Tuberculosis-like lesions arising from the use of Freund's complete adjuvant in an owl monkey (Aotus sp)

April 1, 2004

Journal Article

Tuberculosis-like lesions arising from the use of Freund's complete adjuvant in an owl monkey (Aotus sp)

Abstract

An apparently normal, non-tuberculin-reacting, splenectomized owl monkey presented tuberculosis-like lesions of the lung at necropsy. Histological and bacteriological examination failed to demonstrate the presence of acid-fast organisms. Retrospective inquiry showed the animal had been inoculated using complete Freund's Adjuvant during a malaria vaccine trial. Lesions observed were compatible with lipid embolism of the adjuvant in the lungs.

Revised: February 18, 2005 | Published: April 1, 2004

Citation

Malaga C.A., R.E. Weller, J.R. Broderson, and A.S. Gozalo. 2004. Tuberculosis-like lesions arising from the use of Freund's complete adjuvant in an owl monkey (Aotus sp). Journal of Medical Primatology 33, no. 2:109-112. PNWD-SA-5293.