In this paper, a thermogelling aqueous solution of biodegradable graft copolymer, poly(DL-lacid acid-co-glycolic acid) grafted with poly(ethylene glycol) (PLGA-g-PEG) is reported. The graft copolymer was synthesized by ring opening polymerization of DL-lactide, glycolide, and epoxy terminated poly(ethylene glycol) (PEG;m.w.=600) using stannous octoate as catalyst. DL-lactid acid/glycolic acid/ ethylene glkycol ratio is 3.2/1/2.8 by mole which was determined by H-NMR. Therefore, the grafting frequency of PEG is 4.7% by mole. The weight average molecular weight (Mw) and polydispersity (Mw/Mn) of the polymers determined by gel permeation chromatography (GPC) relative polystyrene standards using Tetrahydrofuran as an eluting solvent are 4200 and 1.34, respectively
Revised: October 22, 2001 |
Published: August 21, 2001
Citation
Jeong B., L.Q. Wang, and A. Gutowska. 2001.Biodegradable thermoreversible gelling PLGA-g-PEG copolymers.Chemical Communications. PNWD-SA-5073.