PNNL

PNNL authors of Society of Toxicology Best Biological Modeling Paper in 2015. Enlarge image.

Congratulations to PNNL toxicologists who received honors from the Society of Toxicology (SOT) for a published paper and abstract at the society's annual meeting March 13-17.

"Comparative Risks of Aldehyde Constituents in Cigarette Smoke Using Transient Computational Fluid Dynamics/Physiologically Based Pharmacokinetic Models of the Rat and Human Respiratory Tracts," published in Toxicological Sciences, was named Best Biological Modeling Paper in 2015 by SOT's Biological Modeling Specialty Section. The paper describes advances in computational fluid dynamics modeling of respiratory tissue exposures to cigarette smoke. Lead author is Rick Corley, and the PNNL co-authors are Daniel Einstein, Senthil Kabilan, Andrew Kuprat, Richard Jacob, Kevin Minard, Justin Teeguarden, and Chuck Timchalk.

PNNL authors of Society of Toxicology Top 10 Risk Assessment Abstract. Enlarge image

Chuck Timchalk, Jordan Smith, Zana Carver, and Tom Weber's presentation abstract was named one of the Top 10 SOT Risk Assessment Abstracts in 2015 by the society's Risk Assessment Specialty Section (RASS). "Extrapolating Salivary Acinar Cell In Vitro Pesticide Transport to Whole Animals Using Computational Modeling" demonstrates a combined experimental and computational approach to predict chemical transport in saliva non-invasively. Such an approach has the potential to significantly advance quantitative dosimetry as an integral component of epidemiology.

The authors were recognized during the annual meeting in New Orleans, Louisiana. The RASS is the largest specialty section of the SOT, the major scientific society focusing on acquisition and use of knowledge in toxicology to help protect human health. It has more than 7,000 members worldwide.

Reference: Corley, RA, S Kabilan, AP Kuprat, JP Carson, RE Jacob, KR Minard, JG Teeguarden, C Timchalk, S Pipavath, RW Glenny, and DR Einstein. 2015. "Comparative Risks of Aldehyde Constituents in Cigarette Smoke Using Transient Computational Fluid Dynamics/Physiologically Based Pharmacokinetic Models of the Rat and Human Respiratory Tracts." Toxicological Sciences 146(1): 65-88. DOI: 10.1093/toxsci/kfv071.