PNNL

Brittney Gorman is a postdoctorate RA researching the spatial lipidomics involved in human health with the Biogeochemical Transformation team. Her work includes the integration of matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) with other imaging modalities including secondary ion mass spectrometry and fluorescence microscopy. Through her participation in the Kidney Precision Medicine Project, LungMAP, and the Human BioMolecular Atlas Program (HuBMAP), she has applied these approaches to investigate the spatial lipidomics and metabolomics in the kidneys and lungs and track changes that occur during disease.

• MALDI mass spectrometry
• Secondary ion mass spectrometry
• Fluorescence microscopy
• Lipidomics

• PhD in biophysics, University of Illinois Urbana-Champaign, 2021
• BA in biomedical physics, Lipscomb University, 2016

• American Chemical Society, 2012–present
• American Society for Mass Spectrometry, 2022–present
• Biophysical Society, 2018–present
• Females in Mass Spectrometry, 2023–present

• Southeast Regional Lipid Conference Presentation Award, 2021
• National Science Foundation Graduate Research Fellowships Program, Honorable Mention, 2018

2025

• Gorman B.L., C.C. Shafer, N. Ragi, K. Sharma, E.K. Neumann, and C.R. Anderton. 2025. "Imaging and Spatially Resolved Mass Spectrometry Applications in Nephrology." Nature Reviews Nephrology 21, no. 6:399-416. PNNL-SA-206921. doi:10.1038/s41581-025-00946-1
• Vandergrift G.W., M. Velickovic, L.Z. Day, B.L. Gorman, S.M. Williams, B. Shrestha, and C.R. Anderton. 2025. "Untargeted Spatial Metabolomics and Spatial Proteomics on the Same Tissue Section." Analytical Chemistry 97, no. 1:392-400. PNNL-SA-202874. doi:10.1021/acs.analchem.4c04462

2024

• Gorman B.L., and J.K. Lukowski. 2024. "Spatial metabolomics and lipidomics in kidney disease." Seminars in Nephrology 44, no. 6:Art. No. 151582. PNNL-SA-207560. doi:10.1016/j.semnephrol.2025.151582
• Gorman B.L., M.J. Taylor, L. Tesfay, J.K. Lukowski, P.U. Hegde, J.G. Eder, and K.J. Bloodsworth, et al. 2024. "Applying Multimodal Mass Spectrometry to Image Tumors Undergoing Ferroptosis Following In Vivo Treatment with a Ferroptosis Inducer." Journal of the American Society for Mass Spectrometry 35, no. 1:5-12. PNNL-SA-185527. doi:10.1021/jasms.3c00193
• Kim H., B.L. Gorman, M.J. Taylor, and C.R. Anderton. 2024. "Atomistic Simulations for Investigation of Substrate and Salt Effects on Lipid In-Source Fragmentation in Secondary Ion Mass Spectrometry: A Follow-Up Study." Biointerphases 19, no. 1:Art. No. 011003. PNNL-SA-192467. doi:10.1116/6.0003281

2023

• Gorman et al. 2023. "Mass spectrometry imaging of metals in tissues and cells: Methods and biological applications." Biochimica et Biophysica Acta (BBA) - General Subjects.  DOI: 10.1016/j.bbagen.2023.130329

2022

• Brunet et al. 2022. "Depth Correction of 3D NanoSIMS Images Shows Intracellular Lipid and Cholesterol Distributions while Capturing the Effects of Differential Sputter Rate." ACS Nano. DOI: 10.1021/acsnano.2c05148

2021

• Gorman et al. 2021. "Depth correction of 3D NanoSIMS images using secondary electron pixel intensities." Biointerphases 16, 041005 (2021) DOI: 10.1116/6.0001092

2020

• Patrana-Otero et al. 2020. "Development of an inexpensive Raman-compatible substrate for the construction of a microarray screening platform."  Analyst 21. DOI: 10.1039/D0AN01153C