Methyl iodide (MeI) is an intermediate in the manufacture of some pesticides and pharmaceuticals and it is under review for U.S. registration as a non-ozone depleting alternative for methyl bromide in the pre-plant soil fumigation market. MeI is metabolized via conjugation with glutathione (GSH) and further metabolism to S-methyl cysteine and methanethiol, or via a minor CYP450 oxidation to formaldehyde. A potential mode of action for any adverse effects due to MeI exposures may involve iodide release or GSH depletion. The GSH-dependent losses of MeI from the
Revised: July 22, 2010 |
Published: June 1, 2009
Citation
Poet T.S., H. Wu, R.A. Corley, and K.D. Thrall. 2009.In vitro glutathione conjugation of methyl iodide in rat, rabbit, and human blood and tissues.Inhalation Toxicology 21, no. 5-7:524-530. PNWD-SA-8628.