Researchers at PNNL are pursuing new approaches to understand, predict and control the phenome—the collection of biological traits within an organism shaped by its genes and interactions with the environment.

This week at AAAS, PNNL scientists discuss phenomics and the factors that influence DNA instructions to bring about the world around us.

Researchers developed a robust, cost-effective, and easy-to-use cap-based technique for spatial proteome mapping, addressing the lack of accessible proteomics technologies for studying tissue heterogeneity and microenvironments.

The Pacific Northwest Association of Toxicologists (PANWAT) presented its annual Toxicology Achievement Award to Katrina Waters at the Society of Toxicology Pacific Northwest Chapter Meeting, held in Lynnwood, Washington, on September 30th.

PNNL biodefense experts seek to identify, understand and mitigate the risks of biological pathogens—whether naturally occurring or intentionally created—so steps can be taken to prepare and respond.

Early life exposure to polycyclic aromatic hydrocarbons (PAHs), found in smoke, has been linked to developmental problems. To study the impacts of these pollutants, PAH metabolism in infants and adults were compared.

Ljiljana Paša-Tolić, a PNNL fellow, is the recipient of the 2024 International Mass Spectrometry Foundation’s Jochen Franzen Award. 

PMedIC, the PNNL and OHSU joint research collaboration, contributes to student success and impact in biomedicine.

PNNL contributes to a nationwide research consortium investigating the molecular mechanisms triggered by endurance training.

PNNL scientists took thousands of measurements of firefighters in training to learn more about how the body responds to vigorous exercise.

Scientists screen for nanobodies that recognize wild type and mutant functional proteins to develop a framework to disrupt protein interactions that can cause disease.

This study profiled the 24-hour rhythmicity in bile salt hydrolase enzyme activity using simple fluorescence assay and the results showed that this rhythmicity is influenced by feeding patterns of the host.

Lauren Charles, a chief data scientist at PNNL, joined the editorial board of the largest open access journal published by Nature Research.

Joshua Adkins and Jamie Lo will lead PMedIC, Pacific Northwest National Laboratory and Oregon Health & Science University’s joint research institute.

New research from PNNL and Washington State University collaborators connects the microbiome in the gut to circadian rhythms, suggesting a role for the microbiome as an internal regulator.

Advanced proteomic analysis tools dig deep into human blood plasma to understand the molecular nature of advanced alcoholic disease.

A paper by PNNL researchers has been chosen as one of 32 NIEHS Papers of the Year—a top 1% honor in the research field.

PNNL Biomedical Scientist Geremy Clair has taken on new roles as an editor for two journals; Frontiers In Cellular And Infection Microbiology and Frontiers In Molecular Biosciences.

Silicone wristbands could be more convenient option for collecting exposure data.

The virus that causes COVID-19 takes over the body’s fat-processing system and boosts cellular triglycerides as it causes disease.