Distance-of-flight mass spectrometry (DOFMS) is a velocity-based mass-separation technique in which ions are separated in space along the plane of a spatially selective detector. In the present work, a solid-state charge-detection array, the focal-plane camera (FPC), was incorporated into the DOFMS platform. Use of the FPC with our DOFMS instrument resulted in improvements in analytical performance, usability, and versatility over a previous generation instrument that employed a microchannel-plate/phosphor DOF detector. Notably, FPC detection provided resolution improvements of at least a factor of 2, with typical DOF linewidths of 300 µm (R((fwhm)) = 1000). The merits of solid-state detection for DOFMS are evaluated, and methods to extend the DOFMS mass range are considered.
Revised: March 20, 2014 |
Published: November 15, 2011
Citation
Graham A.W., S.J. Ray, C.G. Enke, J.A. Felton, A.J. Carado, C.J. Barinaga, and D.W. Koppenaal, et al. 2011.Resolution and Mass Range Performance in Distance-of-flight Mass Spectrometry with a Multichannel Focal-Plane Camera Detector.Analytical Chemistry 83, no. 22:8552-8559.PNNL-SA-84240.doi:10.1021/ac201876y