PNNL

Abstract

We introduce Eliater, a Python package for estimating the effect of perturbation of an upstream molecule on a downstream molecule in a biomolecular network. The estimation takes as input a biomolecular network, observational biomolecular data, and a perturbation of interest, and outputs an estimated quantitative effect of the perturbation. We showcase the functionalities of Eliater in a case study of E. coli transcriptional network. Availability and implementation: The code, the documentation, and several case studies are available open source at https://github.com/y0-causal-inference/eliater