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Advanced Computing,
Mathematics, and Data

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Advancing the Science of Computing

The Advanced Computing, Mathematics, and Data (ACMD) Division focuses on basic and applied computing research encompassing data and computational engineering, data science, machine intelligence, high-performance computing, and applied mathematics to support R&D efforts spanning across all Pacific Northwest National Laboratory mission areas.

Our scientists and engineers design next-generation algorithms to analyze, model, and visualize complex systems; develop new artificial intelligence (AI) and machine learning (ML) methods and tools; apply co-design principles to optimize the performance and energy efficiency of future heterogeneous and reconfigurable computing systems; develop, deploy, and operate advanced software and data architectures; apply mathematical modeling and simulation to discover new chemicals and materials; and contribute to advance autonomic control for cyber-enabled infrastructures.

Featured Stories

a woman using a computer
OCTOBER 19, 2026
News Release

PermitAI Team Delivers a One-Stop-Shop for Federal Permitting Data

The PermitAI™ team at PNNL has issued two new upgrades to its public resources for searching federal environmental permitting data.
( Read More )
a map of the usa pointing to 9 national labs
OCTOBER 15, 2026
News Release

PNNL and Berkeley Lab Lead Genesis Mission Skills Release

New shared research computing infrastructure for Genesis Mission released today.
( Read More )
Genesis Mission awardees
OCTOBER 9, 2026
Feature

Genesis Mission Draws on PNNL Expertise for Five New SI-Driven Projects

New Genesis Mission projects aim to solve challenging problems in grid, computing, physics and geothermal energy with PNNL contributions.
( Read More )
A gloved man uses a tool to work on an electronic device.
OCTOBER 5, 2026
Feature

An AI Agent for Physics Could Speed Up Quantum Computing and Dark Matter Searches

An AI agent that can auto-tune an amplifier could speed up quantum computing development and dark matter discovery. Researchers at PNNL are working to find out with a Genesis Mission–funded project.
( Read More )
Illustration of a starburst like network and multicolored wave
AUGUST 20, 2026
Article

Improving the Prediction Ability of Spiking Neural Networks

Researchers showed that spiking neural networks can be accurate for regression problems, opening opportunities for efficient neuromorphic computing.
( Read More )
Four people posing for a group photo
AUGUST 5, 2026
News Release

Inside PNNL’s Lab-Wide Push for Trustworthy Autonomous Science

PNNL Launches Center for Robotics and Autonomy to advance trustworthy autonomous science at speed and scale.
( Read More )
Several people posing on a staircase.
JULY 22, 2026
News Release

Genesis Mission Awards to Accelerate AI Integration Across PNNL Science Mission

Genesis Mission awards to PNNL will advance scientific discovery, next-generation energy systems and advanced manufacturing, among others.
( Read More )
man staring at a computer monitor
JUNE 29, 2026
News Release

PermitAI Public-Private Partnership Speeds Environmental Review Drafting Tasks

Coding agents repurposed to draft complex environmental impact statement sections through PermitAI public-private partnership model.
( Read More )
Illustration of a high-performance computer connected to a series of individual quantum computers
JUNE 15, 2026
Feature

PNNL Prepares for Quantum Advantage

PNNL convenes leaders from the Department of Energy, national laboratories, computing industry and academia for a two-day workshop to advance quantum computing for computational chemistry.
( Read More )
Antonio Tumeo wears a striped shirt and glasses, with a computer screen in the background
JUNE 10, 2026
Staff Accomplishment

Tumeo Editing Special Issue on Democratizing Microelectronics

Computer scientist Antonino Tumeo is guest editing a special issue of IEEE’s Computer publication focused on democratizing microelectronics.
( Read More )
A man posing next to large computers
JUNE 1, 2026
Article

PNNL Researchers Achieve High-Level Quality of Service

A research team from Pacific Northwest National Laboratory used machine reasoning to schedule scientific workflows while guaranteeing quality of service (QoS).
( Read More )
Two PNNL scientists superimposed over a scene at the AI+ Expo in Washington, D.C.
MAY 28, 2026
Article

PNNL Researchers Showcase AI Leadership at AI+ Expo

PNNL researchers highlighted advances in AI for scientific discovery at the AI+ Expo, showcasing generative AI, autonomous research workflows, and scalable AI systems supporting energy, security, and national competitiveness.
( Read More )
A smiling man in a lab setting
MAY 27, 2026
News Release

AI Speeds Selective and High-Yield Recovery of Critical Minerals from Industrial Waste

Critical minerals could be sourced from industrial waste at scale thanks to an AI-guided separation workflow developed by researchers at PNNL.
( Read More )
2026 National Science Bowl Presenters Rallo (left) and Hodas (right)
APRIL 30, 2026
News Release

PNNL Researchers to Speak About Genesis Mission at National Science Bowl

PNNL’s Robert Rallo and Nathan Hodas speak to students about the future of AI.
( Read More )
A man signing a piece of equipment
APRIL 27, 2026
Feature

Decoding the Language of Plants and Microbes Using AI

Scientists are optimizing microbes to harvest critical minerals and produce bioproducts using AI and autonomous lab equipment.
( Read More )
an abstract representation of a quantum computing problem being solved
APRIL 23, 2026
News Release

AI Accelerators Deliver Accurate Models for Challenging Quantum Chemistry Calculations

An international research team deployed AI-powered computing to solve important chemical structures for energy applications using NVIDIA hardware.
( Read More )
The photo shows Joseph Aguayo on the left and Mahantesh Halappanavar on the right, in front of a large blue wall that reads “Cyber Security Operations,” with a clock with black background and red digits at the top of the wall.
MARCH 26, 2026
News Release

AI Effort Moves from Novelty to Front Lines of National Lab’s Cyber Protection

PNNL cyber defenders are using the Laboratory’s own artificial intelligence research to recognize and address threats quickly.
( Read More )
abstract image of computing hardware
MARCH 16, 2026
News Release

PNNL Brings Open-Source GPU Acceleration to Quantum with NVIDIA NVQLink

PNNL set to create a practical path for near-term hybrid classical-quantum computers with NVIDIA accelerated computing.
( Read More )
A researcher with a control device standing behind a robotic arm holding a lab sample tray.
MARCH 10, 2026
Feature

Autonomy Accelerates Science on a National Scale

Autonomous science laboratories are taking shape quickly across the PNNL campus.
( Read More )
Composite image of headshots of Neeraj Kumar and Kirsten Hofmockel
FEBRUARY 19, 2026
Staff Accomplishment

Integrating AI into Biological Research

Pacific Northwest National Laboratory scientists envision new research frontiers at the intersection of biology and AI
( Read More )
person holding a computer
FEBRUARY 17, 2026
News Release

PNNL Powers Biotechnology, Grid Operations, Nuclear Science Through Genesis AI for Science Mission

PNNL is central to the Genesis Mission, leading and participating in projects central to the nation’s security and international competitiveness.
( Read More )
The photo shows a red line made by a seismograph, squiggling up and down from left to right.
FEBRUARY 11, 2026
News Release

Earthquake Data Provide Solid Footing for AI Foundation Science Model

Scientists are tapping earthquake data to develop a new AI foundation model called SeisModal.
( Read More )
DOE Secretary Chris Wright wearing safety glasses
FEBRUARY 2, 2026
Article

Secretary Wright Celebrates Scientific Innovation at Pacific Northwest National Laboratory 

Secretary Wright visited PNNL's campus in Richland, Washington, late last year to meet with innovators in chemistry, biology, computing, and more.
( Read More )
Photo shows a man and a woman sitting on chairs on a stage, holding microphones and looking at an audience. In the background, a projected slide shows "PNNL Welcomes Dario Gil"
JANUARY 26, 2026
Article

DOE’s Under Secretary for Science Visits PNNL, Highlights Lab’s Role in AI-Driven Discovery

Darío Gil, DOE's Undersecretary for Science, makes his inaugural visit to PNNL.
( Read More )
Open Source Data Center Atlas screenshot
JANUARY 21, 2026
Article

Mapping the Future of Data Centers: A New Public Tool Illuminates What’s Next

Now, anyone can easily explore and access data from a nationwide map of data centers, the infrastructure that powers them, and projections of future data center locations.
( Read More )
Panos Stinis
DECEMBER 10, 2025
Article

PNNL Leads the Latest SciDAC Institute

The Scientific Discovery through Advanced Computing institute will focus on making scientific machine learning accessible to domain scientists.
( Read More )
Genesis Mission
NOVEMBER 24, 2025
News Release

Energy Department Launches ‘Genesis Mission’ to Transform American Science and Innovation Through the AI Computing Revolution

The Genesis Mission will mobilize the Department of Energy’s 17 National Laboratories, industry, and academia to build an integrated discovery platform.
( Read More )
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Computing

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