The line broadening in biological samples can be suppressed using 1H-PASS method applied at a sample spinning rate of about 100 Hz or less. A novel slow MAS probe that is capable of high resolution and high sensitivity metabolic profiling on biological samples with volume as small as a few hundred nanoliters to sample volume as large as a few milliliter is developed. The nanoliter capability may make it possible to follow the metabolic changes through a continued investigation on a single small laboratory animal over a long period of time using minimally invasive blood and tissue biopsy samples. While the milliliter capability would allow minimal destructive studies of intact biological object with size as large as a few cm