Directionally biased electrostatic interactions are the key to significantly tuning the reduction potential of iron/sulfur clusters.

Scientists map how transitions from day to night control gene regulatory networks in cyanobacteria, revealing key orchestrators of metabolic switching.

Scientists uncover how cyanobacteria's circadian cycle controls carbon and energy metabolism, increasing carbon dioxide-to-bioproducts yields.

Researchers at PNNL are pursuing new approaches to understand, predict and control the phenome—the collection of biological traits within an organism shaped by its genes and interactions with the environment.

Researchers developed a robust, cost-effective, and easy-to-use cap-based technique for spatial proteome mapping, addressing the lack of accessible proteomics technologies for studying tissue heterogeneity and microenvironments.

PNNL’s year in review includes highlights ranging from advancing soil science to understanding Earth systems, expanding electricity transmission, detecting fentanyl, and applying artificial intelligence to aid scientific discovery.

This project sought to assure that research activities centered around different sampling and monitoring efforts in northwest Ohio would not disturb any historical cultural resources.

A multi-institutional team of researchers systematically compared extraction techniques for characterizing plant litter composition that relies on organic matter extraction.

PNNL scientists use proteomics to unveil how high-density lipoproteins protect against cholesterol accumulation in the artery wall.

Computing and artificial intelligence aid scientists who seek to understand function-driven design and control of biological systems.

Controlling the nanostructure of silk fibroin—a protein found in silk—is a key step toward designing and fabricating electronics that leverage the material’s promising mechanical, optical and biocompatible properties.

This study evaluated the sensitivity of multiple geophysical methods to measure and evaluate the spatiotemporal variability of select soil properties across terrestrial–aquatic interfaces.

Researchers integrated field measurements, lab experiments, and model simulations to study oxygen consumption dynamics in soils along a coastal gradient.

This research explores how changes in groundwater levels affect the chemistry of underground water, especially in areas where land meets water, like wetlands.

A cross-institutional team of scientists developed PeakQC, a new software tool for automated quality control of mass spectrometry data.

This study examined the role of river sinuosity using computer models to understand what drives hyporheic exchange, a process that significantly affects water quality and ecosystem health.

PNNL biodefense experts seek to identify, understand and mitigate the risks of biological pathogens—whether naturally occurring or intentionally created—so steps can be taken to prepare and respond.

From enhancing biofuel crops to setting up automated experiments and improving energy storage—interns at PNNL are making an impact.