PNNL

Data scientist Isabelle O’Bryon came to Pacific Northwest National Laboratory (PNNL) in 2018 as a post-masters in the Chemical and Biological Signature Sciences Division. She started her work as a data scientist in 2020. O’Bryon works in the Chemometics and Bioinformatics group doing proteomics analysis of mass spectrometry data for forensic applications. She conducts peptidomics and proteomics analysis using data-dependent acquisition and data-independent acquisition methods. 

O’Bryon has also contributed to developing and maintaining the PNNL COVID-19 test laboratory information management system (LIMS). She is a recipient of the Department of Energy Secretary’s Honor Awards for her work on the COVID-19 Clinical Testing Team.

She received her BS and MS degrees in bioinformatics in 2018 from the Rochester Institute of Technology, where she studied grape skin microbiomes. 

• Proteomics
• Peptidomics
• Forensics
• Bioinformatics analysis
• Peptide spectral libraries

BS and MS in bioinformatics from the Rochester Institute of Technology

• Laboratory Director’s Pathway to Excellence Award, 2022
• Outstanding Performance Award, 2022
• Laboratory Director’s Award for Operational Excellence, 2021
• The Secretary’s Achievement Award, Department of Energy, 2021
• Outstanding Performance Award, 2021

O’Bryon, I.; Jenson, S. C.; Merkley, E. D. Flying Blind, or Just Flying under the Radar? The Underappreciated Power of de Novo Methods of Mass Spectrometric Peptide Identification. Protein Science. 2020, 29 (9), 1864–1878. https://doi.org/10.1002/pro.3919.

O’Bryon, I.; Tucker, A. E.; Kaiser, B. L. D.; Wahl, K. L.; Merkley, E. D. Constructing a Tandem Mass Spectral Library for Forensic Ricin Identification. J. Proteome Res. 2019, 18 (11), 3926–3935. https://doi.org/10.1021/acs.jproteome.9b00377.