PNNL

Angela Norbeck is a data scientist, project manager, and line manager in the Physical and Computational Sciences Directorate (PCSD). She has been at PNNL since 2004, starting in the proteomics group in EMSL, the Environmental Molecular Sciences Laboratory, and transitioning into the National Security Directorate before joining PCSD in 2019. She has a background in data workflow development, data analysis, integration of high-performance computing (HPC) into workflows, and databases. She currently manages projects involved in national security, cybersecurity, and software development supporting molecular chemistry. She also manages the Computational and Data Engineering group, which includes three teams of researchers in mathematics, materials science, software engineering, and data architectures. 

Norbeck draws from her years of experience in biological data analysis and data sciences to explore solutions in biosecurity, cybersecurity, and computing. Specific areas of focus in computing include data integration, big data management, using HPC for performance optimization, and user interfaces with intelligent controls and monitoring.

• Biological Databases
• Biological Threat Prediction
• Cybersecurity
• Data Analysis
• Information Resources Management
• Proteomics
• SQL Server Integration Services (SSIS)
• Workflow Applications

MISM, Business Systems, Walden University (2012)

BS, Chemical Oceanography, University of Washington (2000)

Project Management Professional, Project Management Institute (2018–present)

Outstanding Performance Award, PNNL (2005, 2010, 2012)

EMSL Director’s Award in Collaboration, PNNL (2012)

“BCLUSTER” IP ID No. 31254-E, September 2017

2021

• Hagen L., C.G. Brooke, C.A. Shaw, A.D. Norbeck, H. Piao, M.Ø. Arntzen, and H.M. Olson, et al. 2021. "Proteome specialization of anaerobic fungi during ruminal degradation of recalcitrant plant fiber." The ISME Journal 15, no. 2:421-434. PNNL-SA-160712. doi:10.1038/s41396-020-00769-x

2018

• Naas A., L. Solden, A.D. Norbeck, H.M. Brewer, L. Hagen, I. Heggenes, and A. Mchardy, et al. 2018. "“Candidatus Paraporphyromonas polyenzymogenes” encodes multi-modular cellulases linked to the type IX secretion system." Microbiome 6. PNNL-SA-129531. doi:10.1186/s40168-018-0421-8

2017

• Hawely A.K., M. Torres Beltran, E. Zaikova, D.A. Walsh, A. Mueller, M. Scofield, and S. Kheirandish, et al. 2017. "A compendium of multi-omic sequence information from the Saanich Inlet water column." Scientific Data 4. PNNL-SA-121885. doi:10.1038/sdata.2017.160
• Staley C., A.P. Ferrieri, M.M. Tfaily, Y. Cui, R.K. Chu, P. Wang, and J.B. Shaw, et al. 2017. "Diurnal Cycling of Rhizosphere Bacterial Communities is Associated with Shifts in Carbon Metabolism." Microbiome 5. PNNL-SA 121718. doi:10.1186/s40168-017-0287-1

2016

• Smith D., C.D. Nicora, P. Carini, M.S. Lipton, A.D. Norbeck, R.D. Smith, and S.J. Giovannoni. 2016. "Proteome Remodeling in Response to Sulfur Limitation in “Candidatus Pelagibacter ubique” mSystems 1, no. 4: e00068-16. PNNL-SA-113512. doi:10.1128/mSystems.00068-16

2015

• Ream T.S., J.R. Haag, F. Pontvianne, C.D. Nicora, A.D. Norbeck, L. Pasa-Tolic, and C.S. Pikaard. 2015. "Subunit compositions of Arabidopsis RNA polymerases I and III reveal Pol I- and Pol III- specific forms of the AC40 subunit, and alternative C53 subunits." Nucleic Acids Research 43, no. 8:4163–4178. PNNL-SA-108415. doi:10.1093/nar/gkv247

2014

• Haag J.R., B. Brower-Toland, E.K. Krieger, L. Sidorenko, C.D. Nicora, A.D. Norbeck, and A. Irsigler, et al. 2014. "Functional Diversification of Maize RNA Polymerase IV and V subtypes via Alternative Catalytic Subunits." Cell Reports 9, no. 1:378–390. PNNL-SA-105690. doi:10.1016/j.celrep.2014.08.067
• Hawley A.K., H.M. Brewer, A.D. Norbeck, L. Pasa-Tolic, and S.J. Hallam. 2014. "Metaproteomics reveals differential modes of metabolic coupling among ubiquitous oxygen minimum zone microbes." Proceedings of the National Academy of Sciences of the United States of America 111, no. 31:11395–11400. PNNL-SA-100391. doi:10.1073/pnas.1322132111

2013

• DeAngelis K.M., D. Sharma, R. Varney, B.A. Simmons, N.G. Isern, L.M. Markillie, and C.D. Nicora, et al. 2013. "Evidence supporting dissimilatory and assimilatory lignin degradation in Enterobacter lignolyticus SCF1." Frontiers in Microbiology 4. PNNL-SA-96504.
• Hawley A.K., S. Kheirandish, A. Mueller, H.C. Leung, A.D. Norbeck, H.M. Brewer, and L. Pasa-Tolic, et al. 2013. "Molecular Tools for Investigating Microbial Community Structure and Function in Oxygen-Deficient Marine Waters." In Methods in Enzymology: Microbial Metagenomics, Metatranscriptomics, and Metaproteomics, edited by EF DeLong. 305–329. San Diego, California: Academic Press. PNNL-SA-100374.
• Nicora C.D., B.J. Anderson, S.J. Callister, A.D. Norbeck, S.O. Purvine, J.K. Jansson, and O.U. Mason, et al. 2013. "Amino acid treatment enhances protein recovery from sediment and soils for metaproteomic studies." Proteomics 13, no. 18-19:2776–2785. PNNL-SA-92783. doi:10.1002/pmic.201300003

2012

• Haag J.R., T.S. Ream, M. Marasco, C.D. Nicora, A.D. Norbeck, L. Pasa-Tolic, and C.S. Pikaard. 2012. "In vitro transcription activities of Pol IV, Pol V and RDR2 reveal coupling of Pol IV and RDR2 for dsRNA synthesis in plant RNA silencing." Molecular Cell 48, no. 5:811–818. PNNL-SA-90501. doi:10.1016/j.molcel.2012.09.027
• Rutledge A.C., G. Fontes, M.A. Gritsenko, A.D. Norbeck, D.J. Anderson, K.M. Waters, and J.N. Adkins, et al. 2012. "Discovery of novel glucose-regulated proteins in isolated human pancreatic islets using LC-MS/MS-based proteomics." Journal of Proteome Research 11, no. 7:3520-2532. PNNL-SA-77193. doi:10.1021/pr3002996

2011

• Hallam S.J., A.P. Page, L. Constan, Y.C. Song, A.D. Norbeck, H.M. Brewer, and L. Pasa-Tolic. 2011. "Molecular tools for investigating ANME community structure and function." In Methods in Enzymology, Part A, edited by AC Rosenzweig and SW Ragsdale. 75–90. Amsterdam:Elsevier/Academic Press. PNNL-SA-75404.
• Lin M., T. Kikuchi, H.M. Brewer, A.D. Norbeck, and Y. Rikihisa. 2011. "Global proteomic analysis of two tick-borne emerging zoonotic agents: Anaplasma phagocytophilum and Ehrlichia chaffeensis." Frontiers in Microbiology 2. PNNL-SA-77990. doi:10.3389/fmicb.2011.00024

2010

• Sigdel T.K., A. Kaushal, M.A. Gritsenko, A.D. Norbeck, W. Qian, W. Xiao, and D.G. Camp, et al. 2010. "Shotgun Proteomics Identifies Proteins Specific for Acute Renal Transplant Rejection." Proteomics - Clinical Applications 4, no. 1:32–47. PNNL-SA-68069. doi:10.1002/prca.200900124
• Smith D.P., J.B. Kitner, A.D. Norbeck, T.R. Clauss, M.S. Lipton, M.S. Schwalbach, and L. Steindler, et al. 2010. "Transcriptional and translational regulatory responses to iron limitation in the globally distributed marine bacterium Candidatus Pelagibacter ubique." PLoS One 5, no. 5: Article Number: e10487. PNNL-SA-72424.

2009

• Chowdhury S.M., L. Shi, H. Yoon, C. Ansong, L.M. Rommereim, A.D. Norbeck, and K.J. Auberry, et al. 2009. "A method for investigating protein-protein interactions related to Salmonella typhimurium pathogenesis." Journal of Proteome Research 8, no. 3:1504–1514. PNNL-SA-58873.
• Ream T.S., J.R. Haag, A.T. Wierzbicki, C.D. Nicora, A.D. Norbeck, J. Zhu, and G. Hagen, et al. 2009. "Subunit Compositions of the RNA-Silencing Enzymes Pol IV and Pol V Reveal Their Origins as Specialized Forms of RNA Polymerase II." Molecular Cell 33, no. 2:192–203. PNNL-SA-75446. doi:10.1016/j.molcel.2008.12.015
• Ream T.S., J.R. Haag, A.T. Wierzbicki, C.D. Nicora, A.D. Norbeck, J.K. Zhu, and G. Hagen, et al. 2009. "Subunit Compositions of the RNA-Silencing Enzymes Pol IV and Pol V Reveal Their Origins as Specialized Forms of RNA Polymerase II." Molecular Cell 33, no. 2:192–203. PNNL-SA-62481. doi:doi:10.1016/j.molcel.2008.12.015
• Shi L., C. Ansong, H.S. Smallwood, L.M. Rommereim, J.E. McDermott, H.M. Brewer, and A.D. Norbeck, et al. 2009. "Proteome of Salmonella enterica serotype Tyhimurium Grown in Low Mg2+/pH Medium." Journal of Proteomics and Bioinformatics 2, no. 9:388–397. PNNL-SA-68770. doi:10.4172/jpb.1000099
• Shi L., C. Ansong, H.S. Smallwood, L.M. Rommereim, J.E. McDermott, H.M. Brewer, and A.D. Norbeck, et al. 2009. "Proteome of Salmonella Enterica SerotypeTyphimurium Grown in a Low Mg2+/pH Medium." Journal of Proteomics and Bioinformatics 2, no. 9:388–397. PNNL-SA-60692. doi:10.4172/jpb.1000099
• Shi L., S.M. Chowdhury, H.S. Smallwood, H. Yoon, H.M. Mottaz-Brewer, A.D. Norbeck, and J.E. McDermott, et al. 2009. "Proteomic Investigation of the Time Course Responses of RAW 264.7 Macrophages to Infection with Salmonella enterica." Infection and Immunity 77, no. 8:3227–3233. PNNL-SA-62432. doi:10.1128/IAI.00063-09
• Sowell S.M., L. Wilhelm, A.D. Norbeck, M.S. Lipton, C.D. Nicora, D.F. Barofsky, and C. carlson, et al. 2009. "Transport Functions Dominate the SAR11 Metaproteome at Low-Nutrient Extremes in the Sargasso Sea." The ISME Journal 3, no. 1:93-105. PNNL-SA-60995.
• Yang F., S. Wu, D.L. Stenoien, R. Zhao, M.E. Monroe, M.A. Gritsenko, and S.O. Purvine, et al. 2009. "Combined Pulsed-Q dissociation and electron transfer dissociation for identification and quantitation of iTRAQ-labeled phosphopeptides." Analytical Chemistry 81, no. 10:4137–4143. PNNL-SA-63701. doi:10.1021/ac802605m
• Zhou J., B.O. Petritis, K. Petritis, A.D. Norbeck, K.K. Weitz, R.J. Moore, and D.G. Camp, et al. 2009. "Mouse-Specific Tandem IgY7-SuperMix Immunoaffinity Separations for Improved LC-MS/MS Coverage of the Plasma Proteome." Journal of Proteome Research 8, no. 11:5387–5395. PNNL-SA-67312.

2008

• Ansong C., H. Yoon, A.D. Norbeck, J.K. Gustin, J.E. McDermott, H.M. Mottaz, and J. Rue, et al. 2008. "Proteomics Analysis of the Causative Agent of Typhoid Fever." Journal of Proteome Research 7, no. 2:546–557. PNNL-SA-56065. doi:10.1021/pr070434u
• Brewer H.M., A.D. Norbeck, J.N. Adkins, N.P. Manes, C. Ansong, L. Shi, and Y. Rikihisa, et al. 2008. "Optimization of proteomic sample preparation procedures for comprehensive protein characterization of pathogenic systems." Journal of Biomolecular Techniques:JBT 19, no. 5:285–295. PNNL-SA-60633.
• Huang H., M. Lin, X. Wang, T. Kikuchi, H.M. Mottaz, A.D. Norbeck, and Y. Rikihisa. 2008. "Proteomic Analysis of and Immune Responses to Ehrlichia chaffeensis Lipoproteins." Infection and Immunity 76, no. 8:3405–3414. PNNL-SA-60631. doi:10.1128/IAI.00056-08
• Romine M.F., T. Carlson, A.D. Norbeck, L.A. McCue, and M.S. Lipton. 2008. "Identification of Mobile Elements and Pseudogenes in the Shewanella oneidensis MR-1 Genome." Applied and Environmental Microbiology 74, no. 10:3257–3265. PNNL-SA-60499.
• Sowell S.M., A.D. Norbeck, M.S. Lipton, C.D. Nicora, S.J. Callister, R.D. Smith, and D.F. Barofsky, et al. 2008. "Proteomic Analysis of Stationary Phase in the Marine Bacterium 'Candidatus Pelagibacter ubique'." Applied and Environmental Microbiology 74, no. 13:4091–4100. PNNL-SA-114147. doi:10.1128/AEM.00599-08

2007

• Manes N.P., J.K. Gustin, J. Rue, H.M. Mottaz, S.O. Purvine, A.D. Norbeck, and M.E. Monroe, et al. 2007. "Targeted Protein Degradation by Salmonella under Phagosome-Mimicking Culture Conditions Investigated Using Comparative Peptidomics." Molecular & Cellular Proteomics. MCP 6, no. 4:717–727. PNNL-SA-50929. doi:10.1074/mcp.M600282-MCP200

2006

• Adkins J.N., H.M. Mottaz, A.D. Norbeck, J.K. Gustin, J. Rue, T.R. Clauss, and S.O. Purvine, et al. 2006. "Analysis of the Salmonella typhimurium Proteome through Environmental Response toward Infectious Conditions." Molecular & Cellular Proteomics. MCP 5, no. 8:1450–1461. PNNL-SA-46556. doi:10.1074/mcp.M600139-MCP200
• Liu T., W. Qian, H.M. Mottaz, M.A. Gritsenko, A.D. Norbeck, R.J. Moore, and S.O. Purvine, et al. 2006. "Evaluation of Multi-Protein Immunoaffinity Subtraction for Plasma Proteomics and Candidate Biomarker Discovery Using Mass Spectrometry." Molecular & Cellular Proteomics. MCP 5, no. 11:2167–2174. PNWD-SA-7363.
• Norbeck A.D., S.J. Callister, M.E. Monroe, N. Jaitly, D.A. Elias, M.S. Lipton, and R.D. Smith. 2006. "Proteomic approaches to bacterial differentiation." Journal of Microbiological Methods 67, no. 3:473–486. PNNL-SA-46770. doi:10.1016/j.mimet.2006.04.024
• Norbeck A.D., S.J. Callister, M.E. Monroe, N. Jaitly, D.A. Elias, M.S. Lipton, and R.D. Smith. 2006. "Proteomic approaches to bacterial differentiation." Journal of Microbiological Methods 67, no. 3:473–486. PNNL-SA-47555.
• Shi L., J.N. Adkins, J.R. Coleman, A.A. Schepmoes, A. Dohnalkova, H.M. Mottaz, and A.D. Norbeck, et al. 2006. "Proteomic Analysis of Salmonella enterica Serovar Typhimurium Isolated from RAW 264.7 Macrophages: identification of a novel protein that contributes to the replication of serovar Typhimurium inside macrophages." Journal of Biological Chemistry 281. PNNL-SA-51416. doi:10.1074/jbc.M604640200

2005

• Norbeck A.D., M.E. Monroe, J.N. Adkins, K.K. Anderson, D.S. Daly, and R.D. Smith. 2005. "The utility of accurate mass and LC elution time information in the analysis of complex proteomes." Journal of the American Society for Mass Spectrometry 16, no. 8:1239–1249. PNNL-SA-44395.