Biography

Dr. Amar Parvate is a chemist with the Structural Biology team in PNNL’s Environmental Molecular Sciences Division and the Environmental Molecular Sciences Laboratory (EMSL) user program. He specializes in cryo-electron microscopy (cryo-EM). His training includes biochemistry, cryo-EM, and tomography to perform structural analyses of viruses and antigen-antibody complexes. His current research involves using single-particle cryo-EM to solve structures of macromolecular assemblies of proteins of interest. 

 

Research Interest

  • Biochemistry 

  • Cryo-EM 

  • Protein engineering 

  • Protein structure 

  • Structural biology 

  • Virology 

Education

PhD in Biological Sciences, Purdue University, 2018

Awards and Recognitions

  • Bilsland Dissertation Fellowship, Purdue University (2018) 

  • Teaching Assistant Award, Department of Biological Sciences, Purdue University (2018) 

Publications

2020 

  • Parvate A., Sengupta R., Williams E. P., Xue Y, Chu YC, Stahlein R. V., and Jonsson C. B. 2020, “Cryofixation of Inactivated Hantavirus-Infected Cells as a Method for Obtaining High-Quality Ultrastructural Preservation for Electron Microscopic Studies.” Frontiers in Cellular and Infection Microbiology. doi.org/10.3389/fcimb.2020.580339.  

  • Parvate, A. D., F. Vago, S. S. Hasan, J. Lee, E. P. Williams, J. Lanman, and C. B. Jonsson. 2020. “A New Inactivation Method to Facilitate Cryo-EM of Enveloped, RNA Viruses Requiring High Containment: A Case Study Using Venezuelan Equine Encephalitis Virus (VEEV).” Journal of Virological Methods 277. doi.org/10.1016/j.jviromet.2019.113792. 

2019 

  • Parvate, A., E. P. Williams, M. K. Taylor, Y. K. Chu, J. Lanman, E. O. Saphire, and C. B. Jonsson. 2019. “Diverse Morphology and Structural Features of Old and New World Hantaviruses.” Viruses 11 (9). doi.org/10.3390/v11090862.