The production of liquid fuel from coal via gasification and catalytic synthesis is one of the few feasible strategies for improving the nation’s energy security. Sulfur, even in extremely low concentrations, can poison the metallic catalysts used in coal-to-liquid process. This is a result of strong binding between sulfur and metal catalysts, such that the catalytically active sites are rendered inactive. From an alternate point of view, metallic-based sulfur sorbents may be considered a vehicle for deep desulfurization of warm coal gas. Here we report that Ni-doped cubic structure mesoporous silica can be used as a regenerable sorbent for deep desulfurization of warm coal gas at 300C. Regenerable sulfur capacity of this sorbent is ~0.75 wt%.