Optical, SEM and TEM analysis confirmed the presence of moderate sensitization in the 20% cold worked 316SS after the iron aluminide coating was applied. The Cr depletion occurs on the grain boundaries between the closely spaced carbides, and at the interface between the carbides and matrix. Cr depletion varied from locally along the grain boundaries, in many cases showing levels down to 15 wt%, but a few isolated regions had depletion levels down to 12.5 wt%. Optical and SEM images taken from a weld heat affected zone revealed the recrystallization occurred after an end plug cap had been welded to the coated cladding. Irradiation did not affect the carbides in a noticeable manner, but radiation-induced segregation/depletion altered the Cr depletion profiles by removing the wide Cr depletion profile, and replacing it with a much deeper, more narrow profile. Cr levels were depleted to 8-10 wt%, Ni and Si were enriched to levels of 40 wt% and 12 wt% respectively. Substantial precipitation formed in the matrix, and on line dislocations in the matrix and on grain boundary dislocations. Voids were observed in the upper region of the TPBAR where the irradiation temperature exceeds 320C. The levels of Cr depletion and Ni/Si enrichment indicate a material in a state susceptible to irradiation assisted stress corrosion cracking.