief Science Officer

Biography

Christopher ("Chris") Anderton is the Interim Chief Science Officer for the Environmental Molecular Sciences Laboratory (EMSL), a Department of Energy (DOE) user facility. He will lead EMSL's strategic science planning and internal R&D initiatives.

Chris is a highly accomplished mass spectrometry imaging scientist whose creativity and innovative approaches have significantly advanced scientific capabilities in mass spectrometry (MS) imaging and functional understanding in tissues and systems. His work in spatial bioimaging and functional multi-omics mapping—supported by sponsors such as the DOE Office of Science's Biological and Environmental Research program and the National Institutes of Health—has showcased his deep commitment to driving impactful research and delivering transformative R&D innovations vital to the scientific mission of EMSL and our users.

Chris has an extensive background in elucidating chemical interactions occurring across all kingdoms of life, including those within soils and the rhizosphere. Through his graduate endeavors to his most recent positions, he focuses on the power of multimodal imaging methods to expand the type of information gained from samples. For his graduate work and postdoc at the National Institute of Standards and Technology, he used atomic force microscopy, scanning electron microscopy, and secondary ion mass spectrometry to understand the physicochemical properties of biological samples.

While at EMSL and Pacific Northwest National Laboratory (PNNL), his focus has been, in part, on expanding the mass spectrometry imaging capability—making these valuable tools for analyzing bacteria communities, rhizosphere-related systems, and even human health-related processes. He also focuses on visualizing the key mechanisms that drive interkingdom interactions within soil to understand the key drivers that lead to resiliency in the face of a changing environment.

Research Interest

  • Inter-Kingdom Interactions 
  • Spatial Metabolomics  
  • Mass Spectrometry Imaging 

Education

  • PhD in Analytical Chemistry, University of Illinois at Urbana-Champaign, 2010
  • BS in Chemistry, University of Colorado at Colorado Springs, 2005

Affiliations and Professional Service

  • Imaging Mass Spectrometry Society/International Mass Spectrometry Imaging Society – Americas 
    • President, 2025–2026
    • President-Elect, 2023–2024
    • Executive Committee Member, 2018–2022
  • American Society for Mass Spectrometry
    • Small Conference Committee Member, 2025–2026
    • Asilomar Committee Member, 2023–2025
    • Publications Committee Member, 2019–2021
  • Plant Cell Atlas
    • Metabolomics Committee Chair, 2020–2025 
  • Mass Spectrometry Imaging Society Member, 2017–Present
  • American Vacuum Society Member, 2011–Present
  • American Chemical Society Member, 2008–2014
  • Gamma Sigma Epsilon Chemical National Honor Society Member, 2003–Present

Publications

2025

  • K. Sharma, J. Hansen, K. Susztak, L. Eberlin, C. R. Anderton, T. Alexandrov, R. Iyengar, “Spatial metabolomics and multiomics integration for breakthroughs in precision medicine for kidney disease,” Nat Rev Nephrol 2025 DOI: 10.1038/s41581-025-01007-3
     
  • T. Zeng, X. Zheng, K. Zemaitis, D. Veličković, C. R. Anderton, “Integrating Ion Mobility Spectrometry and Mass Spectrometry Imaging for Characterizing the Distribution of Biologically Active Disaccharide Isomers,” JASMS 2025, 36, 1729 
     
  • D. Veličković, J. Purkerson, H. Bhotika, H. Huyck, G. Clair, G. S. Pryhuber, C. R. Anderton, “Integrating N-glycan and CODEX imaging reveal cell-specific protein glycosylation in healthy human lung,” Mol. Omics 2025, 21, 35 
     
  • D. Velickovic, C. R. Anderton, “Spatial Glycomics and Kidney Disease,” Semin Nephrology 2025, 44, 151581 
     
  • B.L. Gorman, C.C. Shafer, N. Ragi, K. Sharma, E. K. Neumann, C. R. Anderton, “Imaging and spatially resolved mass spectrometry applications in nephrology,” Nat Rev Nephrol 2025, 21, 399
     
  • D. Velickovic, M. Velickovic, C. L. O’Connor, M. Bitzer, C. R. Anderton, “The Impact of the Mass Analyzer and Tissue Section Thickness on Spatial N-Glycomics with MALDI-MSI,” J Am Soc Mass Spectrom 2025, 36, 823
     
  • C. R. Anderton, R G. Uhrig, “The promising role of proteomes and metabolomes in defining the single‐cell landscapes of plants,” New Phytol 2025, 245, 945
     
  • G. W. Vandergrift, M. Veličković, L. Z. Day, B. L. Gorman, S. M. Williams, B. Shrestha, C. R. Anderton, “Untargeted Spatial Metabolomics and Spatial Proteomics on the Same Tissue Section,” Anal Chem 2025, 97, 392

2024

  • J. L. DeYoung, U. G. Akporere, Z. Cheng, S. China, G. W. Vandergrift, C. R. Anderton, Y. Zhou, Z. Zhu, S. K. Shaw, “Chemical Differences in Environmental Films Collected on Surfaces with Different Hydrophilicity,” ACS Earth Space Chem. 2024, 8, 2411
     
  • G. W. Vandergrift, W. Kew, A. Andersen, J. K. Lukowski, Y. Goo, C. R. Anderton, “Experimental and Computational Evaluation of Lipidomic In-Source Fragmentation as a Result of Postionization with Matrix-Assisted Laser Desorption/Ionization,” Anal Chem 2024, 96, 16127
     
  • D. Veličković, T. Winkler, V. Balasubramanian, T. Wietsma, C. R. Anderton, A.H. Ahkami, K. Zemaitis, “RhizoMAP: a comprehensive, nondestructive, and sensitive platform for metabolic imaging of the rhizosphere,” Plant Methods 2024, 20, 117
     
  • A. Harrison, J. G. Eder, P. M. Lalli, N. Munoz, Y. Gao, C. S. Clendinen, D. J. Orton, X. Zheng, S. M. Williams, S. P. Couvillion, R. K. Chu, V. K. Balasubramanian, A. Bhattacharjee, C. R. Anderton, K. R. Pomraning, K. E. Burnum-Johnson, T. Liu, J. E. Kyle, A. Bilbao, “PeakQC: A Software Tool for Omics-Agnostic Automated Quality Control of Mass Spectrometry Data,” J Am Soc Mass Spectrom 2024, 35, 2680
     
  • D. Veličković, J. P. Shapiro, S. V. Parikh, B. Rovin, R. D. Toto, M. A. Vazquez, E. D. Poggio, J. F. O'Toole, J. R. Sedor, T. Alexandrov, S. Jain, M. Bitzer, J. Hodgin, M. Veličković, K. Sharma, C. R. Anderton, “Protein N-glycans in Healthy and Sclerotic Glomeruli in Diabetic Kidney Disease,” J Am Soc Nephro, 2024, 35, 1198.
     
  • V. K. Balasubramanian, D. Veličković, M. Wilhelmi, C. R. Anderton, C N. Stewart Jr, S. DiFazio, E. Blumwald, A. H. Ahkami, “Spatiotemporal metabolic responses to water deficit stress in distinct leaf cell-types of poplar,” Front Plant Sci 2024, 15, 1346853
     
  • B. L. Gorman, S. V. Torti, F. M. Torti, C. R. Anderton, “Mass spectrometry imaging of metals in tissues and cells: Methods and biological applications,” BBA Gen. Subjects 2024, 1868, 130329
     
  • D. Veličković, K.J. Zemaitis, A. Bhattacharjee, C.R. Anderton, “Mass spectrometry imaging of natural carbonyl products directly from agar-based microbial interactions using 4-APEBA derivatization,” mSystems 2024, 9, e00803
     
  • H. Kim, B. L. Gorman, M. J. Taylor, C. R. Anderton, “Atomistic simulations for investigation of substrate and salt effects on lipid in-source fragmentation in secondary ion mass spectrometry: A follow-up study,” Biointerphases 2024, 19, 011003

2023

  • B. L. Gorman, M. J. Taylor, L. Tesfay, J. K. Lukowski, P. Hegde, J. G. Eder, K. J. Bloodsworth, J. E. Kyle, S. Torti, C. R. Anderton, “Applying Multimodal Mass Spectrometry to Image Tumors Undergoing Ferroptosis Following In Vivo Treatment with a Ferroptosis Inducer,” JASMS 2023, 35, 5
     
  • W. L. King,  C. F. Yates,  L. Cao,  S. O'Rourke-Ibach,  S. M. Fleishman,  S. C. Richards,  M. Centinari,  B. D. Hafner,  M. Goebel,  T. Bauerle,  Y.-M. Kim,  C. D. Nicora,  C. R. Anderton,  D. M. Eissenstat,  T. H. Bell, “Functionally discrete fine roots differ in microbial assembly, microbial functional potential, and produced metabolites,” Plant Cell Environ., 46, 3919
     
  • A. Bhattacharjee, D. Velickovic, J. A. Richardson, S.P. Couvillion, G.W. Vandergrift, Q. Qafoku, M.J. Taylor, J.K. Jansson, K. Hofmockel, C.R. Anderton, “Fungal organic acid uptake of mineral-derived K is dependent on distance from carbon hotspot,” mBio 2023, 14, e00956-23
     
  • K. Sharma, G. Zhang, J. Hansen, [C. R. Anderton among 36 others], “Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients,” J Clin Investig 2023, 133, e170341
     
  • K. J. Zemaitis, V. S. Lin, A. H. Ahkami, T. E. Winkler, C. R. Anderton, D. Veličković, “Expanded Coverage of Phytocompounds by Mass Spectrometry Imaging Using On-Tissue Chemical Derivatization by 4-APEBA,” Anal Chem 2023, 95, 12701 
     
  • S. M. Yannarell, E. S. Beaudoin, H. S. Talley, A. A. Schoenborn, G. Orr, C. R. Anderton, W. B. Chrisler, E. A. Shank, “Extensive cellular multi-tasking within Bacillus subtilis biofilms,” mSystems 2023, 8, e00891
     
  • G. W. Vandergrift, K. J. Zemaitis, D. Veličković, J. K. Lukowski, L. Paša-Tolić, C. R. Anderton, W. Kew, “Experimental Assessment of Mammalian Lipidome Complexity Using Multimodal 21 T FTICR Mass Spectrometry Imaging,” Anal Chem 2023, 95, 10921
     
  • J.A. Richardson, C.R. Anderton, A. Bhattacharjee, “Saprotrophic Fungus Induces Microscale Mineral Weathering to Source Potassium in a Carbon-Limited Environment,” Minerals 2023, 13, 641
     
  • B. L. Gorman, S. V. Torti, F. M. Torti, C. R. Anderton, “Mass spectrometry imaging of metals in tissues and cells: Methods and biological applications,” Biochim Biophys Acta Gen Subj BBA-Gen Subjects 2023, 130329 
     
  • G. W. Vandergrift, J. K. Lukowski, M. J. Taylor, K. J. Zemaitis, T. Alexandrov, J. G. Eder, H. M. Olson, J. E. Kyle, C. R. Anderton, “Are Phosphatidic Acids Ubiquitous in Mammalian Tissues or Overemphasized in Mass Spectrometry Imaging Applications?,” Anal. Sens. 2023, e202200112
     
  • M. J. Taylor, H. Kim, W. Kew, A. Andersen, A. Bhattacharjee, M. H. Engelhard, C. R. Anderton, “Atomistic simulations for investigation of substrate effects on lipid in-source fragmentation in secondary ion mass spectrometry,” Biointerphases 2023, 18, 011003

2022

  • A. Bhattacharjee, O. Qafoku, J. A. Richardson, L. N. Anderson, K. Schwarz, L. M. Bramer, G. X. Lomas, D. J. Orton, Z. Zhu, M. H. Engelhard, M. E. Bowden, W. C Nelson, A. Jumpponen, J. K. Jansson, K. S. Hofmockel, C. R. Anderton, “A Mineral-Doped Micromodel Platform Demonstrates Fungal Bridging of Carbon Hot Spots and Hyphal Transport of Mineral-Derived Nutrients,” mSystems 2022, 7, e00913
     
  • K. T. Knizner, R. R. Kibbe, K. P. Garrard, J. R. Nuñez, C. R. Anderton, D. C. Muddiman, “On the importance of color in mass spectrometry imaging,” J Mass Spectrom 2022, 57, e4898
     
  • J. K Lukowski, H. Olson, M. Velickovic, [16 others], C. R. Anderton, “An optimized approach and inflation media for obtaining complimentary mass spectrometry-based omics data from human lung tissue,” Front Mol Biosci 2022, 9, 1022775
     
  • A. E. Donnelly, N. Narayanan, C. M.C. Birer-Williams, T. J. DeWolfe, R. K. Chu, C. R. Anderton, E. S Wright, “Balancing Trade-Offs Imposed by Growth Media and Mass Spectrometry for Bacterial Exometabolomics, Appl Environ Microbiol 2022, 88, e00922
     
  • D. Veličković, K. Sharma, T. Alexandrov, J. B. Hodgin, C. R. Anderton, “Controlled Humidity Levels for Fine Spatial Detail Information in Enzyme-Assisted N-Glycan MALDI MSI,” J Am Soc Mass Spectrom 2022, 33, 1577
     
  • J. Hansen, R. Sealfon, [C. R. Anderton among 41 others], E. U. Azeloglu, “A Reference Tissue Atlas for the Human Kidney,” Sci Adv 2022, 8, eabn4965
     
  • S. L. Rice, E. Lazarus, C.R. Anderton, K. Birnbaum, J. Brophy, B. Cole, D. Dickel, D. Ehrhardt, N. Fahlgren, M. Frank, E. Haswell, S. C. Huang, S. Leiboff, M. Libault, M. S. Otegui, N. Provart, R. G. Uhrig, S. Y. Rhee, “First Plant Cell Atlas symposium report,” Plant Direct 2022, 6, e406
     
  • A. A. Carrell, D. Veličković, T. J. Lawrence, B. P. Bowen, K. B. Louie, D. L. Carper, R. K. Chu, H. D. Mitchell, G. Orr, L. M. Markillie, S. S. Jawdy, J. Grimwood, A. J. Shaw, J. Schmutz, T. R Northen, C. R. Anderton, D. A. Pelletier, D. J. Weston, “Novel metabolic interactions and environmental conditions mediate the boreal peatmoss-cyanobacteria mutualism,” ISME 2022, 16, 1074
     
  • G. W. Vandergrift, W. Kew, J. K. Lukowski, A. Bhattacharjee, A. V. Liyu, E. A. Shank, L. Paša-Tolić, V. Prabhakaran, C. R. Anderton, “Imaging and Direct Sampling Capabilities of Nanospray Desorption Electrospray Ionization with Absorption-Mode 21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometry,” Anal Chem 2022, 94, 3629
     
  • L. K. Honeker, G. A. Hildebrand, J. D. Fudyma, L. E. Daber, D. Hoyt, S. E. Flowers, J. Gil-Loaiza, A. Kübert, I. Bamberger, C. R. Anderton, J. Cliff, S. Leichty, R. A. Tabrizi, J. Kreuzwieser, L. Shi, X. Bai, D. Velickovic, M. A. Dippold, S. N. Ladd, C. Werner, L. K. Meredith, M. M. Tfaily, “Elucidating Drought-Tolerance Mechanisms in Plant Roots through 1H NMR Metabolomics in Parallel with MALDI-MS, and NanoSIMS Imaging Techniques,” Environ Sci Technol 2022, 56, 2021
     
  • C. E. Chandler, C. R. Anderton, A. J. Scott, G. Charkoftaki, P. M. Angel, R. R. Drake, “Review of the Third Conference of the Imaging Mass Spectrometry Society: Accounts of a Hybrid Virtual and In-Person Meeting and the State and Future of the Field,” J Am Soc Mass Spectrom 2022, 33, 238

2021

  • L. Z. Samarah, A. Vertes, C.R. Anderton, “Single-Cell Metabolomics with Rapid Determination of Chemical Formulas from Isotopic Fine Structures,” Mass Spectrometry Imaging of Small Molecules 2021 (Book), 61
     
  • D. Velickovic, T. Bečejac, S. Mamedov, K. Sharma, N. Ambalavanan, T. Alexandrov, C. R. Anderton, “Rapid Automated Annotation and Analysis of N-Glycan Mass Spectrometry Imaging Data Sets Using NGlycDB in METASPACE,” Anal Chem 2021, 40, 13421
     
  • S.M. Yannarell, D. Veličković, C.R. Anderton, E.A. Shank, “Direct Visualization of Chemical Cues and Cellular Phenotypes throughout Bacillus subtilis Biofilms,” mSystems 2021, 6, e01038-21
     
  • S. G. Jha, A. T. Borowsky, [C. R. Anderton among over 50 others], Plant Cell Atlas Consortium, “Science Forum: Vision, challenges and opportunities for a Plant Cell Atlas”, eLife 2021, 10, e66877 
     
  • J. K Lukowski, A. Bhattacharjee, S. M. Yannarell, K. Schwarz, L. M. Shor, E. A. Shank, C. R. Anderton, “Expanding Molecular Coverage in Mass Spectrometry Imaging of Microbial Systems Using Metal-Assisted Laser Desorption/Ionization,” Microbio Spectrum 2021, 1, e00520
     
  • C.M.C. Birer-Williams, R. K. Chu, C. R. Anderton, E.S. Wright, “SubTap, a Versatile 3D Printed Platform for Eavesdropping on Extracellular Interactions,” mSystems 2021, 6, e00902
     
  • M.J. Taylor, A. Liyu, A. Vertes, C. R. Anderton, “Ambient single-cell analysis and native tissue imaging using laser-ablation electrospray ionization mass spectrometry with increased spatial resolution,” J Am Soc Mass Spectrom 2021, 32, 2490
     
  • F. Khalaj, A. Rivas-Ubach, C. R. Anderton, S. China, K. Mooney, C. L. Faiola, “Acyclic terpenes reduce secondary organic aerosol formation from emissions of a riparian shrub,” ACS Earth and Space Chemistry 2021, 5, 1242
     
  • R. A. Lybrand, D. P Veghte, S. China, D. G. Zaharescu, C. R. Anderton, R. Aleman, P. A. Schroeder, O. Qafoku, “Deciphering the Incipient Phases of Ice–Mineral Interactions as a Precursor of Physical Weathering, ACS Earth and Space Chemistry 2021, 5, 1233
     
  • M. J. Taylor, S. Mattson, A. Liyu, S. A Stopka, Y. M. Ibrahim, A. Vertes, C. R. Anderton, “Optical Microscopy-Guided Laser Ablation Electrospray Ionization Ion Mobility Mass Spectrometry: Ambient Single Cell Metabolomics with Increased Confidence in Molecular Identification”, Metabolites 2021, 11, 200
     
  • M. J. Taylor, J. K. Lukowski, C.R. Anderton, “Spatially resolved mass spectrometry at the single cell: recent innovations in proteomics and metabolomics,” J Am Soc Mass Spectrom 2021, 32, 872
     
  • K.R. Tuttle, J. Bebiak, [C.R. Anderton among over 50 other authors], “Patient perspectives and involvement in precision medicine research,” Kidney Inter 2021, 99, 511
     
  • I.H. de Boer, C.E. Alpers, [C.R. Anderton among over 50 other authors], “Rationale and design of the kidney precision medicine project,” Kidney Inter 2021, 99, 498
     
  • E. K. Zegeye, N. C. Sadler, G. X. Lomas, I. K. Attah, J. K. Jansson, K. S. Hofmockel, C. R. Anderton, A. T. Wright, “Activity‐Based Protein Profiling of Chitin Catabolism,” ChemBioChem 2021, 6, 717
     
  • D. Veličković, R. K Chu, C. Henkel, A. Nyhuis, N. Tao, J. E. Kyle, J. N. Adkins, C. R. Anderton, V. Paurus, K. Bloodsworth, L. M. Bramer, D. S. Cornett, W. R. Curtis, K. E. Burnum‐Johnson, “Preserved and variable spatial‐chemical changes of lipids across tomato leaves in response to central vein wounding reveals potential origin of linolenic acid in signal transduction cascade,” Plant-Env Inter 2021, 2, 28
     
  • A. Bhattacharjee, L. N. Anderson, T. Alfaro, A. Porras-Alfaro, A. Jumpponen, K. S. Hofmockel, J. K. Jansson, C.R. Anderton, W. C, Nelson, Micro Res Announc 2021, 10, e00884
     
  • N.B. Waldo, M.M. Tfaily, C R. Anderton, R.B. Neumann, “The importance of nutrients for microbial priming in a bog rhizosphere,” Biogeochem 2021, 152, 271
     
  • T. M. El-Achkar, M. T. Eadon, [C.R. Anderton among 36 others], S. Jain, “A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project,” Physio Genomics 2021, 53, 1

2020

  • A. Bhattacharjee, A. M. Thompson, K. C. Schwarz, M. C. Burnet, Y.-M. Kim, J. R. Nunez, S. J. Fansler, Y. F., C. J. Brislawn, T. O. Metz, R. S. McClure, R. S. Renslow, L. Shor, J. K. Jansson, K. S. Hofmockel, C. R. Anderton, “Soil microbial EPS resiliency is influenced by carbon source accessibility,” Soil Bio Biochem 2020, 151, 108037
     
  • J. K. Lukowski, A. Pamreddy, D. Velickovic, G. Zhang, L. Pasa-Tolic, T. Alexandrov, K. Sharma, C. R. Anderton, Storage conditions of human kidney tissue sections affect spatial Lipidomics analysis reproducibility,” J Am Soc Mass Spectrom, 2020, 31, 2538
     
  • E. Ong, L. L. Wang, [C. R Anderton among 23 others], Y. He, “Modelling kidney disease using ontology: insights from the Kidney Precision Medicine Project”, Nat Rev Nerphrology 2020, 11, 686
     
  • C. R. Anderton, J. M. Mobberley, J. K. Cole, J. R. Nunez, R. Starke, A. A. Boaro, Y. Yesiltepe, B. R. Morton, A. B. Cory, H. C. Cardamone, K. S. Hofmockel, M. S. Lipton, J. J. Moran, R. S. Renslow, J. K. Fredrickson, S. R. Lindemann, “Nitrogen Source Governs Community Carbon Metabolism in a Model Hypersaline Benthic Phototrophic Biofilm,” mSystems 2020, 5, e00260
     
  • D. Naylor, N. Sadler, A. Bhattacharjee, E. B. Graham, C. R. Anderton, R. McClure, M. Lipton, K. S. Hofmockel, J. K. Jansson, “Soil Microbiomes Under Climate Change and Implications for Carbon Cycling,” Annu. Rev. Environ. Resour. 2020, 45, 29
     
  • J.-Y. Lee, N. C.Sadler, R. G.Egbert, C. R. Anderton, K. S. Hofmockel, J. K.Jansson, H.-S. Song, “Deep learning predicts microbial interactions from self-organized spatiotemporal patterns,” Comput. Struct. Biotec. 2020, 18, 1259
     
  • B. J. Agtuca, S. A. Stopka, S. Evans, L. Samarah, Y. Liu, D. Xu, M. G. Stacey, D. W. Koppenaal, L. Paša‐Tolić, C. R. Anderton, A. Vertes, G. Stacey, “Metabolomic profiling of wild‐type and mutant soybean root nodules using laser‐ablation electrospray ionization mass spectrometry reveals altered metabolism,” Plant  J. 2020, 103, 1937
     
  • L. Z. Samarah, R. Khattar, T. H. Tran, S. A. Stopka, C. A. Brantner, P. Parlanti, D. Veličković, J. B. Shaw, B. J. Agtuca, G. Stacey, L. Paša-Tolić, N. Tolić, C. R. Anderton, A. Vertes, “Single-Cell Metabolic Profiling: Metabolite Formulas from Isotopic Fine Structures in Heterogeneous Plant Cell Populations,” Anal. Chem. 2020, 92, 7289
     
  • L. Krounbi, A. Enders, C. R. Anderton, M. H. Engelhard, R. Hestrin, D. Torres-Rojas, J. J. Dynes, J. Lehmann, “Sequential Ammonia and Carbon Dioxide Adsorption on Pyrolyzed Biomass to Recover Waste Stream Nutrients,” ACS Sustainable Chem. Eng. 2020, 8, 7121
     
  • D. Veličković, V. S. Lin, A. Rivas, C. R. Anderton, J. J. Moran, “An approach for broad molecular imaging of the root-soil interface via indirect matrix-assisted laser desorption/ionization mass spectrometry,” Soil Bio Biochem 2020, 146, 107804
     
  • D. Veličković, G. Zhang, D. Bezbradica, A. Bhattacharjee, L. Paša-Tolić, K. Sharma, T. Alexandrov, C. R. Anderton, “Response Surface Methodology as a New Approach for Finding Optimal MALDI Matrix Spraying Parameters for MSI,” J Am Soc Mass Spectrom, 2020, 31, 508
     
  • A. Bhattacharjee, D. Velickovic, T.W. Wietsma, S. L. Bell, J.K. Jansson, K.S. Hofmockel, C. R. Anderton, “Visualizing Microbial Community Dynamics via a Controllable Soil Environment,” mSystems 2020, 5, e00645
     
  • G. Zhang, J. Zhang, R. DeHoog, S. Pennathur, C. R. Anderton, M. Venkatachalam, T. Alexandrov, L. S. Eberlin, K. Sharma, “DESI MSI and METASPACE indicates lipid abnormalities and altered mitochondrial membrane components in diabetic renal proximal tubules,” Metabol. 2020, 16, 11
     
  • D. Veličković, R. K. Chu, G. L. Myers, A. H. Ahkami, C. R. Anderton, “An approach for visualizing the spatial metabolome of an entire plant root system inspired by the Swiss‐rolling technique,” J. Mass Spec. 2020, 55, e4363 
     
  • B. Agtuca, S. A. Stopka, T. R. Tuleski, F. Plucani do Amaral, S. Evans, Y. Liu, D. Xu, R. A. Monteiro, D. W. Koppenaal, L. Paša-Tolić, C. R. Anderton, A. Vertes, G. Stacey, “In situ metabolomic analysis of Setaria viridis roots colonized by beneficial endophytic bacteria”, Mol. Plant-Micro. Interact. 2020, 33, 272 

2019

  • J. S. Grant, P. M. Richards, C. R. Anderton, Z. Zhu, T. E. Mattes, S. K. Shaw, “Passively Sampled Environmental Films Show Geographic Variability and Host a Variety of Microorganisms,” ACS Earth and Space Chemistry 2019, 3, 2726
     
  • T. B. Angerer, D. Veličković, C. D. Nicora, J. E. Kyle, D. J. Graham, C. R. Anderton, L. J. Gamble, “Exploiting the Semidestructive Nature of Gas Cluster Ion Beam Time-of-Flight Secondary Ion Mass Spectrometry Imaging for Simultaneous Localization and Confident Lipid Annotations,” Anal. Chem. 2019, 91, 23, 15073
     
  • D. Veličković, H. L. Liao, R. Vilgalys, R. K. Chu, C. R. Anderton, “Spatiotemporal transformation in the alkaloid profile of Pinus roots in response to mycorrhization,” J Nat Prod 2019, 82, 1386
     
  • S. A. Stopka, L. Samarah, J. B. Shaw, A. Liyu, D. Veličković, B. J. Agtuca, D. Koppenaal, G. Stacey, L. Paša-Tolić, C. R. Anderton, A. Vertes, “Ambient Metabolic Profiling and Imaging of Biological Samples with Ultrahigh Molecular Resolution using Laser Ablation Electrospray Ionization 21T-FTICR Mass Spectrometry,” Anal Chem 2019, 91, 5028
     
  • T. B. Angerer, N. Chakravarty, M. J. Taylor, C. D. Nicora, D. J. Graham, C. R. Anderton, E. H. Chudler, L J. Gamble, “Insights into the histology of planarian flatworm Phagocata gracilis based on location specific, intact lipid information provided by GCIB-ToF-SIMS imaging,” BBA - Molecular and Cell Biology of Lipids 2019, 1864, 733
     
  • J. S. Grant, Z. Zhu, C. R. Anderton, S. K. Shaw, “Physical and Chemical Morphology of Passively Sampled Environmental Films,”ACS Earth and Space Chemistry 2019, 3, 305
     
  • G. Nagy, D. Veličković, R. K. Chu, A. A. Carrell, D. J. Weston, Y. M. Ibrahim, C. R. Anderton, R. D. Smith, “Towards resolving the spatial metabolome with unambiguous molecular annotations in complex biological systems by coupling mass spectrometry imaging with structures for lossless ion manipulations,” Chem. Commun. 2019, 55, 306

2018

  • S.A. Stopka, R. Khattar, B. J. Agtuca, C. R. Anderton, L. Paša-Tolić, G. Stacey, A. Vertes, “Metabolic Noise and Distinct Subpopulations Observed by Single Cell LAESI Mass Spectrometry of Plant Cells in situ,” Front Plant Sci. 2018, 9, 1646
     
  • J. R. Nuñez, C. R. Anderton, R. S. Renslow, “An optimized colormap for the scientific community,” PLoS One 2018, 13, e0199239
     
  • D. Veličković, B. Agtuca, S. A. Stopka, A. Vertes, D. W. Koppenaal, L. Paša-Tolić, G. Stacey, C. R. Anderton, “Visualization of soybean nodule metabolism by high-resolution molecular tomography,” ISME 2018, 12, 2335
     
  • J. R. Nuñez, R.S. Renslow, J.B. Cliff, C.R. Anderton, “NanoSIMS for Biological Applications: Current Practices and Analyses,” Biointerphases 2018, 13, 03B301

2017

  • D. Veličković, R. K. Chu, A. A. Carrell, M. Thomas, L. Paša-Tolić, D. J. Weston, C. R. Anderton, “Multimodal MSI in Conjunction with Broad Coverage Spatially Resolved MS2 Increases Confidence in Both Molecular Identification and Localization,” Anal Chem 2017, 90, 702
     
  • S.A. Stopka, B.J. Agtuca, D.W. Koppenaal, L. Paša-Tolić, G. Stacey, A. Vertes, C.R. Anderton, “Laser Ablation Electrospray Ionization Mass Spectrometry with Ion Mobility Separation Reveals Metabolites in the Symbiotic Interactions of Soybean Roots and Rhizobia,” Plant J 2017, 91, 34
     
  • D. Veličković, C. R. Anderton, “Mass spectrometry imaging: Towards mapping the elemental and molecular composition of the rhizosphere,” Rhizosphere 2017, 3, 254 
     
  • S.N. Nguyen, A.V. Liyu, R.K. Chu, C.R. Anderton, J. Laskin, "Constant Distance Mode Nanospray Desorption Electrospray Ionization Mass Spectrometry Imaging of Biological Samples of Complex Topography," Anal Chem 2017, 89, 1131

2016

  • C. R. Anderton, “Mass Spectrometry Imaging and Applications,” Encyclopedia of Spectroscopy and Spectrometry, 3rd edition, 2016
     
  • M. T. Proetto, C. R. Anderton, D. Hu, C. J. Szymanski, Z. Zhu, J. P. Patterson, A. M. Rush, N. C. Bell, J. Kammeyer, J. Evans, G. Orr, S. B. Howell, N. C. Gianneschi, “Cellular Delivery of Nanoparticles Revealed with Combined Optical and Isotopic Nanoscopy," ACS Nano 2016, 10, 4046
     
  • R.S. Renslow, S.R. Lindemann, J.K. Cole, Z. Zhu, C.R. Anderton, "Quantifying Element Incorporation In Multispecies Biofilms Using Nanoscale Secondary Ion Mass Spectrometry Image Analysis," Biointerphases 2016, 11, 02A322
     
  • C.R. Anderton, L.J. Gamble, "Secondary Ion Mass Spectrometry Imaging of Tissues, Cells, and Microbial Systems," Microscopy Today 2016, 24, 24
     
  • C.R. Anderton, R.K. Chu, N. Tolic, A.V. Creissen, L Pasa-Tolic, "Utilizing a Robotic Sprayer for High Lateral and Mass Resolution MALDI FT-ICR MSI of Microbial Cultures," J Am Soc Mass Spectrom, 2016, 27, 556

2015

  • M. M. Tfaily, R. K. Chu, N. Tolić, K. M. Roscioli, B. Anderson, C. R. Anderton, L. Paša-Tolić, E. Robinson, N. J. Hess, “Advanced Solvent Based Methods for Molecular Characterization Of Soil Organic Matter By High-Resolution Mass Spectrometry,” Anal Chem 2015, 87, 5206
     
  • J. M. Troiano, L. L. Olenick, T. R. Kuech, E. S. Melby, D. Hu, S. E. Lohse, A. C. Mensch, M. Dogangun, A. M. Vartanian, M. Torelli, E. Ehimiaghe, S. R. Walter, L. Fu, C. R. Anderton, Z. Zhu, H. Wang, G. Orr, C. J. Murphy, R. J. Hamers, J. A. Pedersen, F. M. Geiger, “Direct Probes Of 4-nm Diameter Gold Nanoparticles Interacting With Supported Lipid Bilayers,” J Phys Chem C 2015, 119, 534
     
  • J. D. DeBord, D. F. Smith, C. R. Anderton, R. M. A. Heeren, L. Paša-Tolić, R. H. Gomer, F. A. Fernandez-Lima, “Secondary Ion Mass Spectrometry Imaging of Dictyostelium discoideum Aggregation Streams,” PLoS one 2014, 9, e99319
     
  • K.H. Chung, A. K. Chen, C. R. Anderton, K. Bhadriraju, A. L. Plant, B.G. Bush, R.F. Cook, F. W. DelRio, “Frictional Properties Of Native And Functionalized Type I Collagen Thin Films,” Appl. Phys. Lett. 2013, 103, 143703
     
  • C. R. Anderton, F. W. DelRio, K. Bhadriraju, A. L. Plant, “The effect of high vacuum on the mechanical properties and bioactivity of collagen fibril matrices,” Biointerphases 2013, 8, 2
     
  • C. R. Anderton, B. Vaezian, K. Lou, J. F. Frisz, M. L. Kraft, “Identification of a Lipid-Related Peak Set to Enhance the Interpretation of TOF-SIMS Data from Model and Cellular Membranes,” Surf. Interface. Anal. 2012, 44, 322
     
  • C. R. Anderton, K. Lou, P. K. Weber, I. D. Hutcheon, M. L. Kraft, “Correlated AFM and NanoSIMS Imaging to Probe Cholesterol-Induced Changes in Phase Behavior and Non-Ideal Mixing in Ternary Lipid Membranes,” BBA-Biomembranes 2011, 1808, 307
     
  • B. Vaezian, C. R. Anderton, M.L. Kraft, "Discriminating and Imaging Different Phosphatidylcholine Species within Phase-Separated Model Membranes by Principal Component Analysis of TOF-SIMS Spectral Images,” Anal. Chem. 2010, 82, 10006
     
  • M. E. Stewart, C. R. Anderton, L. B. Thompson, J. Maria, S. K. Gray, J. A. Rogers, R. G. Nuzzo, “Nanostructured Plasmonic Sensors,” Chem. Rev. 2008, 108, 494
     
  • D. J. Weiss, E. J. Austria, C. R. Anderton, R. Hompesch, A. Jander, “Analysis of Green Tea Extract Dietary Supplements using Micellar Electrokinetic Chromatography,” J. Chromatogr. A. 2006, 1117, 103
     
  • D. J. Weiss and C. R. Anderton, "Determination of Catechins in Matcha Green Tea by Micellar Electrokinetic Chromatography," J. Chromatogr. A. 2003, 1011, 173