INTRODUCTION-Analytical methods based on ion transport in gases under the influence of electric field, known collectively as Ion Mobility Spectrometry (IMS), add major new capabilities to mass-spectrometric (MS) investigations. Separation of ion mixtures and characterization of ions by IMS are of particular utility in biological MS, where the sample complexity creates a virtually open-ended demand for separation power (1) while the ion size normally rules out structural elucidation by spectroscopic means. The use of IMS in mass spectrometry of proteins and peptides has expanded dramatically since the previous edition of this volume in 2000...
Revised: October 5, 2009 |
Published: September 1, 2008
Citation
Shvartsburg A.A., K. Tang, and R.D. Smith. 2008.Two-Dimensional Ion Mobility Analyses of Proteins and Peptides. In Mass Spectrometry of Proteins and Peptides: Methods and Protocols, Methods in Molecular Biology, edited by MS Lipton and L Pasa-Tolic. 417-445. Totowa, New Jersey:Humana Press.PNNL-SA-53042.